| 1. |
- Alex-Amor, Antonio, et al.
(författare)
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Dispersion Analysis of Periodic Structures in Anisotropic Media : Application to Liquid Crystals
- 2022
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Ingår i: IEEE Transactions on Antennas and Propagation. - : Institute of Electrical and Electronics Engineers (IEEE). - 0018-926X .- 1558-2221. ; 70:4, s. 2811-2821
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Tidskriftsartikel (refereegranskat)abstract
- This article presents an efficient method to compute the dispersion diagram of periodic and uniform structures with generic anisotropic media. The method takes advantage of the ability of full-wave commercial simulators to deal with finite structures having anisotropic media. In particular, the proposed method extends the possibilities of commercial eigenmode solvers in the following ways: 1) anisotropic materials with nondiagonal permittivity and permeability tensors can be analyzed; 2) the attenuation constant can easily be computed in both propagating and stopband regions, and lossy materials can be included in the simulation; and 3) unbounded and radiating structures, such as leaky-wave antennas (LWAs), can be treated. The latter feature may be considered the most remarkable since the structures must be forcefully bounded with electric/magnetic walls in the eigensolvers of most commercial simulators. In this work, the proposed method is particularized for the study of liquid crystals (LCs) in microwave and antenna devices. Thus, the dispersion properties of a great variety of LC-based configurations are analyzed, from canonical structures, such as waveguide and microstrip, to complex reconfigurable phase shifters in ridge gap-waveguide technology and LWAs. Our results have been validated with previously reported works in the literature and with commercial software CST and HFSS.
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| 2. |
- Beal, Jacob, et al.
(författare)
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Robust estimation of bacterial cell count from optical density
- 2020
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Ingår i: Communications Biology. - : Springer Science and Business Media LLC. - 2399-3642. ; 3:1
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Tidskriftsartikel (refereegranskat)abstract
- Optical density (OD) is widely used to estimate the density of cells in liquid culture, but cannot be compared between instruments without a standardized calibration protocol and is challenging to relate to actual cell count. We address this with an interlaboratory study comparing three simple, low-cost, and highly accessible OD calibration protocols across 244 laboratories, applied to eight strains of constitutive GFP-expressing E. coli. Based on our results, we recommend calibrating OD to estimated cell count using serial dilution of silica microspheres, which produces highly precise calibration (95.5% of residuals <1.2-fold), is easily assessed for quality control, also assesses instrument effective linear range, and can be combined with fluorescence calibration to obtain units of Molecules of Equivalent Fluorescein (MEFL) per cell, allowing direct comparison and data fusion with flow cytometry measurements: in our study, fluorescence per cell measurements showed only a 1.07-fold mean difference between plate reader and flow cytometry data.
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| 3. |
- Caronna, Edoardo, et al.
(författare)
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Redefining migraine prevention: early treatment with anti-CGRP monoclonal antibodies enhances response in the real world
- 2024
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Ingår i: JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY. - 0022-3050 .- 1468-330X.
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Tidskriftsartikel (refereegranskat)abstract
- Background Anti-CGRP monoclonal antibodies (anti-CGRP MAbs) are approved and available treatments for migraine prevention. Patients do not respond alike and many countries have reimbursement policies, which hinder treatments to those who might respond. This study aimed to investigate clinical factors associated with good and excellent response to anti-CGRP MAbs at 6 months. Methods European multicentre, prospective, real-world study, including high-frequency episodic or chronic migraine (CM) patients treated since March 2018 with anti-CGRP MAbs. We defined good and excellent responses as >= 50% and >= 75% reduction in monthly headache days (MHD) at 6 months, respectively. Generalised mixed-effect regression models (GLMMs) were used to identify variables independently associated with treatment response. Results Of the 5818 included patients, 82.3% were females and the median age was 48.0 (40.0-55.0) years. At baseline, the median of MHD was 20.0 (14.0-28.0) days/months and 72.2% had a diagnosis of CM. At 6 months (n=4963), 56.5% (2804/4963) were good responders and 26.7% (1324/4963) were excellent responders. In the GLMM model, older age (1.08 (95% CI 1.02 to 1.15), p=0.016), the presence of unilateral pain (1.39 (95% CI 1.21 to 1.60), p<0.001), the absence of depression (0.840 (95% CI 0.731 to 0.966), p=0.014), less monthly migraine days (0.923 (95% CI 0.862 to 0.989), p=0.023) and lower Migraine Disability Assessment at baseline (0.874 (95% CI 0.819 to 0.932), p<0.001) were predictors of good response (AUC of 0.648 (95% CI 0.616 to 0.680)). These variables were also significant predictors of excellent response (AUC of 0.691 (95% CI 0.651 to 0.731)). Sex was not significant in the GLMM models. Conclusions This is the largest real-world study of migraine patients treated with anti-CGRP MAbs. It provides evidence that higher migraine frequency and greater disability at baseline reduce the likelihood of responding to anti-CGRP MAbs, informing physicians and policy-makers on the need for an earlier treatment in order to offer the best chance of treatment success.
