| 1. |
- Pantazis, N, et al.
(författare)
-
Determining the likely place of HIV acquisition for migrants in Europe combining subject-specific information and biomarkers data
- 2019
-
Ingår i: Statistical methods in medical research. - : SAGE Publications. - 1477-0334 .- 0962-2802. ; 28:7, s. 1979-1997
-
Tidskriftsartikel (refereegranskat)abstract
- In most HIV-positive individuals, infection time is only known to lie between the time an individual started being at risk for HIV and diagnosis time. However, a more accurate estimate of infection time is very important in certain cases. For example, one of the objectives of the Advancing Migrant Access to Health Services in Europe (aMASE) study was to determine if HIV-positive migrants, diagnosed in Europe, were infected pre- or post-migration. We propose a method to derive subject-specific estimates of unknown infection times using information from HIV biomarkers’ measurements, demographic, clinical, and behavioral data. We assume that CD4 cell count (CD4) and HIV-RNA viral load trends after HIV infection follow a bivariate linear mixed model. Using post-diagnosis CD4 and viral load measurements and applying the Bayes’ rule, we derived the posterior distribution of the HIV infection time, whereas the prior distribution was informed by AIDS status at diagnosis and behavioral data. Parameters of the CD4–viral load and time-to-AIDS models were estimated using data from a large study of individuals with known HIV infection times (CASCADE). Simulations showed substantial predictive ability (e.g. 84% of the infections were correctly classified as pre- or post-migration). Application to the aMASE study ( n = 2009) showed that 47% of African migrants and 67% to 72% of migrants from other regions were most likely infected post-migration. Applying a Bayesian method based on bivariate modeling of CD4 and viral load, and subject-specific information, we found that the majority of HIV-positive migrants in aMASE were most likely infected after their migration to Europe.
|
|
| 2. |
|
|
| 3. |
- Fantini, R, et al.
(författare)
-
EU FP7 INFSO-ICT-317669 METIS, D3.2 First performance results for multi-node/multi-antenna transmission technologies
- 2014
-
Rapport (övrigt vetenskapligt/konstnärligt)abstract
- This deliverable describes the current results of the multi-node/multi-antenna technologies investigated within METIS and analyses the interactions within and outside Work Package 3. Furthermore, it identifies the most promising technologies based on the current state of obtained results. This document provides a brief overview of the results in its first part. The second part, namely the Appendix, further details the results, describes the simulation alignment efforts conducted in the Work Package and the interaction of the Test Cases. The results described here show that the investigations conducted in Work Package 3 are maturing resulting in valuable innovative solutions for future 5G systems.
|
|
| 4. |
|
|
| 5. |
|
|
| 6. |
- Ribeiro, Tânia M., et al.
(författare)
-
CARINA : A near-Earth D-type asteroid sample return mission
- 2023
-
Ingår i: Acta Astronautica. - : Elsevier. - 0094-5765 .- 1879-2030. ; 212, s. 213-225
-
Tidskriftsartikel (refereegranskat)abstract
- D-type asteroids are among the most primitive small bodies of the solar system. Believed to be formed in the outer solar system, a minor fraction of these faint objects can be found in the near-Earth region. Some were suspected to be extinct comets disguised as asteroids. If D-type near-Earth asteroids could represent extinct comets, they would offer us a unique opportunity to investigate the relationship between two classes of minor bodies in our solar system. To provide new insights into D-type asteroids' composition and dynamical evolution and the possible relation with comets, we introduce the mission concept CARINA (Comet Asteroid Relation INvestigation and Analysis). CARINA will visit and collect a sample from the asteroid 2002 AT4 and address key scientific questions related to our understanding of the early solar system evolution, and the origins of water and life on the early Earth. This paper outlines the scientific motivation and the means for the sample return. The spacecraft is equipped with a sampling ring to perform in-situ analysis and to collect, in a "touch and go"manner, samples from the surface and subsurface of the asteroid. A capsule is expected to return the samples to Earth in pristine conditions for detailed and extended analysis. These would represent a rare contribution to our meteorite collection since it would be the first time that material from a D class asteroid would be collected.
|
|
