| 1. |
- Svensson, Börje, et al.
(författare)
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Hela vårdkedjan i fokus : Forskningen på käkkirurgiska kliniken spänner från planering till rehabilitering
- 2009
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Ingår i: Tandläkartidningen. - Stockholm : Sveriges tandläkarförbund. - 0039-6982. ; 101:4, s. 64-
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Tidskriftsartikel (populärvet., debatt m.m.)abstract
- På Käkkirurgiska kliniken vid Universitetssjukhuset i Örebro (USÖ) har vi inom den högspecialiserade vården utvecklat en flerårig och bred erfarenhet av framför allt käkrekonstruktioner och käkledskirurgi. Utöver den kirurgiska verksamheten är samarbete, både nationellt och internationellt, en viktig del av vår vardag.
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| 2. |
- Svensson, Börje, et al.
(författare)
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Patientnära forskning ett prioriterat område
- 2009
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Ingår i: Tandläkartidningen. - Stockholm : Sveriges tandläkarförbund. - 0039-6982. ; 101:4, s. 65-69
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Tidskriftsartikel (populärvet., debatt m.m.)abstract
- Käkkirurgiska forskningsenhetens pågående projekt består till stor del av klinisk patientnära forskning, vilket är ett av Örebro universitets prioriterade forskningsområden.
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| 3. |
- Afshari, Mariam, 1989-, et al.
(författare)
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Development of an oral health-related quality of life questionnaire on neurosensory disturbances after orthognathic surgery - a pilot study.
- 2022
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Ingår i: Acta odontologica Scandinavica. - : Informa UK Limited. - 1502-3850 .- 0001-6357. ; 80:8, s. 635-640
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Tidskriftsartikel (refereegranskat)abstract
- Development of a new questionnaire, Oral Health-Related Quality of Life - Neurosensory Disturbances after Orthognathic Surgery (OHRQL-NDO), designed to measure the effects of neurosensory disturbance (NSD) on patients' oral health-related quality of life (OHRQL) and to evaluate reliability and validity of this questionnaire.A questionnaire including 11 items was constructed. Thirty patients with NSD affecting the lower lip and/or chin following orthognathic surgery were included. Convergent validity was assessed by comparing OHRQL-NDO with OHIP-14 and two global questions. Test-retest reliability was assessed by asking the patients to complete OHRQL-NDO at two different occasions with an interval of two to threeweeks.The internal consistency, measured with Cronbach's alpha, was 0.84. The test-retest reliability, measured with ICC, was 0.89 (95% CI 0.77-0.95). The correlation between the mean sum score for the OHRQL-NDO and the mean sum score for the OHIP-14 was r=0.75, using Pearson correlation coefficient. The correlations between the mean total score for the OHRQL-NDO and the global questions 1 and 2 were r=0.74 and r=0.72, respectively.The current instrument OHRQL-NDO is a promising test, but needs further development to better capture the different aspects of OHRQL. Further tests of the questionnaire must follow in other samples to finalize the instrument.
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| 4. |
- Ahl, Magnus, et al.
(författare)
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Translation and validation of the English-language instrument Orthognathic Quality of Life Questionair into Swedish
- 2021
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Ingår i: Acta Odontologica Scandinavica. - : Informa UK Limited. - 0001-6357 .- 1502-3850. ; 79:1, s. 19-24
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Tidskriftsartikel (refereegranskat)abstract
- Introduction: In orthognathic surgery, understanding the patient’s motives for treatment is a key factor for postoperative patient satisfaction and treatment success. In countries/systems where orthognathic surgery is funded by public means, patients are referred mainly due to functional problems, although studies of quality of life related changes after treatment indicate that psychosocial and aesthetic reasons might be equal or more important for the patient. There is no available validated condition specific instruments in the Swedish language for quality of life evaluation of patients with dentofacial deformities. Aims/objectives: Cross cultural translation and adaptation of the English-language instrument ‘Orthognathic Quality of Life Questionnaire’ (OQLQ) into Swedish. Methods: OQLQ was translated into Swedish. A total of 121 patients in four groups were recruited and the Swedish version of the OQLQ (OQLQ-S) was tested by psychometric methods. Reliability was assessed by internal consistency and test–retest reliability. Validity was evaluated by face, convergent and discriminant validity. Results/findings and conclusions: OQLQ-S is reliable and showed good construct validity and internal consistency and can be used in a Swedish speaking population as a complement to clinical variables to evaluate patients with dentofacial deformity. © 2020, © 2020 Acta Odontologica Scandinavica Society.
