| 1. |
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| 2. |
- Svanberg, Sune, et al.
(författare)
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Applications of terawatt lasers
- 1994
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Ingår i: LASER SPECTROSCOPY - XITH INTERNATIONAL CONFERENCE. - : AIP. - 1551-7616 .- 0094-243X. - 1563962624 ; :290, s. 264-269
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Konferensbidrag (refereegranskat)
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| 3. |
- Forsberg, Ulrika, et al.
(författare)
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Spectroscopic Tools Applied to Element Z = 115 Decay Chains
- 2014
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Ingår i: EPJ Web of Conferences. - : EDP Sciences. - 2100-014X .- 2101-6275. - 9782759811755 - 9782759811762 ; 66, s. 02036-02036
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Konferensbidrag (refereegranskat)abstract
- Nuclides that are considered to be isotopes of element Z = 115 were produced in the reaction 48Ca + 243Am at the GSI Helmholtzzentrum für Schwerionenforschung Darmstadt. The detector setup TASISpec was used. It was mounted behind the gas-filled separator TASCA. Thirty correlated α-decay chains were found, and the energies of the particles were determined with high precision. Two important spectroscopic aspects of the offline data analysis are discussed in detail: the handling of digitized preamplified signals from the silicon strip detectors, and the energy reconstruction of particles escaping to upstream detectors relying on pixel-by-pixel dead-layer thicknesses.
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| 4. |
- Lystad, Aif Hakon, et al.
(författare)
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Distinct functions of ATG16L1 isoforms in membrane binding and LC3B lipidation in autophagy-related processes
- 2019
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Ingår i: Nature Cell Biology. - : NATURE PUBLISHING GROUP. - 1465-7392 .- 1476-4679. ; 21:3, s. 372-383
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Tidskriftsartikel (refereegranskat)abstract
- Covalent modification of LC3 and GABARAP proteins to phosphatidylethanolamine in the double-membrane phagophore is a key event in the early phase of macroautophagy, but can also occur on single-membrane structures. In both cases this involves transfer of LC3/GABARAP from ATG3 to phosphatidylethanolamine at the target membrane. Here we have purified the full-length human ATG12-5-ATG16L1 complex and show its essential role in LC3B/GABARAP lipidation in vitro. We have identified two functionally distinct membrane-binding regions in ATG16L1. An N-terminal membrane-binding amphipathic helix is required for LC3B lipidation under all conditions tested. By contrast, the C-terminal membrane-binding region is dispensable for canonical autophagy but essential for VPS34-independent LC3B lipidation at perturbed endosomes. We further show that the ATG16L1 C-terminus can compensate for WIPI2 depletion to sustain lipidation during starvation. This C-terminal membrane-binding region is present only in the beta-isoform of ATG16L1, showing that ATG16L1 isoforms mechanistically distinguish between different LC3B lipidation mechanisms under different cellular conditions.
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| 5. |
- Såmark-Roth, Anton, et al.
(författare)
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Spectroscopy along flerovium decay chains: Discovery of 280Ds and an excited state in 282Cn
- 2021
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Ingår i: Physical Review Letters. - 1079-7114. ; 126:3
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Tidskriftsartikel (refereegranskat)abstract
- A nuclear spectroscopy experiment was conducted to study α-decay chains stemming from isotopes of flerovium (element Z=114). An upgraded TASISpec decay station was placed behind the gas-filled separator TASCA at the GSI Helmholtzzentrum für Schwerionenforschung in Darmstadt, Germany. The fusion-evaporation reactions 48Ca+242Pu and 48Ca+244Pu provided a total of 32 flerovium-candidate decay chains, of which two and eleven were firmly assigned to 286Fl and 288Fl, respectively. A prompt coincidence between a 9.60(1)-MeV α-particle event and a 0.36(1)-MeV conversion electron marked the first observation of an excited state in an even-even isotope of the heaviest man-made elements, namely 282Cn. Spectroscopy of 288Fl decay chains fixed Qα=10.06(1) MeV. In one case, a Qα=9.46(1)-MeV decay from 284Cn into 280Ds was observed, with 280Ds fissioning after only 518 μs. The impact of these findings, aggregated with existing data on decay chains of 286,288Fl, on the size of an anticipated shell gap at proton number Z=114 is discussed in light of predictions from two beyond-mean-field calculations, which take into account triaxial deformation.
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| 6. |
- van Weering, Jan R. T., et al.
