| 1. |
- Jin, Young Hoon, et al.
(författare)
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Wavelet decomposition for detection of chaotic characteristics of monthly precipitation at Mokpo, Korea
- 2005
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Ingår i: 31st IAHR Congress 2005 : Water Engineering for the Future, Choices and Challenges - Water Engineering for the Future, Choices and Challenges. - 8987898245 - 9788987898247 ; , s. 429-437
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Konferensbidrag (refereegranskat)abstract
- In the present study, we apply deterministic chaos theory to investigate nonlinear dynamics in monthly precipitation at Mokpo, Korea, after wavelet decomposition. The wavelet transform is used not only for removal of noise but also for extraction of low and high frequency components in the data, representing low-dimensional dynamics. In order to determine an appropriate decomposition level for the wavelet transform, a correlation dimension analysis is applied for the respective low and high frequency signals after successive decomposition. The wavelet decomposition is performed up to 5th-level with orthogonal and compactly supported wavelets. Consequently, a long-term approximation (low frequency) and a short-term detail (high frequency) time series for the monthly precipitation obtained after 5th-level decomposition are investigated in terms of deterministic chaos theory. The data sets with low/high frequency components filtered by the wavelet transform are used for three-dimensional phase space analysis, respectively. Results show that both low and high frequency signals include clear chaotic signals and, therefore, might be governed by underlying dynamics based on different frequencies, respectively.
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| 2. |
- Lee, Jun Ho, et al.
(författare)
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The Anti-Inflammatory Effects of Adipose Tissue Mesenchymal Stem Cell Exosomes in a Mouse Model of Inflammatory Bowel Disease
- 2023
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Ingår i: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. - 1661-6596 .- 1422-0067. ; 24:23
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Tidskriftsartikel (refereegranskat)abstract
- Inflammatory bowel disease (IBD) is a group of chronic, relapsing inflammatory disorders that affect the gastrointestinal tract, with the primary subtypes being ulcerative colitis (UC) and Crohn's disease (CD). We aimed to evaluate the therapeutic potential of extracellular vesicles released by adipose-tissue-derived mesenchymal stem cells, which we, in this manuscript, call "exosomes" (ASC-EXOs), in a mouse model of IBD. We specifically aimed to determine the effectiveness of different treatment protocols and compare the effects with that of anti-IL-12 p40 monoclonal antibody. The addition of dextran sulfate sodium (DSS) to drinking water induced multiple signs of IBD, including weight loss, soft stool, and bloody feces. ASC-EXOs given by either intraperitoneal (IP) or intravenous (IV) routes resulted in moderate improvement in these signs of IBD. IV ASC-EXOs resulted in significantly reduced body weight loss, improved histopathological scoring, and suppressed the disease activity index (DAI) compared to the IBD control group. Also, a reduction in PCR for pro-inflammatory cytokines was observed. IV ASC treatment resulted in dose-related reduction in IBD signs, including weight loss. An increasing number of injections with ASC-EXOs reduced histopathological scores as well as DAI. Co-administration of ASC-EXOs with anti-IL-12 p40 significantly decreased DAI scores in the ASC-EXO + anti-IL-12 p40 group. In conclusion, ASC-EXOs have potential as a therapeutic agent for IBD, but the route of administration, number of injections, and dosage need to be considered to optimize the effects of ASC-EXO treatment. This study also highlights the potential benefits of combination therapies of ASC-EXOs and anti-IL-12. Our findings pave the way for further studies to unravel the underlying therapeutic mechanisms of ASC-EXOs in IBD treatment.
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