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| 2. |
- Gu, Fangyi, et al.
(författare)
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Eighteen insulin-like growth factor pathway genes, circulating levels of IGF-I and its binding protein, and risk of prostate and breast cancer
- 2010
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Ingår i: Cancer Epidemiology, Biomarkers and Prevention. - : American Association for Cancer Research. - 1055-9965 .- 1538-7755. ; 19:11, s. 2877-2887
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Tidskriftsartikel (refereegranskat)abstract
- Background: Circulating levels of insulin-like growth factor I (IGF-I) and its main binding protein, IGF binding protein 3 (IGFBP-3), have been associated with risk of several types of cancer. Heritable factors explain up to 60% of the variation in IGF-I and IGFBP-3 in studies of adult twins.Methods: We systematically examined common genetic variation in 18 genes in the IGF signaling pathway for associations with circulating levels of IGF-I and IGFBP-3. A total of 302 single nucleotide polymorphisms (SNP) were genotyped in >5,500 Caucasian men and 5,500 Caucasian women from the Breast and Prostate Cancer Cohort Consortium.Results: After adjusting for multiple testing, SNPs in the IGF1 and SSTR5 genes were significantly associated with circulating IGF-I (P < 2.1 × 10−4); SNPs in the IGFBP3 and IGFALS genes were significantly associated with circulating IGFBP-3. Multi-SNP models explained R2 = 0.62% of the variation in circulating IGF-I and 3.9% of the variation in circulating IGFBP-3. We saw no significant association between these multi-SNP predictors of circulating IGF-I or IGFBP-3 and risk of prostate or breast cancers.Conclusion: Common genetic variation in the IGF1 and SSTR5 genes seems to influence circulating IGF-I levels, and variation in IGFBP3 and IGFALS seems to influence circulating IGFBP-3. However, these variants explain only a small percentage of the variation in circulating IGF-I and IGFBP-3 in Caucasian men and women.Impact: Further studies are needed to explore contributions from other genetic factors such as rare variants in these genes and variation outside of these genes.
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| 3. |
- Birch, J., et al.
(författare)
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Multi-Grid boron-10 detector for time-of-flight spectrometers in neutron scattering science
- 2015
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Ingår i: 2015 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2015. - : Institute of Electrical and Electronics Engineers (IEEE). - 9781467398626
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Konferensbidrag (refereegranskat)abstract
- The Multi-Grid (MG) detector has been introduced at ILL and developed by a collaboration between ILL, ESS and Linkoping University. This detector design addresses the severely decreased availability of He3, in particular for neutron scattering instruments with large-area detectors, such as time-of-flight neutron spectrometers at ESS and other facilities. The MG detector is based on thin converter films of boron-10 carbide arranged in layers orthogonal to the incoming neutrons. The design of the detector provides position resolution, efficiency competitive with He3 and a strong gamma rejection capability. This paper presents the MG large-area (2.4m2) demonstrator and the progress made in order to meet the needs of production of B4C-coated layers, mechanical parts and assembly on a scale similar to that of the final detectors for ESS. A particular effort was made to produce aluminium detector parts with a low alpha background, successfully reducing the background rate to acceptable levels. Following the IN5 demonstrator, a compact prototype has been designed in order to finalise the electronic readout to be used at the ESS instruments equipped with the MG.
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| 4. |
- Birch, Jens, et al.
(författare)
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In-beam test of the Boron-10 Multi-Grid neutron detector at the IN6 time-of-flight spectrometer at the ILL
- 2014
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Ingår i: INTERNATIONAL WORKSHOP ON NEUTRON OPTICS AND DETECTORS (NOPandD 2013). - : IOP Publishing: Conference Series / Institute of Physics (IoP).
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Konferensbidrag (refereegranskat)abstract
- A neutron detector concept based on solid layers of boron carbide enriched in 1 B has been in development for the last few years as an alternative for He-3 by collaboration between the ILL, ESS and Linkoping University. This Multi-Grid detector uses layers of aluminum substrates coated with (B4C)-B-10 on both sides that are traversed by the incoming neutrons. Detection is achieved using a gas counter readout principle. By segmenting the substrate and using multiple anode wires, the detector is made inherently position sensitive. This development is aimed primarily at neutron scattering instruments with large detector areas, such as time-of-flight chopper spectrometers. The most recent prototype has been built to be interchangeable with the He-3 detectors of IN6 at ILL. The 1 B detector has an active area of 32 x 48 cm(2). It was installed at the IN6 instrument and operated for several weeks, collecting data in parallel with the regularly scheduled experiments, thus providing the first side-by-side comparison with the conventional He-3 detectors. Results include an efficiency comparison, assessment of the in-detector scattering contribution, sensitivity to gamma-rays and the signal-to-noise ratio in time-of-flight spectra. The good expected performance has been confirmed with the exception of an unexpected background count rate. This has been identified as natural alpha activity in aluminum. New convertor substrates are under study to eliminate this source of background.
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| 5. |
- Obón-Santacana, M., et al.