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| 4. |
- Chen, Qiao, et al.
(författare)
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Glide-Symmetric Holey Leaky-Wave Antenna With Low Dispersion for 60 GHz Point-to-Point Communications
- 2020
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Ingår i: IEEE Transactions on Antennas and Propagation. - : Institute of Electrical and Electronics Engineers (IEEE). - 0018-926X .- 1558-2221. ; 68:3, s. 1925-1936
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Tidskriftsartikel (refereegranskat)abstract
- In this article, two novel efficient leaky-wave antennas (LWAs) with stable radiation patterns operating in the 60 GHz band are proposed. The LWAs are implemented in groove-gap waveguide (GGW) technology. To mitigate the beam squint due to the dispersive nature of LWAs, complementary-dispersive prisms are coupled to the LWA radiation aperture. The antennas are implemented in fully metallic purely holey periodic structures, resulting in a more cost-effective and robust manufacturing process compared to previously reported pin-based structures. Two prisms are proposed, one with mirror symmetry and one with glide symmetry. When the prism possesses a glide symmetry, much fewer holes are required while maintaining a similar performance, which even further decreases the fabrication costs. The complex propagation constant is optimized for low sidelobe levels (SLLs) with tailored hole diameters and waveguide dimensions, thus for the first time demonstrating the capability of using glide-symmetric holes to control the leakage rate. Two prototypes with mirror- and glide-symmetric prisms are theoretically synthesized and validated by the simulated and experimental results. A frequency bandwidth of 11% is achieved for both prototypes with the beam squint within +/- 0.9 degrees (mirror) and +/- 1.7 degrees (glide), SLLs below -15 dB (mirror) and -13 dB (glide), total efficiency almost 90%, and realized gain of 17 +/- 0.5 dB at a fixed observing angle. The developed antennas are intended for mm-wave point-to-point communications.
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| 5. |
- Chen, Qiao, et al.
(författare)
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Prism-based Leaky-Lens Antennas at 60 GHz for 5G Point-to-Point Communication Links
- 2020
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Ingår i: 2020 14TH EUROPEAN CONFERENCE ON ANTENNAS AND PROPAGATION (EUCAP 2020). - : IEEE.
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Konferensbidrag (refereegranskat)abstract
- Two cost-effective implementations of a leaky-lens antenna at 60 GHz are proposed for high-throughput 5G communication links. The leaky-wave feed is realized in gap-waveguide technology, where the radiation from the slit is controlled with glide-symmetric holes. The beam-squint of the leaky-wave radiation is mitigated, owing to the coupling of a complementary dispersive prism. Here, two prisms are implemented, one with glide-symmetric holes, and another with substrate-integrated holes (SIHs), both integrated in parallel plates with the leaky wave feeding. Thanks to glide symmetry, better control of the leakage rate, lower costs, and better tolerance to manufacturing are achieved in comparison with the non-glide holey counterpart. In addition, the SIH-based design exhibits a substantially enhanced bandwidth with even better robustness. In the analysis of the leaky-wave feed, more accuracy and reduced computational time is achieved by using a multi-mode method. Both antennas show stable radiation patterns, featuring high efficiency, high gain, and low side lobe levels.
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| 6. |
- Delgado-Lista, Javier, et al.
(författare)
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Top Single Nucleotide Polymorphisms Affecting Carbohydrate Metabolism in Metabolic Syndrome : From the LIPGENE Study
- 2014
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Ingår i: Journal of Clinical Endocrinology and Metabolism. - : The Endocrine Society. - 0021-972X .- 1945-7197. ; 99:2, s. E384-E389
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Tidskriftsartikel (refereegranskat)abstract
- Rationale: Metabolic syndrome (MetS) is a high-prevalence condition characterized by altered energy metabolism, insulin resistance, and elevated cardiovascular risk. Objectives: Although many individual single nucleotide polymorphisms (SNPs) have been linked to certain MetS features, there are few studies analyzing the influence of SNPs on carbohydrate metabolism in MetS. Methods: A total of 904 SNPs (tag SNPs and functional SNPs) were tested for influence on 8 fasting and dynamic markers of carbohydrate metabolism, by performance of an intravenous glucose tolerance test in 450 participants in the LIPGENE study. Findings: From 382 initial gene-phenotype associations between SNPs and any phenotypic variables, 61 (16% of the preselected variables) remained significant after bootstrapping. Top SNPs affecting glucose metabolism variables were as follows: fasting glucose, rs26125 (PPARGC1B); fasting insulin, rs4759277 (LRP1); C-peptide, rs4759277 (LRP1); homeostasis assessment of insulin resistance, rs4759277 (LRP1); quantitative insulin sensitivity check index, rs184003 (AGER); sensitivity index, rs7301876 (ABCC9), acute insulin response to glucose, rs290481 (TCF7L2); and disposition index, rs12691 (CEBPA). Conclusions: We describe here the top SNPs linked to phenotypic features in carbohydrate metabolism among approximately 1000 candidate gene variations in fasting and postprandial samples of 450 patients with MetS from the LIPGENE study.
