| 2. |
- Khodabukus, A, et al.
(författare)
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Translating musculoskeletal bioengineering into tissue regeneration therapies
- 2022
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Ingår i: Science translational medicine. - : American Association for the Advancement of Science (AAAS). - 1946-6242 .- 1946-6234. ; 14:666, s. eabn9074-
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Tidskriftsartikel (refereegranskat)abstract
- Musculoskeletal injuries and disorders are the leading cause of physical disability worldwide and a considerable socioeconomic burden. The lack of effective therapies has driven the development of novel bioengineering approaches that have recently started to gain clinical approvals. In this review, we first discuss the self-repair capacity of the musculoskeletal tissues and describe causes of musculoskeletal dysfunction. We then review the development of novel biomaterial, immunomodulatory, cellular, and gene therapies to treat musculoskeletal disorders. Last, we consider the recent regulatory changes and future areas of technological progress that can accelerate translation of these therapies to clinical practice.
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| 3. |
- Petric, Zvonimir, et al.
(författare)
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(DYS) FUNCTIONALITY OF PROBIOTICS IN FOOD PRODUCTS
- 2021
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Ingår i: In Vitro Functionality of Probiotics in Foods. - 9781685073220 ; , s. 163-202
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Bokkapitel (refereegranskat)abstract
- The aim of this chapter is to provide an overview of the advantages and disadvantages of consuming probiotics and using them as raw materials for the production of functional foods (fruit juices) and nutraceuticals. The consumption of probiotics in traditional diets has a long tradition, while recent industrial and scientific developments, together with consumer interests, have promoted the increasing production of functional foods in which probiotics are considered a source of health benefits. For example, probiotics are added to fruit juices, which are then classified as a new type of functional food. The addition of probiotics to juices could improve their nutritional value while making the health properties of both sources available to consumers, e.g., the absorption of biologically active compounds from fruits and vegetables and probiotics. Another industrial (pharmaceutical) application of probiotics, which also has great economic potential, is the production of dietary supplements (e.g., nutraceuticals) in the form of capsules, liquids, powders and tablets. In general, probiotic products appear to be safe for consumption, but there is little evidence to confirm their safety. For the same reason, a legal framework could better ensure consumer safety, especially considering that uncontrolled consumption of probiotics could have dire consequences for vulnerable populations. In addition to the evidence-based regulatory framework, the food industry and the academic community should find ways to preserve the sensory properties of the final products and the viability of probiotic microorganisms during manufacturing, storage and digestion. In this way, functional aspects and health claims on food labels should provide consumers with clear and unambiguous messages about what kind of food they are really consuming.
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