(författare)
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Dietary intake of acrylamide and endometrial cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort
- 2014
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Ingår i: British Journal of Cancer. - : Nature Publishing Group. - 0007-0920 .- 1532-1827. ; 111:5, s. 987-997
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Three prospective studies have evaluated the association between dietary acrylamide intake and endometrial cancer (EC) risk with inconsistent results. The objective of this study was to evaluate the association between acrylamide intake and EC risk: for overall EC, for type-I EC, and in never smokers and never users of oral contraceptives (OCs). Smoking is a source of acrylamide, and OC use is a protective factor for EC risk. METHODS: Cox regression was used to estimate hazard ratios (HRs) for the association between acrylamide intake and EC risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Acrylamide intake was estimated from the EU acrylamide monitoring database, which was matched with EPIC questionnaire-based food consumption data. Acrylamide intake was energy adjusted using the residual method. RESULTS: No associations were observed between acrylamide intake and overall EC (n = 1382) or type-I EC risk (n = 627). We observed increasing relative risks for type-I EC with increasing acrylamide intake among women who both never smoked and were non-users of OCs (HRQ5vsQ1: 1.97, 95% CI: 1.08-3.62; likelihood ratio test (LRT) P-value: 0.01, n = 203). CONCLUSIONS: Dietary intake of acrylamide was not associated with overall or type-I EC risk; however, positive associations with type I were observed in women who were both non-users of OCs and never smokers.
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| 6. |
- Khaplanov, Anton, et al.
(författare)
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Investigation of gamma-ray sensitivity of neutron detectors based on thin converter films
- 2013
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Ingår i: Journal of Instrumentation. - 1748-0221. ; 8
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Tidskriftsartikel (refereegranskat)abstract
- Currently, many detector technologies for thermal neutron detection are in development in order to lower the demand for the rare He-3 gas. Gas detectors with solid thin film neutron converters readout by gas proportional counter method have been proposed as an appropriate choice for applications where large area coverage is necessary. In this paper, we investigate the probability for gamma-rays to generate a false count in a neutron measurement. Simulated results are compared to measurement with B-10 thin film prototypes and a He-3 detector. It is demonstrated that equal gamma-ray rejection to that of He-3 tubes is achieved with the new technology. The arguments and results presented here are also applicable to gas detectors with converters other than solid B-10 layers, such as Li-6 layers and (BF3)-B-10 gas.
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| 7. |
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| 8. |
- Piscitelli, F., et al.
(författare)
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Study of a high spatial resolution B-10-based thermal neutron detector for application in neutron reflectometry: the Multi-Blade prototype
- 2014
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Ingår i: Journal of Instrumentation. - 1748-0221. ; 9
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Tidskriftsartikel (refereegranskat)abstract
- Although for large area detectors it is crucial to find an alternative to detect thermal neutrons because of the He-3 shortage, this is not the case for small area detectors. Neutron scattering science is still growing its instruments' power and the neutron flux a detector must tolerate is increasing. For small area detectors the main effort is to expand the detectors' performances. At Institut Laue-Langevin (ILL) we developed the Multi-Blade detector which wants to increase the spatial resolution of He-3-based detectors for high flux applications. We developed a high spatial resolution prototype suitable for neutron reflectometry instruments. It exploits solid B-10-films employed in a proportional gas chamber. Two prototypes have been constructed at ILL and the results obtained on our monochromatic test beam line are presented here.
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| 9. |
- Birch, Jens, et al.
(författare)
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(B4C)-B-10 Multi-Grid as an Alternative to He-3 for Large Area Neutron Detectors
- 2013
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Ingår i: IEEE Transactions on Nuclear Science. - 0018-9499 .- 1558-1578. ; 60:2, s. 871-878
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Tidskriftsartikel (refereegranskat)abstract
- Despite its present shortage, He-3 continues to be the most common neutron converter for detectors in neutron scattering science. However, it is obvious that the development of large area neutron detectors based on alternative neutron converters is rapidly becoming a matter of urgency. In the technique presented here, grids each comprising 28 (B4C)-B-10 layers ( each 1 mu m thick) are used to convert neutrons into ionizing particles which are subsequently detected in proportional gas counters. The total active area of the prototype is 8 cm x 200 cm. To instrument this detector 4.6 m(2) of B-10-enriched boron carbide were coated onto aluminium blades using a DC magnetron sputtering machine. Characterization of the prototype showed neutron efficiency to be epsilon(n) = 46.8% for 2.5 angstrom neutrons, which is in line with expectations from MC simulation. This result demonstrates the potential of this technique as alternative to He-3-based position sensitive detectors.
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| 10. |
- Bartolini Bussi, M G, et al.
(författare)
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Mathematics in context: focusing on students
- 2009
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Ingår i: Challenging Mathematics In and Beyond the Classroom – The 16th ICMI Study. - New York : Springer Science+Business Media B.V.. - 9780387096032 ; , s. 171-203
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Bokkapitel (refereegranskat)abstract
- This chapter presents nine case studies in which school students engage in challenging mathematics outside their immediate classroom environment. In each case, students are encouraged to collaborate in investigations that go beyond the standard curriculum and creatively use the ingredients of the particular context. In Italy, students visit a mathematical laboratory to understand and utilize mathematical machines. Morning assembly at an Indian school brings students from many classes together in the solution of mathematical problems. Four of the projects are from France: students analyze the configuration of a heap of sand, pursue astronomical investigations with software, obtain a flavor of research by having secondary school teams investigate interesting problems, and are presented at all levels with open-ended research problems. There are three programs from the United States, the first, an advanced geometry sequence for secondary students completing the regular syllabus early, the second, activities arising from exhibits in an art museum, and the third, using the school lawn to deepen student understanding of geometric constructions. All such activities need to be evaluated for their effectiveness, so that they move from just being initiatives of dynamic individuals to serve as the foundation for systemic improvements in the way in which students learn, understand and use mathematics. In the early part of this chapter, we briefly mention how research into such activities might be approached.
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