| 1. |
- Appeltans, W., et al.
(författare)
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The Magnitude of Global Marine Species Diversity
- 2012
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Ingår i: Current Biology. - : Elsevier BV. - 0960-9822 .- 1879-0445. ; 22:23, s. 2189-2202
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Tidskriftsartikel (refereegranskat)abstract
- Background: The question of how many marine species exist is important because it provides a metric for how much we do and do not know about life in the oceans. We have compiled the first register of the marine species of the world and used this baseline to estimate how many more species, partitioned among all major eukaryotic groups, may be discovered. Results: There are similar to 226,000 eukaryotic marine species described. More species were described in the past decade (similar to 20,000) than in any previous one. The number of authors describing new species has been increasing at a faster rate than the number of new species described in the past six decades. We report that there are similar to 170,000 synonyms, that 58,000-72,000 species are collected but not yet described, and that 482,000-741,000 more species have yet to be sampled. Molecular methods may add tens of thousands of cryptic species. Thus, there may be 0.7-1.0 million marine species. Past rates of description of new species indicate there may be 0.5 +/- 0.2 million marine species. On average 37% (median 31%) of species in over 100 recent field studies around the world might be new to science. Conclusions: Currently, between one-third and two-thirds of marine species may be undescribed, and previous estimates of there being well over one million marine species appear highly unlikely. More species than ever before are being described annually by an increasing number of authors. If the current trend continues, most species will be discovered this century.
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| 2. |
- Ferrari, Raffaele, et al.
(författare)
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Frontotemporal dementia and its subtypes: a genome-wide association study.
- 2014
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Ingår i: Lancet Neurology. - 1474-4465. ; 13:7, s. 686-699
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Tidskriftsartikel (refereegranskat)abstract
- Frontotemporal dementia (FTD) is a complex disorder characterised by a broad range of clinical manifestations, differential pathological signatures, and genetic variability. Mutations in three genes-MAPT, GRN, and C9orf72-have been associated with FTD. We sought to identify novel genetic risk loci associated with the disorder.
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| 3. |
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| 4. |
- Maurin, Hanna, et al.
(författare)
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Exploring gender differences in perceptions of 3D telepresence collaboration technology : An example from emergency medical care.
- 2006
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Ingår i: Proceedings of 4th Nordic Conference on Human-Computer Interaction. - : ACM Press. ; , s. 381-
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Konferensbidrag (refereegranskat)abstract
- Previous research on gender differences and collaboration technology illustrate the need to investigate gender issues as early as possible in the development cycle in order to avoid any negative consequences the technology may impose. Therefore we are investigating the potential of 3D telepresence technology now when only a proof-of-concept demonstration of the technology exists. We conducted a controlled lab study using a post-test design in which male and female paramedics diagnosed and treated a trauma victim (a computerized mannequin) in collaboration with a physician via 2D video or a 3D proxy. The results show several gender differences that imply male paramedics may inherently receive more benefits from use of the 3D telepresence technology than female paramedics.
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| 5. |
- Maurin Söderholm, Hanna, et al.
(författare)
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Exploring the potential of video technologies for collaboration in emergency medical care : Part II. Task performance
- 2008
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Ingår i: Journal of The American Society For Information Science And Technology. - : John Wiley & Sons, Inc.. - 1532-2882 .- 1532-2890. ; 59:14, s. 2335-2349
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Tidskriftsartikel (refereegranskat)abstract
- We conducted an experiment with a posttest, between-subjects design to evaluate the potential of emerging 3D telepresence technology to support collaboration in emergency health care. 3D telepresence technology has the potential to provide richer visual information than do current 2D video conferencing techniques. This may be of benefit in diagnosing and treating patients in emergency situations where specialized medical expertise is not locally available. The experimental design and results concerning information behavior are presented in the article “Exploring the Potential of Video Technologies for Collaboration in Emergency Medical Care: Part I. Information Sharing” (Sonnenwald et al., this issue). In this article, we explore paramedics' task performance during the experiment as they diagnosed and treated a trauma victim while working alone or in collaboration with a physician via 2D videoconferencing or via a 3D proxy. Analysis of paramedics' task performance shows that paramedics working with a physician via a 3D proxy performed the fewest harmful interventions and showed the least variation in task performance time. Paramedics in the 3D proxy condition also reported the highest levels of self-efficacy. Interview data confirm these statistical results. Overall, the results indicate that 3D telepresence technology has the potential to improve paramedics' performance of complex medical tasks and improve emergency trauma health care if designed and implemented appropriately.
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| 6. |
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| 7. |
- Sonnenwald, Diane H., et al.