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| 5. |
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| 6. |
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| 7. |
- Cardemil, Carina
(författare)
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Effects of antiresorptive agents on inflammation and bone regeneration in different osseous sites - experimental and clinical studies
- 2014
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The biological mechanisms involved in bone regeneration in osteoporotic bone and the effect of antiresorptive drugs in relation to surgically inserted biomaterials are not fully understood. Improved osseointegration of titanium implants but also adverse effects of antiresorptive therapies, such as osteonecrotic jaw have been described in the literature. The aims of this research project were, firstly, to investigate and to understand the biological events determining bone regeneration and implant integration, after administration of antiresorptive agents; secondly, to determine the cellular and molecular patterns of bone regeneration at implants and synthetic bone substitutes under osteoporotic conditions and, thirdly, to determine how different skeletal sites are affected. The present research included a study of jawbone morphology and gene expression in patients treated with systemic bisphosphonates. When compared to controls, higher gene expression levels of IL-1β was observed in bisphosphonate treated patients with osteonecrosis while bisphosphonate treated patients without necrosis showed lower expression levels of caspase 8, an apoptosis marker involved in the immune response. In ovariectomised rats, zoledronic acid resulted in site-specific differences in the rate of osseointegration and also of gene expression involved in bone healing and regeneration. Strontium-doped calcium phosphate inserted in the rat femur induced lower expression of osteoclastic markers compared to hydroxyapatite and higher bone formation in the periphery of the defects. Whereas major structural changes were demonstrated in the long bones of the ovariectomised rat, less structural alterations were shown in the mandible. However, ovariectomy resulted in lower expression of genes coding for bone formation and angiogenesis in the mandible. In conclusion, the present study shows that the mandible is differently affected by experimentally induced estrogen deficiency than the long bones. Bisphosphonates, administered systemically to estrogen deficient animals, impair osseointegration in the mandible, at least partly related to a downregulation of genes important for the osteogenic process. These observations may have implications for understanding the mechanisms involved in the deranged bone healing observed in the jawbone of bisphosphonate treated patients.
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| 8. |
- Cardemil, Carina, et al.
(författare)
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Influence of different operatory setups on implant survival rate: a retrospective clinical study
- 2009
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Ingår i: Clinical Implant Dentistry and Related Research. - : John Wiley & Sons. - 1708-8208 .- 1523-0899. ; 11:4, s. 288-291
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Tidskriftsartikel (refereegranskat)abstract
- Abstract BACKGROUND: Surgery performed under sterile operating conditions, as well as atraumatic surgery, has been stated to be among the most important requirements for successful osseointegration. However, there are few reports concerning the sterile surgical technique in association with implant placement, and the appropriate level of operatory setup is not fully known. PURPOSE: The purpose of this study was to analyze implant survival rate using a simplified surgical operatory setup compared with the use of the original Brånemark System (Nobel Biocare AB, Göteborg, Sweden) protocol. MATERIALS AND METHODS: A total of 1,285 consecutively treated patients were included in the study. Four thousand implants were placed during the period of 1985 to 2003. Group A (using the Brånemark System protocol) comprised of 654 patients and 2,414 implants. Group B (using a simplified operatory setup) comprised of 631 patients and 1,586 implants. Healing was evaluated after 6 months of clinical function. Failure was defined as the removal of implants because of nonosseointegration. Statistic analysis was performed using t-test for paired data. The level of significance was set at 5% for comparison of data. RESULTS: No significant difference with regard to complications and implant survival rate was found in the study. CONCLUSION: The result from the present study suggests that a simplified operatory setup does not affect the survival rate of oral implant treatment.
