| 1. |
- Cacciani, P, et al.
(författare)
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Lifetime measurements of the E (1)Pi, upsilon=0 and upsilon=1 states of (CO)-C-12-O-16, (CO)-C-13-O-16, and (CO)-C-13-O-18
- 1998
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Ingår i: Astrophysical Journal. - : American Astronomical Society. - 0004-637X. ; 499
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Tidskriftsartikel (refereegranskat)abstract
- In a laboratory investigation using tunable picosecond lasers in a pump-probe configuration, lifetimes of the E (II)-I-1, v = O and v = 1 states of CO are experimentally determined. For E (II)-I-1, v = 1, the lifetime is found to vary significantly for the isotopomers. Combining the data with existing oscillator strengths, predissociation probabilities within the range of 93.6%-98.64% result for (CO)-C-12-O-16, (CO)-C-13-O-16, and (CO)-C-13-O-18 in, the case of the E (II)-I-1, v=1 state, which is the state that predominantly influences the isotopic fractionation of CO in interstellar clouds.
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| 2. |
- Cacciani, P., et al.
(författare)
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Lifetime measurements of the e1II, v = 0 and v = 1 states of12C16O, 13C16O, and13C18O
- 1998
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Ingår i: Astrophysical Journal. - 0004-637X. ; 499:2 PART II, s. 223-226
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Tidskriftsartikel (refereegranskat)abstract
- In a laboratory investigation using tunable picosecond lasers in a pump-probe configuration, lifetimes of the E 1u, v = 0 and v = 1 states of CO are experimentally determined. For E 'D, v = 1, the lifetime is found to vary significantly for the isotopomers. Combining the data with existing oscillator strengths, predissociation probabilities within the range of 93.6%-98.6% result for 12C16O, 13C16O, and 13C18O in the case of the E 1u, v = I state, which is the state that predominantly influences the isotopic fractionation of CO in interstellar clouds.
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| 3. |
- Cacciani, Nicola, et al.
(författare)
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Chaperone co-inducer BGP-15 mitigates early contractile dysfunction of the soleus muscle in a rat ICU model
- 2020
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Ingår i: Acta Physiologica. - : Wiley. - 1748-1708 .- 1748-1716. ; 229:1
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Tidskriftsartikel (refereegranskat)abstract
- Aim Critical illness myopathy (CIM) represents a common consequence of modern intensive care, negatively impacting patient health and significantly increasing health care costs; however, there is no treatment available apart from symptomatic and supportive interventions. The chaperone co-inducer BGP-15 has previously been shown to have a positive effect on the diaphragm in rats exposed to the intensive care unit (ICU) condition. In this study, we aim to explore the effects of BGP-15 on a limb muscle (soleus muscle) in response to the ICU condition. Methods Sprague-Dawley rats were subjected to the ICU condition for 5, 8 and 10 days and compared with untreated sham-operated controls. Results BGP-15 significantly improved soleus muscle fibre force after 5 days exposure to the ICU condition. This improvement was associated with the protection of myosin from post-translational myosin modifications, improved mitochondrial structure/biogenesis and reduced the expression of MuRF1 and Fbxo31 E3 ligases. At longer durations (8 and 10 days), BGP-15 had no protective effect when the hallmark of CIM had become manifest, that is, preferential loss of myosin. Unrelated to the effects on skeletal muscle, BGP-15 had a strong positive effect on survival compared with untreated animals. Conclusions BGP-15 treatment improved soleus muscle fibre and motor protein function after 5 days exposure to the ICU condition, but not at longer durations (8 and 10 days) when the preferential loss of myosin was manifest. Thus, long-term CIM interventions targeting limb muscle fibre/myosin force generation capacity need to consider both the post-translational modifications and the loss of myosin.
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| 4. |
- Cacciani, P, et al.
(författare)
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Isotope dependent predissociation in the C-1 Sigma(+) ,v=0 and v=1 states of CO
- 2001
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Ingår i: European Physical Journal D. Atomic, Molecular, Optical and Plasma Physics. - : Springer Science and Business Media LLC. - 1434-6060. ; 15:1, s. 47-56
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Tidskriftsartikel (refereegranskat)abstract
- Rotationally resolved spectral lines in the C-X(1,0) band of carbon monoxide are investigated under high resolution using a coherent vacuum ultraviolet laser source, continuously tunable near 107 nm. Transition frequencies are determined by calibrating against a reference standard of iodine lines, recorded with saturation spectroscopy in the visible range, yielding an absolute accuracy of 0.003 cm(-1) in the vacuum ultraviolet. Improved molecular constants for the excited state are clarified and Mo effects of perturbation are found at the present level of accuracy. Line broadening measurements result in information on the excited state lifetime of the (CC)-C-1 Sigma (+),v = 1 state fur five natural isotopomers: of cal bon monoxide: tau((CO)-C-12-O-17) = 280 ps, tau((CO)-C-12-O-18) = 210 ps. tau((CO)-C-13-O-16) = 295 ps, tau((OO)-O-13-O-17) = 160 ps and tau((CO)-C-13-O-18) = 150 Ps. Within the accuracy of the present measurements: Ilo effects: of J-dependent lifetimes: were observed, for neither of the isotopomers. In addition direct time domain measurements: of the lifetime of the C(1)Sigma (+),v = 0 and v = 1 states of the main isotopomer are performed ill a pump-mode experiment using a picosecond VUV-laser, yielding tau((CO)-C-12-O-16) = 1780 ps for v = 0 and tau((CC)-C-12-C-16)) = 625 ps for v = 1. For C(1)Sigma (+), v = 0 in (CO)-C-12-O-16 and (CO)-C-13-O-16 the same lifetime is found; this lifetime matches experimental values of the oscillator strength and hence supports previous results showing pure radiative decay ill this state; the error margins however do not exclude some low level of predissociation. The measurements indicate that the C(1)Sigma (+),v = 0 state of the (CO)-C-13-O-18 isotopomer is predissociated with an estimated yield of 17% (i.e. above the level of predissociation for (CO)-C-12-O-16.) From the combined data predissociation yields: upon excitation of the C(1)Sigma (+),v = 1 state are derived, lying in the range 0.84-0.91. for the five less abundant isotopomers; for the main (CO)-C-12-O-16 isotopomer a strongly deviating predissociation yield of 0.65 is deduced.
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| 5. |
- Cacciani, P, et al.
(författare)
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Predissociation of the 4p pi L-1 Pi Rydberg state of carbon monoxide
- 2002
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Ingår i: Chemical Physics. - 0301-0104. ; 282:1, s. 63-73
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Tidskriftsartikel (refereegranskat)abstract
- Time-domain and frequency-domain spectroscopic experiments have been performed on the (4ppi)L(1)Pi, v = 0 Rydberg state in three isotopomers of carbon monoxide. Accurate values for the excited state lifetimes of the f-parity components have been determined: tau((CO)-C-12-O-16) = 1.08 +/- 0.05 ns, tau((CO)-C-13-O-16) = 72 +/- 10 ps and tau((CO)-C-13-O-18) = 29 +/- 6 ps. The spectral resolution in the frequency-domain experiment goes as far as the limit imposed by the natural lifetime; Q-branch lines, or f-parity components of the heavier isotopes, are resolved for the first time. Highly accurate transition frequencies are determined in a molecular beam experiment using comparison and interpolation with a saturated iodine reference standard. The results reveal a number of perturbations and predissociation mechanisms, displaying a high degree of complexity in the energetic region of the 4p Rydberg states of CO with strong isotopic effects. (C) 2002 Elsevier Science B.V. All rights reserved.
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| 6. |
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