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- Burke, Catherine
(författare)
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The decorated school : Cross-disciplinary research in the history of art as integral to the design of educational environments
- 2013
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Ingår i: Paedagogica historica. - : Routledge. - 0030-9230 .- 1477-674X. ; 49:6, s. 813-827
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Tidskriftsartikel (refereegranskat)abstract
- This article reports on the opening up of a new, rich seam of interdisciplinaryresearch that brings together historians of education with historians of art andarchitecture to examine the meaning and incidence of“The Decorated School”.It examines the origins of the idea of art as educator in the nineteenth centuryand discusses how ideas about the education of taste accompanied theestablishment of mass education in industrialised nations during the early part ofthe twentieth century. Some examples of Decorated Schools in Britain andEurope are discussed with reference to the nature of the international andinterdisciplinary interpretation made possible by the research network. Finally,some of the challenges of interdisciplinary research in this area are presented, aswell as rich opportunities for further exploration. The article concludes that inorder to come closer to a realisation of how pupils might have experienced TheDecorated School in the past, we need to incorporate histories of children’splay-worlds in our project.
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- Chernomoretz, Ariel, et al.
(författare)
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The Metagenomics and Metadesign of the Subways and Urban Biomes (MetaSUB) International Consortium inaugural meeting report
- 2016
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Ingår i: Microbiome. - : Springer Science and Business Media LLC. - 2049-2618. ; 4
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Tidskriftsartikel (refereegranskat)abstract
- The Metagenomics and Metadesign of the Subways and Urban Biomes (MetaSUB) International Consortium is a novel, interdisciplinary initiative comprised of experts across many fields, including genomics, data analysis, engineering, public health, and architecture. The ultimate goal of the MetaSUB Consortium is to improve city utilization and planning through the detection, measurement, and design of metagenomics within urban environments. Although continual measures occur for temperature, air pressure, weather, and human activity, including longitudinal, cross-kingdom ecosystem dynamics can alter and improve the design of cities. The MetaSUB Consortium is aiding these efforts by developing and testing metagenomic methods and standards, including optimized methods for sample collection, DNA/RNA isolation, taxa characterization, and data visualization. The data produced by the consortium can aid city planners, public health officials, and architectural designers. In addition, the study will continue to lead to the discovery of new species, global maps of antimicrobial resistance (AMR) markers, and novel biosynthetic gene clusters (BGCs). Finally, we note that engineered metagenomic ecosystems can help enable more responsive, safer, and quantified cities.
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Engaging with Educational Space : Visualizing Spaces of Teaching and Learning
- 2014
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Samlingsverk (redaktörskap) (övrigt vetenskapligt/konstnärligt)abstract
- This book weaves together two central dimensions of contemporary educational research, namely the attention to school spaces and the use of visual sources. Its sixteen brief case studies deal with both contemporary and historical settings, topics including teachers’ perception of educational change, their working places and daily tasks, the interlacing of social, spatial and knowledge differentiation in schools, discrepancies between students’ and teachers’ ways of visualizing school life, commercial representations of the school environment and the spatial fluidity between indoor and outdoor. The ongoing technology shift and its impact on schooling is an undercurrent running through the entire volume.The authors – the majority of whom are practicing teachers – are Ulrika Boström, Maria Deldén, Carl Emanuelsson, Catharina Hultkrantz, Aleksandra Indzic Dujso, Cecilia Johansson, Kristina Ledman, Synne Myreböe, Lena Almqvist Nielsen, Peter Norlander, Annie Olsson, Karin Sandberg, Lina Spjut, Robert Thorp, Åsa Wendin and Andreas Westerberg. The book is edited and introduced by Catherine Burke, Ian Grosvenor and Björn Norlin.Engaging with Educational Space is suitable to both academic courses focusing on methodological issues associated with the study of school spaces and to the use of visual sources in educational research, and for the in-service training of teachers and other individuals involved in education.
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- Fresard, Laure, et al.
(författare)
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Identification of rare-disease genes using blood transcriptome sequencing and large control cohorts
- 2019
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Ingår i: Nature Medicine. - : NATURE PUBLISHING GROUP. - 1078-8956 .- 1546-170X. ; 25:6, s. 911-919
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Tidskriftsartikel (refereegranskat)abstract
- It is estimated that 350 million individuals worldwide suffer from rare diseases, which are predominantly caused by mutation in a single gene(1). The current molecular diagnostic rate is estimated at 50%, with whole-exome sequencing (WES) among the most successful approaches(2-5). For patients in whom WES is uninformative, RNA sequencing (RNA-seq) has shown diagnostic utility in specific tissues and diseases(6-8). This includes muscle biopsies from patients with undiagnosed rare muscle disorders(6,9), and cultured fibroblasts from patients with mitochondrial disorders(7). However, for many individuals, biopsies are not performed for clinical care, and tissues are difficult to access. We sought to assess the utility of RNA-seq from blood as a diagnostic tool for rare diseases of different pathophysiologies. We generated whole-blood RNA-seq from 94 individuals with undiagnosed rare diseases spanning 16 diverse disease categories. We developed a robust approach to compare data from these individuals with large sets of RNA-seq data for controls (n = 1,594 unrelated controls and n = 49 family members) and demonstrated the impacts of expression, splicing, gene and variant filtering strategies on disease gene identification. Across our cohort, we observed that RNA-seq yields a 7.5% diagnostic rate, and an additional 16.7% with improved candidate gene resolution.