(författare)
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Experimental comparison of 2D and 3D technology mediated paramedic-physician collaboration in remote emergency medical situations
- 2006
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Ingår i: Proceedings of the 69th Annual Meeting of the American Society of Information Science & Technoligy (ASIS&T). - : American Society for Information Science and Technology.
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Konferensbidrag (refereegranskat)abstract
- We are investigating the potential of 3D telepresence technology to support collaboration among geographically separated medical personnel in trauma emergency care situations. 3D telepresence technology has the potential to provide richer visual information than current 2D video conferencing techniques. This may be of benefit in diagnosing and treating patients in emergency situations where specialized medical expertise is not locally available. We conducted an experimental evaluation, simulating an emergency medical situation and examining the interaction between the attending paramedic and remote, consulting physician. Post-questionnaire data illustrate that the information provided by the consulting physician was perceived to be more useful by the paramedic in the 3D condition than the 2D condition. However, the data pertaining to the quality of interaction and trust between the consulting physician and paramedic showed mixed results. The implications of these results are discussed.
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| 8. |
- Sonnenwald, Diane H., et al.
(författare)
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Exploring the potential of video technologies for collaboration in emergency medical care : Part I. Information sharing
- 2008
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Ingår i: Journal of The American Society For Information Science And Technology. - : John Wiley & Sons, Inc.. - 1532-2882 .- 1532-2890. ; 59:14, s. 2320-2334
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Tidskriftsartikel (refereegranskat)abstract
- We are investigating the potential of 3D telepresence, or televideo, technology to support collaboration among geographically separated medical personnel in trauma emergency care situations. 3D telepresence technology has the potential to provide richer visual information than current 2D videoconferencing techniques. This may be of benefit in diagnosing and treating patients in emergency situations where specialized medical expertise is not locally available. The 3D telepresence technology does not yet exist, and there is a need to understand its potential before resources are spent on its development and deployment. This poses a complex challenge. How can we evaluate the potential impact of a technology within complex, dynamic work contexts when the technology does not yet exist? To address this challenge, we conducted an experiment with a posttest, between-subjects design that takes the medical situation and context into account. In the experiment, we simulated an emergency medical situation involving practicing paramedics and physicians, collaborating remotely via two conditions: with today's 2D videoconferencing and a 3D telepresence proxy. In this article, we examine information sharing between the attending paramedic and collaborating physician. Postquestionnaire data illustrate that the information provided by the physician was perceived to be more useful by the paramedic in the 3D proxy condition than in the 2D condition; however, data pertaining to the quality of interaction and trust between the collaborating physician and paramedic show mixed results. Postinterview data help explain these results.
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| 9. |
- Van Deerlin, Vivian M, et al.
(författare)
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Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions
- 2010
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Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 42:3, s. 234-239
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Tidskriftsartikel (refereegranskat)abstract
- Frontotemporal lobar degeneration (FTLD) is the second most common cause of presenile dementia. The predominant neuropathology is FTLD with TAR DNA-binding protein (TDP-43) inclusions (FTLD-TDP). FTLD-TDP is frequently familial, resulting from mutations in GRN (which encodes progranulin). We assembled an international collaboration to identify susceptibility loci for FTLD-TDP through a genome-wide association study of 515 individuals with FTLD-TDP. We found that FTLD-TDP associates with multiple SNPs mapping to a single linkage disequilibrium block on 7p21 that contains TMEM106B. Three SNPs retained genome-wide significance following Bonferroni correction (top SNP rs1990622, P = 1.08 x 10(-11); odds ratio, minor allele (C) 0.61, 95% CI 0.53-0.71). The association replicated in 89 FTLD-TDP cases (rs1990622; P = 2 x 10(-4)). TMEM106B variants may confer risk of FTLD-TDP by increasing TMEM106B expression. TMEM106B variants also contribute to genetic risk for FTLD-TDP in individuals with mutations in GRN. Our data implicate variants in TMEM106B as a strong risk factor for FTLD-TDP, suggesting an underlying pathogenic mechanism.
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| 10. |
- Wang, Li-San, et al.
(författare)
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Rarity of the Alzheimer Disease-Protective APP A673T Variant in the United States.
- 2015
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Ingår i: JAMA neurology. - : American Medical Association (AMA). - 2168-6157 .- 2168-6149. ; 72:2
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Tidskriftsartikel (refereegranskat)abstract
- Recently, a rare variant in the amyloid precursor protein gene (APP) was described in a population from Iceland. This variant, in which alanine is replaced by threonine at position 673 (A673T), appears to protect against late-onset Alzheimer disease (AD). We evaluated the frequency of this variant in AD cases and cognitively normal controls to determine whether this variant will significantly contribute to risk assessment in individuals in the United States.
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