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Sökning: WFRF:(Bushman F)

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1.
  • Costea, P. I., et al. (författare)
  • Enterotypes in the landscape of gut microbial community composition
  • 2018
  • Ingår i: Nature Microbiology. - : Springer Science and Business Media LLC. - 2058-5276. ; 3:1
  • Tidskriftsartikel (refereegranskat)abstract
    • Population stratification is a useful approach for a better understanding of complex biological problems in human health and wellbeing. The proposal that such stratification applies to the human gut microbiome, in the form of distinct community composition types termed enterotypes, has been met with both excitement and controversy. In view of accumulated data and re-analyses since the original work, we revisit the concept of enterotypes, discuss different methods of dividing up the landscape of possible microbiome configurations, and put these concepts into functional, ecological and medical contexts. As enterotypes are of use in describing the gut microbial community landscape and may become relevant in clinical practice, we aim to reconcile differing views and encourage a balanced application of the concept.
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2.
  • Kennedy, K. M., et al. (författare)
  • Questioning the fetal microbiome illustrates pitfalls of low-biomass microbial studies
  • 2023
  • Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 613:7945, s. 639-649
  • Tidskriftsartikel (refereegranskat)abstract
    • Whether the human fetus and the prenatal intrauterine environment (amniotic fluid and placenta) are stably colonized by microbial communities in a healthy pregnancy remains a subject of debate. Here we evaluate recent studies that characterized microbial populations in human fetuses from the perspectives of reproductive biology, microbial ecology, bioinformatics, immunology, clinical microbiology and gnotobiology, and assess possible mechanisms by which the fetus might interact with microorganisms. Our analysis indicates that the detected microbial signals are likely the result of contamination during the clinical procedures to obtain fetal samples or during DNA extraction and DNA sequencing. Furthermore, the existence of live and replicating microbial populations in healthy fetal tissues is not compatible with fundamental concepts of immunology, clinical microbiology and the derivation of germ-free mammals. These conclusions are important to our understanding of human immune development and illustrate common pitfalls in the microbial analyses of many other low-biomass environments. The pursuit of a fetal microbiome serves as a cautionary example of the challenges of sequence-based microbiome studies when biomass is low or absent, and emphasizes the need for a trans-disciplinary approach that goes beyond contamination controls by also incorporating biological, ecological and mechanistic concepts.
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4.
  • Williams, B, et al. (författare)
  • A Summary of the Second Annual HIV Microbiome Workshop
  • 2017
  • Ingår i: AIDS research and human retroviruses. - : Mary Ann Liebert Inc. - 1931-8405 .- 0889-2229. ; 33:12, s. 1258-1264
  • Forskningsöversikt (övrigt vetenskapligt/konstnärligt)
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5.
  • Williams, B, et al. (författare)
  • A Summary of the Third Annual HIV Microbiome Workshop
  • 2018
  • Ingår i: AIDS research and human retroviruses. - : Mary Ann Liebert Inc. - 1931-8405 .- 0889-2229. ; 34:10, s. 828-834
  • Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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  • Resultat 1-5 av 5

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