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| 7. |
- Hirst, Catherine, et al.
(författare)
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Characterisation of Fe-bearing particles and colloids in the Lena River basin, NE Russia
- 2017
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Ingår i: Geochimica et Cosmochimica Acta. - Cambridge : Elsevier. - 0016-7037 .- 1872-9533. ; 213, s. 553-573
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Tidskriftsartikel (refereegranskat)abstract
- Rivers are significant contributors of Fe to theocean. However, the characteristics of chemically reactive Fe remain poorly constrained, especially in large Arctic rivers, which drain landscapes highly susceptible to climate change and carbon cycle alteration. The aim of this study was a detailed characterisation (size, mineralogy, and speciation) of riverine Fe-bearing particles (> 0.22 µm) and colloids (1 kDa – 0.22 µm) and their association with organic carbon (OC), in the Lena River and tributaries, which drain a catchment almost entirely underlain by permafrost. Samples fromthe main channel and tributaries representing watersheds that span a wide rangein topography and lithology were taken after the spring flood in June 2013 and summer baseflow in July 2012. Fe-bearing particles were identified, usingTransmission Electron Microscopy, as large (200 nm – 1 µm) aggregates of smaller (20 nm - 30 nm) spherical colloids of chemically-reactive ferrihydrite.In contrast, there were also large (500 nm – 1 µm) aggregates of clay (illite) particles and smaller (100 - 200 nm) iron oxide particles (dominantly hematite) that contain poorly reactive Fe. TEM imaging and Scanning Transmission X-raymicroscopy (STXM) indicated that the ferrihydrite is present as discrete particles within networks of amorphous particulate organic carbon (POC) and attached to the surface of primary produced organic matter and clay particles.Together, these larger particles act as the main carriers of nanoscale ferrihydrite in the Lena River basin. The chemically reactive ferrihydrite accounts for on average 70 ± 15 % of the total suspended Fe in the Lena River and tributaries. These observations place important constraints on Fe and OC cycling in the Lena River catchment area and Fe-bearing particle transport to the Arctic Ocean.
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| 8. |
- Hudson, Thomas J., et al.
(författare)
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International network of cancer genome projects
- 2010
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 464:7291, s. 993-998
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Tidskriftsartikel (refereegranskat)abstract
- The International Cancer Genome Consortium (ICGC) was launched to coordinate large-scale cancer genome studies in tumours from 50 different cancer types and/or subtypes that are of clinical and societal importance across the globe. Systematic studies of more than 25,000 cancer genomes at the genomic, epigenomic and transcriptomic levels will reveal the repertoire of oncogenic mutations, uncover traces of the mutagenic influences, define clinically relevant subtypes for prognosis and therapeutic management, and enable the development of new cancer therapies.
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- Maxwell, Tania L., et al.
(författare)
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Global dataset of soil organic carbon in tidal marshes
- 2023
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Ingår i: Scientific Data. - : Springer Nature. - 2052-4463. ; 10:1
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Tidskriftsartikel (refereegranskat)abstract
- Tidal marshes store large amounts of organic carbon in their soils. Field data quantifying soil organic carbon (SOC) stocks provide an important resource for researchers, natural resource managers, and policy-makers working towards the protection, restoration, and valuation of these ecosystems. We collated a global dataset of tidal marsh soil organic carbon (MarSOC) from 99 studies that includes location, soil depth, site name, dry bulk density, SOC, and/or soil organic matter (SOM). The MarSOC dataset includes 17,454 data points from 2,329 unique locations, and 29 countries. We generated a general transfer function for the conversion of SOM to SOC. Using this data we estimated a median (± median absolute deviation) value of 79.2 ± 38.1 Mg SOC ha−1 in the top 30 cm and 231 ± 134 Mg SOC ha−1 in the top 1 m of tidal marsh soils globally. This data can serve as a basis for future work, and may contribute to incorporation of tidal marsh ecosystems into climate change mitigation and adaptation strategies and policies.
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