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Sökning: WFRF:(Bruendermann Erik)

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1.
  • Ballout, Fouad, et al. (författare)
  • Scanning near-field IR microscopy of proteins in lipid bilayers
  • 2011
  • Ingår i: Physical Chemistry, Chemical Physics - PCCP. - : Royal Society of Chemistry (RSC). - 1463-9076 .- 1463-9084. ; 13:48, s. 21432-21436
  • Tidskriftsartikel (refereegranskat)abstract
    • We use infrared near-field microscopy to chemically map the morphology of biological matrices. The investigated sample is built up from surface-tethered membrane proteins (cytochrome c oxidase) reconstituted in a lipid bilayer. We have carried out infrared near-field measurements in the frequency range between 1600 and 1800 cm(-1). By simultaneously recording the topography and chemical fingerprint of the protein-tethered lipid bilayer with a lateral resolution of 80 nm x 80 nm, we were able to probe locally the chemical signature of this membrane and to provide a local map of its surface morphology.
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2.
  • Mischo, Meike, et al. (författare)
  • Similar appearance, different mechanisms : xerosis in HIV, atopic dermatitis and ageing
  • 2014
  • Ingår i: Experimental dermatology. - : Wiley. - 0906-6705 .- 1600-0625. ; 23:6, s. 446-448
  • Tidskriftsartikel (refereegranskat)abstract
    • Xerosis is one of the most common dermatologic disorders occurring in the elderly and in patients with atopic dermatitis (AD) and human immunodeficiency virus (HIV) infection. Xerosis has been linked to an impaired skin barrier function of the stratum corneum. Using Raman microspectroscopy, we concentrated on deeper skin layers, viable epidermis and dermis of 47 volunteers and associated molecular alterations to the evolution of xerosis and the skin barrier, for example, lipid, water and antioxidant content. A decrease in lipids within the viable epidermis is found for elderly and HIV-patients. Lipid and water values of AD patients and their healthy reference group are similar. Decreases in lipids and simultaneous increases in water are found in the dermis for HIV and AD patients in comparison to their healthy reference groups. Excessive levels of epidermal carotenoids, mainly lycopene, in HIV-patients were found potentially leading to adverse effects such as premature skin ageing.
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