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| 9. |
- Cardemil, Carina, et al.
(författare)
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Jaw Bone Samples From Bisphosphonate-Treated Patients : A Pilot Cohort Study
- 2015
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Ingår i: Clinical Implant Dentistry and Related Research. - : Wiley-Blackwell. - 1523-0899 .- 1708-8208. ; 17, s. E679-E691
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Tidskriftsartikel (refereegranskat)abstract
- Osteonecrosis of the jaw (ONJ) is a severe complication of bisphosphonate treatment. PurposeA detailed characterization of sampled peri-necrotic jawbone from bisphosphonate-treated patients was performed at tissue and cellular level (histological analyses and gene expression). Materials and MethodsAlveolar bone samples were collected from patients with (n=5) and without ONJ (n=5). Healthy patients served as controls (n=10). ResultsThe histological analysis demonstrated low to moderate inflammation, displaying areas of inflammatory infiltrate in the bone marrow. Multinuclear giant cells and osteoclasts were found in both groups. Markers of bone formation (alkaline phosphatase, Col1a1, and osteocalcin), bone resorption (receptor activator of NF-kappaB ligand [RANKL], osteoprotegerin [OPG], tartrate-resistant acid phosphatase, and cathepsin K), inflammation (tumor necrosis factor-alpha, interleukin [IL]-1, and IL-6), angiogenesis (vascular endothelial growth factor A), and apoptosis (Casp3, Casp8, p53, and Smac) were evaluated. Nonparametric statistical tests were used to identify differences between the groups. In patients with ONJ, the expression level of the proinflammatory marker IL-1 was strongly up-regulated compared with controls (p=.040). ConclusionsA down-regulated expression of Casp8 compared with controls was observed (p=.014) in patients treated with bisphosphonates. The RANKL/OPG ratios were similar in the three groups. The results indicate a need to further investigate the molecular mechanisms involved in the course of ONJ related to antiresorptive treatment.
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| 10. |
- Cardemil, Carina, et al.
(författare)
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Strontium-doped calcium phosphate and hydroxyapatite granules promote different inflammatory and bone remodelling responses in normal and ovariectomised rats.
- 2013
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Ingår i: PLosOne. - : Public Library of Science (PLoS). - 1932-6203. ; 8:12
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Tidskriftsartikel (refereegranskat)abstract
- The healing of bone defects may be hindered by systemic conditions such as osteoporosis. Calcium phosphates, with or without ion substitutions, may provide advantages for bone augmentation. However, the mechanism of bone formation with these materials is unclear. The aim of this study was to evaluate the healing process in bone defects implanted with hydroxyapatite (HA) or strontium-doped calcium phosphate (SCP) granules, in non-ovariectomised (non-OVX) and ovariectomised (OVX) rats. After 0 (baseline), six and 28d, bone samples were harvested for gene expression analysis, histology and histomorphometry. Tumour necrosis factor-α (TNF-α), at six days, was higher in the HA, in non-OVX and OVX, whereas interleukin-6 (IL-6), at six and 28d, was higher in SCP, but only in non-OVX. Both materials produced a similar expression of the receptor activator of nuclear factor kappa-B ligand (RANKL). Higher expression of osteoclastic markers, calcitonin receptor (CR) and cathepsin K (CatK), were detected in the HA group, irrespective of non-OVX or OVX. The overall bone formation was comparable between HA and SCP, but with topological differences. The bone area was higher in the defect centre of the HA group, mainly in the OVX, and in the defect periphery of the SCP group, in both non-OVX and OVX. It is concluded that HA and SCP granules result in comparable bone formation in trabecular bone defects. As judged by gene expression and histological analyses, the two materials induced different inflammatory and bone remodelling responses. The modulatory effects are associated with differences in the spatial distribution of the newly formed bone.
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