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- Olsén, Lena, et al.
(författare)
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Cetirizine in horses : Pharmacokinetics and pharmacodynamics following repeated oral administration
- 2008
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Ingår i: The Veterinary Journal. - : Elsevier BV. - 1090-0233 .- 1532-2971. ; 177:2, s. 242-249
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Tidskriftsartikel (refereegranskat)abstract
- The pharmacokinetics of the histamine HI-antagonist cetirizine and its effect on histamine-induced cutaneous wheal formation were studied in six healthy horses following repeated oral administration. After three consecutive administrations of cetirizine (0.2 mg/kg body weight, bw) every 12 h, the trough plasma concentration of cetirizine was 16 +/- 4 ng/mL (mean +/- SD) and the wheal formation was inhibited by 45 +/- 23%. After four additional administrations of cetirizine (0.4 mg/kg bw) every 12 h, the trough plasma concentration was 48 +/- 15 ng/mL and the wheal formation was inhibited by 68 +/- 11%. The terminal half-life was about 5.8 h. A pharmacokinetic/ pharmacodynamic link model showed that the maximal inhibition of wheal formation was about 95% and the EC50 about 18 ng/mL. It is concluded that cetirizine in doses of 0.2-0.4 mg/kg bw administered at 12 h intervals exhibits favourable pharmacokinetic and pharmacodynamic properties without causing visible side effects, and the drug may therefore be a useful antihistamine in equine medicine.
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| 2. |
- Olsén, Lena, et al.
(författare)
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Pharmacokinetics and effects of cetirizine in horses with insect bite hypersensitivity
- 2011
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Ingår i: The Veterinary Journal. - : Elsevier BV. - 1090-0233 .- 1532-2971. ; 187:3, s. 347-351
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Tidskriftsartikel (refereegranskat)abstract
- Horses with insect bite hypersensitivity (IBH) have difficulty in completely avoiding allergens, so effective treatment options are required. A randomised, placebo controlled and double blinded field study was conducted to determine the pharmacokinetics and efficacy in reducing dermatitis of the antihistamine cetirizine given orally at 0.4mg/kg twice daily for 3weeks. The influence of protection blankets and stabling were also investigated. The estimated maximum plasma concentration (C(max)) and trough plasma concentration of cetirizine were 135ng/mL and 18ng/mL, respectively. There was no difference in dermatitis reduction between the treatment and placebo groups (P=0.77). The findings indicated that cetirizine was of no apparent benefit in treating IBH at the dose rate tested. The use of blankets and stabling were shown to have favourable influence on the dermatitis (P<0.05) and may be the preferred options to prevent this condition.
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| 8. |
- Broström, Anders, 1978-, et al.
(författare)
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How does University Collaboration Contribute to Successful R&D Management?
- 2008
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Ingår i: IUP Journal of Managerial Economics. - : IUP Publications. - 0972-9305. ; 6:4, s. 7-24
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- The issue—how a firm’s R&D (Research and Development) interaction with universities affects its innovation performance—remains under-researched. This study explores the relationship between firms’ collaboration with universities and their capabilities for innovation, as perceived by R&D managers. Drawing on a series of interviews with R&D managers of 45 randomly selected firms collaborating with two research universities in Sweden, we explicitly recognize mechanisms through which university relationships contribute to successful R&D management.
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| 9. |
- Broström, Anders, et al.
(författare)
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How Does University Collaboration Contribute to Successful R&D Management? : An examination of the Swedish setting
- 2008
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- The issue of through what processes R&D collaboration with universities affects a firms’innovation performance remains under-researched. In particular, university relationships have notbeen fully integrated in the open innovation framework. This study explores the relationshipbetween firms’ collaboration with universities and their capabilities for innovation, as perceivedby R&D managers. Drawing on a series of interviews with R&D managers at 45 randomlyselected firms collaborating with two research universities in Sweden, we explicitly recognisemechanisms through which university relationships contribute to successful R&D management.
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| 10. |
- Broström, Anders, 1978-
(författare)
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Strategists and Academics :
- 2009
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- This doctoral thesis consists of five self-contained essays on interaction in R&D between university researchers and private firms. Together, these essays explore the conditions under which private firms benefit from spillovers from publicly funded and organised research. From the first essay, which sets out to empirically validate the theoretical arguments about the benefits of university-industry interaction for private firms, the thesis follows a line of pursuit that goes back and forth between exploration of the different benefits that firms enjoy from university interaction and the relationships between these benefits and the conditions of interaction. In essay II, a typology of rationales for establishing cooperative relations is presented. A considerable breadth of interaction rationales is documented, but on closer examination, a “core” set of rationales related to innovation in terms of invented or improved products or processes are found to be the main drivers of interaction. Developing this view, three critical issues previously studied within innovation economics are re-considered from the point of view of firm rationales for interaction; public co-funding of university-firm interaction (essay II), the role of geographic proximity for interaction on R&D (essay III) and the organisation of public sector research (public research institutes and universities) in relation to firm level competences (essay IV). In a fifth essay, four ideal types of strategy for localised interaction between R&D subsidiaries and universities are proposed. Through the framework developed in this essay, the rationales for interaction are related to the overall R&D strategy of multinational firms. Concluding the thesis, it is discussed how the research presented herein opens up for improved theorizing around the roles of academic research for industrial innovation.
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