SwePub
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(Brown Anthony) "

Sökning: WFRF:(Brown Anthony)

  • Resultat 1-10 av 261
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
1.
  • Craddock, Nick, et al. (författare)
  • Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls
  • 2010
  • Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 464:7289, s. 713-720
  • Tidskriftsartikel (refereegranskat)abstract
    • Copy number variants (CNVs) account for a major proportion of human genetic polymorphism and have been predicted to have an important role in genetic susceptibility to common disease. To address this we undertook a large, direct genome-wide study of association between CNVs and eight common human diseases. Using a purpose-designed array we typed,19,000 individuals into distinct copy-number classes at 3,432 polymorphic CNVs, including an estimated similar to 50% of all common CNVs larger than 500 base pairs. We identified several biological artefacts that lead to false-positive associations, including systematic CNV differences between DNAs derived from blood and cell lines. Association testing and follow-up replication analyses confirmed three loci where CNVs were associated with disease-IRGM for Crohn's disease, HLA for Crohn's disease, rheumatoid arthritis and type 1 diabetes, and TSPAN8 for type 2 diabetes-although in each case the locus had previously been identified in single nucleotide polymorphism (SNP)-based studies, reflecting our observation that most common CNVs that are well-typed on our array are well tagged by SNPs and so have been indirectly explored through SNP studies. We conclude that common CNVs that can be typed on existing platforms are unlikely to contribute greatly to the genetic basis of common human diseases.
  •  
2.
  • Kattge, Jens, et al. (författare)
  • TRY plant trait database - enhanced coverage and open access
  • 2020
  • Ingår i: Global Change Biology. - : Wiley-Blackwell. - 1354-1013 .- 1365-2486. ; 26:1, s. 119-188
  • Tidskriftsartikel (refereegranskat)abstract
    • Plant traits-the morphological, anatomical, physiological, biochemical and phenological characteristics of plants-determine how plants respond to environmental factors, affect other trophic levels, and influence ecosystem properties and their benefits and detriments to people. Plant trait data thus represent the basis for a vast area of research spanning from evolutionary biology, community and functional ecology, to biodiversity conservation, ecosystem and landscape management, restoration, biogeography and earth system modelling. Since its foundation in 2007, the TRY database of plant traits has grown continuously. It now provides unprecedented data coverage under an open access data policy and is the main plant trait database used by the research community worldwide. Increasingly, the TRY database also supports new frontiers of trait-based plant research, including the identification of data gaps and the subsequent mobilization or measurement of new data. To support this development, in this article we evaluate the extent of the trait data compiled in TRY and analyse emerging patterns of data coverage and representativeness. Best species coverage is achieved for categorical traits-almost complete coverage for 'plant growth form'. However, most traits relevant for ecology and vegetation modelling are characterized by continuous intraspecific variation and trait-environmental relationships. These traits have to be measured on individual plants in their respective environment. Despite unprecedented data coverage, we observe a humbling lack of completeness and representativeness of these continuous traits in many aspects. We, therefore, conclude that reducing data gaps and biases in the TRY database remains a key challenge and requires a coordinated approach to data mobilization and trait measurements. This can only be achieved in collaboration with other initiatives.
  •  
3.
  •  
4.
  •  
5.
  •  
6.
  •  
7.
  •  
8.
  •  
9.
  •  
10.
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 1-10 av 261
Typ av publikation
tidskriftsartikel (254)
forskningsöversikt (4)
annan publikation (2)
konferensbidrag (1)
Typ av innehåll
refereegranskat (251)
övrigt vetenskapligt/konstnärligt (10)
Författare/redaktör
Aad, G (164)
Abbott, B. (164)
Abdinov, O (164)
Zwalinski, L. (164)
Gregersen, K. (164)
Poettgen, R. (164)
visa fler...
Aben, R. (164)
Abreu, H. (164)
Adye, T. (164)
Aielli, G. (164)
Albrand, S. (164)
Aleksa, M. (164)
Aleksandrov, I. N. (164)
Alexander, G. (164)
Alexopoulos, T. (164)
Alhroob, M. (164)
Aloisio, A. (164)
Alonso, A. (164)
Alonso, F. (164)
Altheimer, A. (164)
Alviggi, M. G. (164)
Amako, K. (164)
Amelung, C. (164)
Amoroso, S. (164)
Amram, N. (164)
Anastopoulos, C. (164)
Ancu, L. S. (164)
Andari, N. (164)
Andeen, T. (164)
Anders, G. (164)
Anderson, K. J. (164)
Andreazza, A. (164)
Angerami, A. (164)
Anghinolfi, F. (164)
Annovi, A. (164)
Antonelli, M. (164)
Antonov, A. (164)
Aoki, M. (164)
Arabidze, G. (164)
Arai, Y. (164)
Argyropoulos, S. (164)
Arnaez, O. (164)
Arnal, V. (164)
Artamonov, A. (164)
Artoni, G. (164)
Asai, S. (164)
Asbah, N. (164)
Asquith, L. (164)
Assamagan, K. (164)
Astalos, R. (164)
visa färre...
Lärosäte
Lunds universitet (187)
Stockholms universitet (184)
Uppsala universitet (175)
Kungliga Tekniska Högskolan (148)
Karolinska Institutet (21)
Göteborgs universitet (12)
visa fler...
Umeå universitet (9)
Linköpings universitet (5)
Sveriges Lantbruksuniversitet (4)
Mittuniversitetet (3)
Chalmers tekniska högskola (3)
Högskolan Dalarna (2)
Högskolan Kristianstad (1)
Högskolan i Gävle (1)
Handelshögskolan i Stockholm (1)
Karlstads universitet (1)
Naturhistoriska riksmuseet (1)
visa färre...
Språk
Engelska (261)
Forskningsämne (UKÄ/SCB)
Naturvetenskap (219)
Medicin och hälsovetenskap (30)
Humaniora (5)
Samhällsvetenskap (4)
Teknik (1)
Lantbruksvetenskap (1)

År

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy