| 1. |
- Abramowicz, Marek A, 1945, et al.
(författare)
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The correlations and anticorrelations in QPO data
- 2005
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Ingår i: Astronomische Nachrichten. - : Wiley. - 0004-6337 .- 1521-3994. ; 326:9, s. 864-866
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Tidskriftsartikel (refereegranskat)abstract
- Double peak kHz QPO frequencies in neutron star sources varies in time by a factor of hundreds Hz while in microquasar sources the frequencies are fixed and located at the line ν2 - ν1 in the frequency-frequency plot. The crucial question in the theory of twin HFQPOs is whether or not those observed in neutron-star systems are essentially different from those observed in black holes. In black hole systems the twin HFQPOs are known to be in a 3:2 ratio for each source. At first sight, this seems not to be the case for neutron stars. For each individual neutron star, the upper and lower kHz QPO frequencies, ν2 and ν1, are linearly correlated, ν2 = ν1 + B, with the slope A < 1.5, i.e., the frequencies definitely are not in a 1.5 ratio. In this contribution we show that when considered jointly on a frequency-frequency plot, the data for the twin kHz QPO frequencies in several (as opposed to one) neutron stars uniquely pick out a certain preferred frequency ratio that is equal to 1.5 for the six sources examined so far.
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| 2. |
- Georgoulas, George, et al.
(författare)
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An exploratory approach to fetal heart rate–pH-based systems
- 2021
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Ingår i: Signal, Image and Video Processing. - : Springer. - 1863-1703 .- 1863-1711. ; 15:1, s. 43-51
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Tidskriftsartikel (refereegranskat)abstract
- This paper presents an exploratory approach of the fetal heart rate (FHR) analysis, aiming to highlight potential limitations of the current predictive modeling attempts. To do so, a set of features that are usually encountered in FHR analysis as well as features extracted using a variant of symbolic aggregate approximation were projected onto a lower-dimensional space where patterns can easily be discerned. The results show, both in a qualitative and a quantitative manner, that there is high overlap between the classes that are formed using solely the umbilical cord pH information, irrespective of the selected dimensionality reduction method. These findings suggest that there is probably a limit to the performance expectation of the current pH-based systems and that alternative approaches should be also pursued to enhance the utility of computer-based decision support technologies.
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| 3. |
- Polzer, Stanislav, et al.
(författare)
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A Numerical Implementation to Predict Residual Strains from the Homogeneous Stress Hypothesis with Application to Abdominal Aortic Aneurysms
- 2013
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Ingår i: Annals of Biomedical Engineering. - : Springer Science and Business Media LLC. - 0090-6964 .- 1573-9686. ; 41:7, s. 1516-1527
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Tidskriftsartikel (refereegranskat)abstract
- Wall stress analysis of abdominal aortic aneurysm (AAA) is a promising method of identifying AAAs at high risk of rupture. However, neglecting residual strains (RS) in the load-free configuration of patient-specific finite element analysis models is a sever limitation that strongly affects the computed wall stresses. Although several methods for including RS have been proposed, they cannot be directly applied to patient-specific AAA simulations. RS in the AAA wall are predicted through volumetric tissue growth that aims at satisfying the homogeneous stress hypothesis at mean arterial pressure load. Tissue growth is interpolated linearly across the wall thickness and aneurysm tissues are described by isotropic constitutive formulations. The total deformation is multiplicatively split into elastic and growth contributions, and a staggered schema is used to solve the field variables. The algorithm is validated qualitatively at a cylindrical artery model and then applied to patient-specific AAAs (n = 5). The induced RS state is fully three-dimensional and in qualitative agreement with experimental observations, i.e., wall strips that were excised from the load-free wall showed stress-releasing-deformations that are typically seen in laboratory experiments. Compared to RS-free simulations, the proposed algorithm reduced the von Mises stress gradient across the wall by a tenfold. Accounting for RS leads to homogenized wall stresses, which apart from reducing the peak wall stress (PWS) also shifted its location in some cases. The present study demonstrated that the homogeneous stress hypothesis can be effectively used to predict RS in the load-free configuration of the vascular wall. The proposed algorithm leads to a fast and robust prediction of RS, which is fully capable for a patient-specific AAA rupture risk assessment. Neglecting RS leads to non-realistic wall stress values that severely overestimate the PWS.
