| 1. |
- Kess, Daniel, et al.
(författare)
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Identification of susceptibility loci for skin disease in a murine psoriasis model
- 2006
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Ingår i: Journal of Immunology. - 1550-6606. ; 177:7, s. 4612-4619
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Tidskriftsartikel (refereegranskat)abstract
- Psoriasis is a frequently occurring inflammatory skin disease characterized by thickened erythematous skin that is covered with silvery scales. It is a complex genetic disease with both heritable and environmental factors contributing to onset and severity. The CD18 hypomorphic PL/J mouse reveals reduced expression of the common chain of beta(2) integrins (CD11/CD18) and spontaneously develops a skin disease that closely resembles human psoriasis. In contrast, CD18 hypomorphic C57BL/6J mice do not demonstrate this phenotype. In this study, we have performed a genome-wide scan to identify loci involved in psoriasiform dermatitis under the condition of low CD18 expression. Backcross analysis of a segregating cross between susceptible CD18 hypomorphic PL/J mice and the resistant CD18 hypomorphic C57BL/6J strain was performed. A genome-wide linkage analysis of 94 phenotypically extreme mice of the backcross was undertaken. Thereafter, a complementary analysis of the regions of interest from the genome-wide screen was done using higher marker density and further mice. We found two loci on chromosome 10 that were significantly linked to the disease and interacted in an additive fashion in its development. In addition, a locus on chromosome 6 that promoted earlier onset of the disease was identified in the most severely affected mice. For the first time, we have identified genetic regions associated with psoriasis in a mouse model resembling human psoriasis. The identification of gene regions associated with psoriasis in this mouse model might contribute to the understanding of genetic causes of psoriasis in patients and pathological mechanisms involved in development of disease.
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| 2. |
- Ny, Henrik, et al.
(författare)
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Introducing strategic decision support systems for sustainable product-service development across value chains
- 2008
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Konferensbidrag (refereegranskat)abstract
- Most companies do not have a coherent and systematic approach for incorporating sustainability criteria into their decision support systems. Given this, what would such a strategic decision support system (SDSS) look like that that is coherent throughout a development process and systematically incorporates (1) a full sustainability perspective, including (2) a broader approach to meeting needs by product-service systems, and (3) interfaces toward both specific groups of decision makers and specialized in-depth tools? We anticipate such an SDSS being structured by a framework for strategic sustainable development that provides a principle-based definition of sustainability and a systematic method to identify problems and solutions by backcasting from that definition. This should aid identification of potential benefits and challenges of shifting from a product-only focus to a focus on product-service systems. Additionally, the new sustainability and product-service system decision support should be flexible enough to be incorporated into existing decision-making processes. It will likely be formed around a built-in product development process at the companies.
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