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| 9. |
- Jin, Shoko, et al.
(författare)
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The wide-field, multiplexed, spectroscopic facility WEAVE : Survey design, overview, and simulated implementation
- 2024
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Ingår i: Monthly notices of the Royal Astronomical Society. - : Oxford University Press. - 0035-8711 .- 1365-2966. ; 530:3, s. 2688-2730
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Tidskriftsartikel (refereegranskat)abstract
- WEAVE, the new wide-field, massively multiplexed spectroscopic survey facility for the William Herschel Telescope, saw first light in late 2022. WEAVE comprises a new 2-deg field-of-view prime-focus corrector system, a nearly 1000-multiplex fibre positioner, 20 individually deployable 'mini' integral field units (IFUs), and a single large IFU. These fibre systems feed a dual-beam spectrograph covering the wavelength range 366-959nm at R similar to 5000, or two shorter ranges at . After summarizing the design and implementation of WEAVE and its data systems, we present the organization, science drivers, and design of a five- to seven-year programme of eight individual surveys to: (i) study our Galaxy's origins by completing Gaia's phase-space information, providing metallicities to its limiting magnitude for similar to 3 million stars and detailed abundances for similar to 1.5 million brighter field and open-cluster stars; (ii) survey similar to 0.4 million Galactic-plane OBA stars, young stellar objects, and nearby gas to understand the evolution of young stars and their environments; (iii) perform an extensive spectral survey of white dwarfs; (iv) survey similar to 400 neutral-hydrogen-selected galaxies with the IFUs; (v) study properties and kinematics of stellar populations and ionized gas in z < 0.5 cluster galaxies; (vi) survey stellar populations and kinematics in field galaxies at 0.3 less than or similar to z less than or similar to 0.7; (vii) study the cosmic evolution of accretion and star formation using >1 million spectra of LOFAR-selected radio sources; and (viii) trace structures using intergalactic/circumgalactic gas at z > 2. Finally, we describe the WEAVE Operational Rehearsals using the WEAVE Simulator.
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| 10. |
- Otero, Jaime, et al.
(författare)
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Basin-scale phenology and effects of climate variability on global timing of initial seaward migration of Atlantic salmon (Salmo salar)
- 2014
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Ingår i: Global Change Biology. - : Wiley. - 1354-1013 .- 1365-2486. ; 20:1, s. 61-75
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Tidskriftsartikel (refereegranskat)abstract
- Migrations between different habitats are key events in the lives of many organisms. Such movements involve annually recurring travel over long distances usually triggered by seasonal changes in the environment. Often, the migration is associated with travel to or from reproduction areas to regions of growth. Young anadromous Atlantic salmon (Salmo salar) emigrate from freshwater nursery areas during spring and early summer to feed and grow in the North Atlantic Ocean. The transition from the freshwater ('parr') stage to the migratory stage where they descend streams and enter salt water ('smolt') is characterized by morphological, physiological and behavioural changes where the timing of this parr-smolt transition is cued by photoperiod and water temperature. Environmental conditions in the freshwater habitat control the downstream migration and contribute to within- and among-river variation in migratory timing. Moreover, the timing of the freshwater emigration has likely evolved to meet environmental conditions in the ocean as these affect growth and survival of the post-smolts. Using generalized additive mixed-effects modelling, we analysed spatio-temporal variations in the dates of downstream smolt migration in 67 rivers throughout the North Atlantic during the last five decades and found that migrations were earlier in populations in the east than the west. After accounting for this spatial effect, the initiation of the downstream migration among rivers was positively associated with freshwater temperatures, up to about 10 °C and levelling off at higher values, and with sea-surface temperatures. Earlier migration occurred when river discharge levels were low but increasing. On average, the initiation of the smolt seaward migration has occurred 2.5 days earlier per decade throughout the basin of the North Atlantic. This shift in phenology matches changes in air, river, and ocean temperatures, suggesting that Atlantic salmon emigration is responding to the current global climate changes.
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