(författare)
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Molecular basis for SNX-BAR-mediated assembly of distinct endosomal sorting tubules
- 2012
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Ingår i: EMBO Journal. - : Wiley. - 0261-4189 .- 1460-2075. ; 31:23, s. 4466-4480
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Tidskriftsartikel (refereegranskat)abstract
- Sorting nexins (SNXs) are regulators of endosomal sorting. For the SNX-BAR subgroup, a Bin/Amphiphysin/Rvs (BAR) domain is vital for formation/stabilization of tubular subdomains that mediate cargo recycling. Here, by analysing the in vitro membrane remodelling properties of all 12 human SNX-BARs, we report that some, but not all, can elicit the formation of tubules with diameters that resemble sorting tubules observed in cells. We reveal that SNX-BARs display a restricted pattern of BAR domain-mediated dimerization, and by resolving a 2.8 angstrom structure of a SNX1-BAR domain homodimer, establish that dimerization is achieved in part through neutralization of charged residues in the hydrophobic BAR-dimerization interface. Membrane remodelling also requires functional amphipathic helices, predicted to be present in all SNX-BARs, and the formation of high order SNX-BAR oligomers through selective 'tip-loop' interactions. Overall, the restricted and selective nature of these interactions provide a molecular explanation for how distinct SNX-BAR-decorated tubules are nucleated from the same endosomal vacuole, as observed in living cells. Our data provide insight into the molecular mechanism that generates and organizes the tubular endosomal network.
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| 7. |
- Abrahamsson, Kajsa H., 1956, et al.
(författare)
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Ambivalence in Coping with Dental Fear and Avoidance: A Qualitative Study
- 2002
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Ingår i: Journal of Health Psychology. - : SAGE Publications. - 1359-1053 .- 1461-7277. ; 7:6, s. 653-664
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Tidskriftsartikel (refereegranskat)abstract
- Dental phobia is a widespread problem, which can have significant impact on the individual's health and daily life. This grounded theory study aims to explore the situation of dental phobic patients: how dental phobia interferes with their normal routines and functioning, social activities and relationships, what factors contribute to the maintenance of dental fear and how they cope with their fear. In the qualitative analysis of thematized in-depth interviews four main categories were developed: threat to self-respect and well-being, avoidance, readiness to act and ambivalence in coping. The results show that several psychological and social factors interact in determining how dental phobic individuals cope with their fear, and demonstrate in what way dental fear affects their daily lives.
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| 8. |
- Abrahamsson, Kajsa H., 1956, et al.
(författare)
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Dental phobic patients' view of dental anxiety and experiences in dental care: a qualitative study.
- 2002
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Ingår i: Scandinavian journal of caring sciences. - 0283-9318. ; 16:2, s. 188-96
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Tidskriftsartikel (refereegranskat)abstract
- Dental phobic patients' view of dental anxiety and experiences in dental care: a qualitative study The aim of this study was to explore and describe dental phobic patients' perceptions of their dental fear and experiences in dental care. The study sample consisted of 18 participants (12 women), with a mean age of 39.4 years, selected consecutively from patients applying for treatment at a specialized dental fear clinic in G?teborg, Sweden. Dental fear, assessed by the Dental Anxiety Scale, showed score levels well over established levels for severe dental fear. The method for sampling and analysis was inspired by the constant comparative method for Grounded Theory (GT). The thematized in-depth interviews took place outside the clinic and lasted for 1-1.5 h. All the interviews were conducted by the first author (KHA), audiotaped and transcribed verbatim. Three higher-order categories were developed and labelled existential threat, vulnerability and unsupportive dentist. Existential threat was identified as the core category, describing the central meaning of the subjects' experiences in dental care. The core category included two dimensions, labelled threat of violation and threat of loss of autonomy and independence. The core category and the descriptive categories are integrated in a model framing the process of dental fear, as described by the informants. In conclusion, the onset of dental fear was commonly related to individual vulnerability and to traumatic dental care experiences, where perceived negative dentist behaviour played a significant role. The patient was caught in a 'vicious circle' that was difficult to break, and where fear and anxiety were maintained by negative expectations about treatment and about patient's own ability to cope in dental care situations.
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| 9. |
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| 10. |
- Björnsson, Ivar, et al.
(författare)
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Simulation of collision loads to bridge supporting structures from heavy goods vehicle traffic on Swedish highways
- 2013
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Ingår i: Safety, Reliability, Risk and Life-Cycle Performace of Structures & Infrastructures. - 9781138000865 ; , s. 2113-2120
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Konferensbidrag (refereegranskat)abstract
- This paper investigates accidental loading in the form of heavy goods vehicle (HGV) collisions to bridge supporting structures. Structures adjacent to roads are normally strong enough to resist collisions from light vehicles, while it may not be feasible for such structures to resist collisions from all HGVs (greater than 3,5 tons). In this paper a probabilistic model is used to determine these collision forces while Bridge Weigh In Motion (B-WIM) measurements performed on Swedish highways form the foundation for the calculated results. The probabilistic model is evaluated using Monte-Carlo simulations in which approximately 60 thousand B-WIM measurements are included. The results are compared with values given in the design codes and the implications of using codified prescriptive approaches in Eurocode 1-7 (CEN 2006) are discussed. It is found that the tabulated values given in the code are significantly lower than the values determined from the simulations. It can be questioned whether these loads are intended to provide adequate safety with respect to the intensity and weights of HGV vehicles in today’s traffic environment.
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