| 1. |
- Balboa, Diego, et al.
(författare)
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Functional, metabolic and transcriptional maturation of human pancreatic islets derived from stem cells.
- 2022
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Ingår i: Nature Biotechnology. - : Springer Nature. - 1087-0156 .- 1546-1696. ; 40:7, s. 1042-1055
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Tidskriftsartikel (refereegranskat)abstract
- Transplantation of pancreatic islet cells derived from human pluripotent stem cells is a promising treatment for diabetes. Despite progress in the generation of stem-cell-derived islets (SC-islets), no detailed characterization of their functional properties has been conducted. Here, we generated functionally mature SC-islets using an optimized protocol and benchmarked them comprehensively against primary adult islets. Biphasic glucose-stimulated insulin secretion developed during in vitro maturation, associated with cytoarchitectural reorganization and the increasing presence of alpha cells. Electrophysiology, signaling and exocytosis of SC-islets were similar to those of adult islets. Glucose-responsive insulin secretion was achieved despite differences in glycolytic and mitochondrial glucose metabolism. Single-cell transcriptomics of SC-islets in vitro and throughout 6 months of engraftment in mice revealed a continuous maturation trajectory culminating in a transcriptional landscape closely resembling that of primary islets. Our thorough evaluation of SC-islet maturation highlights their advanced degree of functionality and supports their use in further efforts to understand and combat diabetes.
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| 2. |
- Carlsson, Anni, 1988-
(författare)
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Constitutional Protection of Freedom of Expression in the Age of Social Media : A Comparative Study
- 2024
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Social media platforms are increasingly important arenas for communication in today’s society. These platforms can both enable and restrict their users’ exercise of free speech. The right to freedom of expression has traditionally protected individuals against state interference. However, the most popular social media platforms are owned by private companies, which creates new challenges for the constitutional protection of freedom of expression. This study examines how constitutional free speech rights have been adapted and should be adapted to the new communicative landscape dominated by social media.A comparative study of the adaption of constitutional free speech guarantees to social media in the US, Sweden and Germany is carried out. Relevant European law (European Convention on Human Rights and European Union law) is also included in the comparison. Four dimensions of the exercise of free speech on social media are compared. Firstly, social media users' and platforms' free speech rights are studied. Secondly, it is analysed whether constitutional free speech rights can be applied to relationships between private social media platforms and their users (horizontal effect). Thirdly, the state’s potential positive obligations to protect users' freedom of expression against social media companies are examined. Finally, laws regulating the effects of social media platforms on free speech exercise are addressed, including the Digital Services Act adopted by the European Union.Through the comparative analysis, different constitutional law mechanisms that allow freedom of expression to impact relationships between private social media platforms and their users are identified. Constitutional free speech guarantees can affect the activities of social media platforms through the horizontal effect of constitutional rights or the state’s positive obligations. Even without horizontal effect and positive obligations, the constitutional free speech law may allow the state to regulate platforms’ power over free speech through ordinary laws. It is argued that regardless of which of these constitutional law mechanisms is used, it is necessary to balance competing free speech interests of speakers, audience, platforms and society against each other. Guidelines for weighing the various free speech interests against each other are presented in the last chapter of the dissertation. It is suggested, among other things, that democracy should be chosen as the guiding free speech value for such a balancing exercise.
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| 7. |
- Carlsson, Anni, et al.
(författare)
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Sweden
- 2021
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Ingår i: I·CONnect-Clough Center 2020 Global Review of Constitutional Law. - : Clough Center for the Study of Constitutional Democracy. - 9780692159163 ; , s. 289-292
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 8. |
- Carlsson, Anni
(författare)
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Sweden
- 2022
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Ingår i: The 2021 Global Review of Constitutional Law. - : EUT Edizioni Università di Trieste. - 9788855113618 - 9780692159163 ; , s. 332-336
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 9. |
- Carlsson, Anni
(författare)
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Sweden
- 2023
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Ingår i: 2022 Global Review of Constitutional Law. - Trieste : EUT Edizioni Università di Trieste. - 9781737452751 - 9788855114608 ; , s. 324-328
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 10. |
- Carlsson, Anni
(författare)
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Tyst vår? : När Twitter och Facebook tystade en presidents kvitter och vad det innebär för yttrandefrihet på sociala medier
- 2021
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Ingår i: Svensk Juristtidning. - : Föreningen för utgivande av Svensk Juristtidning. - 0039-6591. ; , s. 169-178
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Avstängningen av USA:s f.d. president Donald Trump från Twitter och flera andra sociala medieplattformar har väckt debatt kring privata företags ansvar för yttrandefrihet och demokrati. Trumps bannlysning ger upphov till flera komplexa juridiska frågor och understryker behovet av att analysera de sociala medieföretagens agerande och rättsliga ställning från ett helhetsperspektiv.
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