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| 4. |
- Polzer, Stanislav, et al.
(författare)
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Biomechanical indices are more sensitive than diameter in predicting rupture of asymptomatic abdominal aortic aneurysms
- 2020
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Ingår i: Journal of Vascular Surgery. - : MOSBY-ELSEVIER. - 0741-5214 .- 1097-6809. ; 71:2, s. 617-
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Tidskriftsartikel (refereegranskat)abstract
- Objective: Several studies of biomechanical rupture risk assessment (BRRA) showed its advantage over the diameter criterion in rupture risk assessment of abdominal aortic aneurysm (AAA). However, BRRA studies have not investigated the predictability of biomechanical risk indices at different time points ahead of rupture, nor have they been performed blinded for biomechanical analysts. The objective of this study was to test the predictability of the BRRA method against diameter-based risk indices in a quasi-prospective patient cohort study.Methods: In total, 12 women and 31 men with intact AAAs at baseline have been selected retrospectively at two medical centers. Within 56 months, 19 cases ruptured, whereas 24 cases remained intact within 2 to 56 months. This outcome was kept confidential until all biomechanical activities in this study were finished. The biomechanical AAA rupture risk was calculated at baseline using high-fidelity and low-fidelity finite element method models. The capability of biomechanics-based and diameter-based risk indices to predict the known outcomes at 1 month, 3 months, 6 months, 9 months, and 12 months after baseline was validated. Besides common cohort statistics, the area under the curve (AUC) of receiver operating characteristic curves has been used to grade the different rupture risk indices.Results: Up to 9 months ahead of rupture, the receiver operating characteristic analysis of biomechanics-based risk indices showed a higher AUC than diameter-based indices. Six months ahead of rupture, the largest difference was observed with an AUC of 0.878 for the high-fidelity biomechanical risk index, 0.859 for the low-fidelity biomechanical risk index, 0.789 for the diameter, and 0.821 for the sex-adjusted diameter. In predictions beyond 9 months, none of the risk indices proved to be superior.Conclusions: High-fidelity biomechanical modeling improves the predictability of AAA rupture. Asymptomatic AAA patients with high biomechanical AAA rupture risk indices have an increased risk of rupture. Integrating biomechanics-based diagnostic indices may significantly decrease the false-positive rate in AAA treatment.
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| 5. |
- Polzer, Stanislav, et al.
(författare)
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Impact of poroelasticity of intraluminal thrombus on wall stress of abdominal aortic aneurysms
- 2012
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Ingår i: Biomedical engineering online. - 1475-925X. ; 11, s. 62-
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Tidskriftsartikel (refereegranskat)abstract
- Background: The predictions of stress fields in Abdominal Aortic Aneurysm (AAA) depend on constitutive descriptions of the aneurysm wall and the Intra-luminal Thrombus (ILT). ILT is a porous diluted structure (biphasic solid-fluid material) and its impact on AAA biomechanics is controversially discussed in the literature. Specifically, pressure measurements showed that the ILT cannot protect the wall from the arterial pressure, while other (numerical and experimental) studies showed that at the same time it reduces the stress in the wall. Method: To explore this phenomenon further a poroelastic description of the ILT was integrated in Finite Element (FE) Models of the AAA. The AAA model was loaded by a pressure step and a cyclic pressure wave and their transition into wall tension was investigated. To this end ILT's permeability was varied within a microstructurally motivated range. Results: The two-phase model verified that the ILT transmits the entire mean arterial pressure to the wall while, at the same time, it significantly reduces the stress in the wall. The predicted mean stress in the AAA wall was insensitive to the permeability of the ILT and coincided with the results of AAA models using a single-phase ILT description. Conclusion: At steady state, the biphasic ILT behaves like a single-phase material in an AAA model. Consequently, computational efficient FE single-phase models, as they have been exclusively used in the past, accurately predict the wall stress in AAA models.
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