| 1. |
- Bačkalov, I., et al.
(författare)
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Improvement of ship stability and safety in intact condition through operational measures : Challenges and opportunities
- 2016
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Ingår i: Ocean Engineering. - : Elsevier. - 0029-8018 .- 1873-5258. ; 120, s. 353-361
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Tidskriftsartikel (refereegranskat)abstract
- Attaining a sufficient level of safety from the point of view of stability is typically considered to be a matter of design. However, it is impossible to ensure safety only by design measures, and operational measures can then represent a complementary tool for efficiently and cost-effectively increasing the overall safety of the vessel. Time could therefore be coming for systematically considering operational measures as a recognised and regulated integral part of a holistic approach to ship safety from the point of view of stability. This paper therefore aims at capturing recent trends of research targeting operational safety measures, with specific attention to the intact ship condition. Open challenges and opportunities for research are identified, potential benefits and shortcomings of different options are discussed, and needs and possibilities for further developments in this area are explored. As an overall goal, this paper aims at providing food for thoughts as well as a ground for further proceeding towards the target of implementing a virtuous integrated approach to intact ship safety, from the point of view of stability, which gives due credit to effective and robust operational risk control options.
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| 2. |
- Bačkalov, I., et al.
(författare)
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Ship stability, dynamics and safety : Status and perspectives from a review of recent STAB conferences and ISSW events
- 2016
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Ingår i: Ocean Engineering. - : Elsevier. - 0029-8018 .- 1873-5258. ; 116, s. 312-349
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Forskningsöversikt (refereegranskat)abstract
- In Naval Architecture, the concept of "stability" has a very wide meaning, embracing ship stability fundamentals with ship dynamics and ultimately ship safety. As such, the subject is of paramount importance for its wide implications on design and operation of ships and floating units. Research in this field has, therefore, an important impact on the fleet safety, and the International Conferences on Stability of Ships and Ocean Vehicles (STAB Conferences) and the International Ship Stability Workshops (ISSW) are certainly the venues where expertise and contemporary developments in this specific field tend to be collected and thoroughly debated. With the aim of analysing the current status and possible future perspectives of research in the field of ship stability, dynamics and safety, this paper provides an extensive review of the findings presented at STAB Conferences and ISSW events in the period 2009-2014. The reviewed material is organised according to a set of identified macro-topics of research. On the basis of the reviewed material, consolidated research topics as well as emerging subjects are laid out, and ideas for possible future research are also brought forward. Discussion is also provided regarding the link between research and educational aspects.
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| 3. |
- Bomben, Riccardo, et al.
(författare)
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Comprehensive characterization of IGHV3-21-expressing B-cell chronic lymphocytic leukemia : an Italian multicenter study
- 2007
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Ingår i: Blood. - : American Society of Hematology. - 0006-4971 .- 1528-0020. ; 109:7, s. 2989-2998
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Tidskriftsartikel (refereegranskat)abstract
- IGHV3-21-using chronic lymphocytic leukemia (CLL) is a distinct entity with restricted immunoglobulin gene features and poor prognosis and is more frequently encountered in Northern than Southern Europe. To further investigate this subset and its geographic distribution in the context of a country (Italy) with both continental and Mediterranean areas, 37 IGHV3-21 CLLs were collected out of 1076 cases enrolled by different institutions from Northern or Central Southern Italy. Of the 37 cases, 18 were identified as homologous (hom)HCDR3-IGHV3-21 CLLs and were found almost exclusively (16 of 18) in Northern Italy; in contrast, 19 nonhomHCDR3-IGHV3-21 cases were evenly distributed throughout Italy. Clinically, poor survivals were documented for IGHV3-21 CLLs as well as for subgroups of mutated and homHCDR3-IGHV3-21 CLLs. Negative prognosticators CD38, ZAP-70, CD49d, and CD79b were expressed at higher levels in homHCDR3 than nonhomHCDR3-IGHV3-21 cases. Differential gene expression profiling (GEP) of 13 IGHV3-21 versus 52 non-IGHV3-21 CLLs identified, among 122 best-correlated genes, TGFB2 and VIPR1 as down- and up-regulated in IGHV3-21 CLL cases, respectively. Moreover, GEP of 7 homHCDR3 versus 6 nonhomHCDR3-IGHV3-21 CLLs yielded 20 differentially expressed genes, with WNT-16 being that expressed at the highest levels in homHCDR3-IGHV3-21 CLLs. Altogether, IGHV3-21 CLLs, including those with homHCDR3, had a peculiar global phenotype in part explaining their worse clinical outcome.
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| 4. |
- Willms, A. G., et al.
(författare)
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Factors influencing the fascial closure rate after open abdomen treatment : Results from the European Hernia Society (EuraHS) Registry Surgical technique matters
- 2022
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Ingår i: Hernia. - : Springer Nature. - 1265-4906 .- 1248-9204. ; 26:1, s. 61-73
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Tidskriftsartikel (refereegranskat)abstract
- Purpose Definitive fascial closure is an essential treatment objective after open abdomen treatment and mitigates morbidity and mortality. There is a paucity of evidence on factors that promote or prevent definitive fascial closure. Methods A multi-center multivariable analysis of data from the Open Abdomen Route of the European Hernia Society included all cases between 1 May 2015 and 31 December 2019. Different treatment elements, i.e. the use of a visceral protective layer, negative-pressure wound therapy and dynamic closure techniques, as well as patient characteristics were included in the multivariable analysis. The study was registered in the International Clinical Trials Registry Platform via the German Registry for Clinical Trials (DRK00021719). Results Data were included from 630 patients from eleven surgical departments in six European countries. Indications for OAT were peritonitis (46%), abdominal compartment syndrome (20.5%), burst abdomen (11.3%), abdominal trauma (9%), and other conditions (13.2%). The overall definitive fascial closure rate was 57.5% in the intention-to-treat analysis and 71% in the per-protocol analysis. The multivariable analysis showed a positive correlation of negative-pressure wound therapy (odds ratio: 2.496, p < 0.001) and dynamic closure techniques (odds ratio: 2.687, p < 0.001) with fascial closure and a negative correlation of intra-abdominal contamination (odds ratio: 0.630, p = 0.029) and the number of surgical procedures before OAT (odds ratio: 0.740, p = 0.005) with DFC. Conclusion The clinical course and prognosis of open abdomen treatment can significantly be improved by the use of treatment elements such as negative-pressure wound therapy and dynamic closure techniques, which are associated with definitive fascial closure.
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