| 1. |
|
|
| 2. |
- Bouyoucef, S E, et al.
(författare)
-
Poster Session 2 : Monday 4 May 2015, 08
- 2015
-
Ingår i: European Heart Journal Cardiovascular Imaging. - : Oxford University Press (OUP). - 2047-2404 .- 2047-2412. ; 16 Suppl 1
-
Tidskriftsartikel (refereegranskat)
|
|
| 3. |
- de Rojas, I., et al.
(författare)
-
Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores
- 2021
-
Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 12:1
-
Tidskriftsartikel (refereegranskat)abstract
- Genetic discoveries of Alzheimer’s disease are the drivers of our understanding, and together with polygenetic risk stratification can contribute towards planning of feasible and efficient preventive and curative clinical trials. We first perform a large genetic association study by merging all available case-control datasets and by-proxy study results (discovery n = 409,435 and validation size n = 58,190). Here, we add six variants associated with Alzheimer’s disease risk (near APP, CHRNE, PRKD3/NDUFAF7, PLCG2 and two exonic variants in the SHARPIN gene). Assessment of the polygenic risk score and stratifying by APOE reveal a 4 to 5.5 years difference in median age at onset of Alzheimer’s disease patients in APOE ɛ4 carriers. Because of this study, the underlying mechanisms of APP can be studied to refine the amyloid cascade and the polygenic risk score provides a tool to select individuals at high risk of Alzheimer’s disease. © 2021, The Author(s).
|
|
| 4. |
|
|
| 5. |
- Adrian-Kalchhauser, I., et al.
(författare)
-
The round goby genome provides insights into mechanisms that may facilitate biological invasions
- 2020
-
Ingår i: BMC Biology. - : Springer Science and Business Media LLC. - 1741-7007. ; 18:1
-
Tidskriftsartikel (refereegranskat)abstract
- Background The invasive benthic round goby (Neogobius melanostomus) is the most successful temperate invasive fish and has spread in aquatic ecosystems on both sides of the Atlantic. Invasive species constitute powerful in situ experimental systems to study fast adaptation and directional selection on short ecological timescales and present promising case studies to understand factors involved the impressive ability of some species to colonize novel environments. We seize the unique opportunity presented by the round goby invasion to study genomic substrates potentially involved in colonization success. Results We report a highly contiguous long-read-based genome and analyze gene families that we hypothesize to relate to the ability of these fish to deal with novel environments. The analyses provide novel insights from the large evolutionary scale to the small species-specific scale. We describe expansions in specific cytochrome P450 enzymes, a remarkably diverse innate immune system, an ancient duplication in red light vision accompanied by red skin fluorescence, evolutionary patterns of epigenetic regulators, and the presence of osmoregulatory genes that may have contributed to the round goby's capacity to invade cold and salty waters. A recurring theme across all analyzed gene families is gene expansions. Conclusions The expanded innate immune system of round goby may potentially contribute to its ability to colonize novel areas. Since other gene families also feature copy number expansions in the round goby, and since other Gobiidae also feature fascinating environmental adaptations and are excellent colonizers, further long-read genome approaches across the goby family may reveal whether gene copy number expansions are more generally related to the ability to conquer new habitats in Gobiidae or in fish.
|
|
| 6. |
- Vicente-Serrano, S. M., et al.
(författare)
-
Global Assessment of the Standardized Evapotranspiration Deficit Index (SEDI) for Drought Analysis and Monitoring
- 2018
-
Ingår i: Journal of Climate. - : American Meteorological Society. - 0894-8755 .- 1520-0442. ; 31:14, s. 5371-5393
-
Tidskriftsartikel (refereegranskat)abstract
- This article developed and implemented a new methodology for calculating the standardized evapotranspiration deficit index (SEDI) globally based on the log-logistic distribution to fit the evaporation deficit (ED), the difference between actual evapotranspiration (ETa) and atmospheric evaporative demand (AED). Our findings demonstrate that, regardless of the AED dataset used, a log-logistic distribution most optimally fitted the ED time series. As such, in many regions across the terrestrial globe, the SEDI is insensitive to the AED method used for calculation, with the exception of winter months and boreal regions. The SEDI showed significant correlations (p < 0.05) with the standardized precipitation evapotranspiration index (SPEI) across a wide range of regions, particularly for short (<3 month) SPEI time scales. This work provides a robust approach for calculating spatially and temporally comparable SEDI estimates, regardless of the climate region and land surface conditions, and it assesses the performance and the applicability of the SEDI to quantify drought severity across varying crop and natural vegetation areas.
|
|
| 7. |
- Vicente-Serrano, S. M., et al.
(författare)
-
Increased Vegetation in Mountainous Headwaters Amplifies Water Stress During Dry Periods
- 2021
-
Ingår i: Geophysical Research Letters. - 0094-8276. ; 48:18
-
Tidskriftsartikel (refereegranskat)abstract
- The dynamics of blue and green water partitioning under vegetation and climate change, as well as their different interactions during wet and dry periods, are poorly understood in the literature. We analyzed the impact of vegetation changes on blue water generation in a central Spanish Pyrenees basin undergoing intense afforestation. We found that vegetation change is a key driver of large decreases in blue water availability. The effect of vegetation increase is amplified during dry years, and mainly during the dry season, with streamflow reductions of more than 50%. This pattern can be attributed primarily to increased plant water consumption. Our findings highlight the importance of vegetation changes in reinforcing the decrease in water resource availability. With aridity expected to rise in southern Europe over the next few decades, interactions between climate and land management practices appear to be amplifying future hydrological drought risk in the region.
|
|
| 8. |
- Vicente-Serrano, S. M., et al.
(författare)
-
The complex multi-sectoral impacts of drought : Evidence from a mountainous basin in the Central Spanish Pyrenees
- 2021
-
Ingår i: Science of the Total Environment. - : Elsevier BV. - 0048-9697. ; 769
-
Tidskriftsartikel (refereegranskat)abstract
- We analyzed the impacts of drought severity on a variety of sectors in a topographically complex basin (the upper Aragón basin 2181 km2) in the Central Spanish Pyrenees. Using diverse data sources including meteorological and hydrological observations, remote sensing and tree rings, we analyze the possible hydrological implications of drought occurrence and severity on water availability in various sectors, including downstream impacts on irrigation water supply for crop production. Results suggest varying responses in forest activity, secondary growth, plant phenology, and crop yield to drought impacts. Specifically, meteorological droughts have distinct impacts downstream, mainly due to water partitioning between streamflow and irrigation channels that transport water to crop producing areas. This implies that drought severity can extend beyond the physical boundaries of the basin, with impacts on crop productivity. This complex response to drought impacts makes it difficult to develop objective basin-scale operational definitions for monitoring drought severity. Moreover, given the high spatial variability in responses to drought across sectors, it is difficult to establish reliable drought thresholds from indices that are relevant across all socio-economic sectors. The anthropogenic impacts (e.g. water regulation projects, ecosystem services, land cover and land use changes) pose further challenges to assessing the response of different systems to drought severity. This study stresses the need to consider the seasonality of drought impacts and appropriate drought time scales to adequately assess and understand their complexity.
|
|
