| 1. |
- Chu, Audrey Y, et al.
(författare)
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Multiethnic genome-wide meta-analysis of ectopic fat depots identifies loci associated with adipocyte development and differentiation
- 2017
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Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 49:1, s. 125-130
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Tidskriftsartikel (refereegranskat)abstract
- Variation in body fat distribution contributes to the metabolic sequelae of obesity. The genetic determinants of body fat distribution are poorly understood. The goal of this study was to gain new insights into the underlying genetics of body fat distribution by conducting sample-size-weighted fixed-effects genome-wide association meta-analyses in up to 9,594 women and 8,738 men of European, African, Hispanic and Chinese ancestry, with and without sex stratification, for six traits associated with ectopic fat (hereinafter referred to as ectopic-fat traits). In total, we identified seven new loci associated with ectopic-fat traits (ATXN1, UBE2E2, EBF1, RREB1, GSDMB, GRAMD3 and ENSA; P < 5 × 10(-8); false discovery rate < 1%). Functional analysis of these genes showed that loss of function of either Atxn1 or Ube2e2 in primary mouse adipose progenitor cells impaired adipocyte differentiation, suggesting physiological roles for ATXN1 and UBE2E2 in adipogenesis. Future studies are necessary to further explore the mechanisms by which these genes affect adipocyte biology and how their perturbations contribute to systemic metabolic disease.
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| 2. |
- Heslin, Alison, et al.
(författare)
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Simulating the Cascading Effects of an Extreme Agricultural Production Shock : Global Implications of a Contemporary US Dust Bowl Event
- 2020
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Ingår i: Frontiers in Sustainable Food Systems. - : Frontiers Media SA. - 2571-581X. ; 4
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Tidskriftsartikel (refereegranskat)abstract
- Higher temperatures expected by midcentury increase the risk of shocks to crop production, while the interconnected nature of the current global food system functions to spread the impact of localized production shocks throughout the world. In this study, we analyze the global potential impact of a present-day event of equivalent magnitude to the US Dust Bowl, modeling the ways in which a sudden decline in US wheat production could cascade through the global network of agricultural trade. We use observations of country-level production, reserves, and trade data in a Food Shock Cascade model to explore trade adjustments and country-level inventory changes in response to a major, multiyear production decline. We find that a 4-year decline in wheat production of the same proportional magnitude as occurred during the Dust Bowl greatly reduces both wheat supply and reserves in the United States and propagates through the global trade network. By year 4 of the event, US wheat exports fall from 90.5 trillion kcal before the drought to 48 trillion to 52 trillion kcal, and the United States exhausts 94% of its reserves. As a result of reduced US exports, other countries meet their needs by leveraging their own reserves, leading to a 31% decline in wheat reserves globally. These findings demonstrate that an extreme production decline would lead to substantial supply shortfalls in both the United States and in other countries, where impacts outside the United States strongly depend on a country's reserves and on its relative position in the global trade network.
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| 3. |
- Marchand, Philippe, et al.
(författare)
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Reserves and trade jointly determine exposure to food supply shocks
- 2016
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Ingår i: Environmental Research Letters. - : Institute of Physics Publishing (IOPP). - 1748-9326. ; 11:9
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Tidskriftsartikel (refereegranskat)abstract
- While a growing proportion of global food consumption is obtained through international trade, there is an ongoing debate on whether this increased reliance on trade benefits or hinders food security, and specifically, the ability of global food systems to absorb shocks due to local or regional losses of production. This paper introduces a model that simulates the short-term response to a food supply shock originating in a single country, which is partly absorbed through decreases in domestic reserves and consumption, and partly transmitted through the adjustment of trade flows. By applying the model to publicly-available data for the cereals commodity group over a 17 year period, we find that differential outcomes of supply shocks simulated through this time period are driven not only by the intensification of trade, but as importantly by changes in the distribution of reserves. Our analysis also identifies countries where trade dependency may accentuate the risk of food shortages from foreign production shocks; such risk could be reduced by increasing domestic reserves or importing food from a diversity of suppliers that possess their own reserves. This simulation-based model provides a framework to study the short-term, nonlinear and out-of-equilibrium response of trade networks to supply shocks, and could be applied to specific scenarios of environmental or economic perturbations.
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| 4. |
- Carr, Joel A., et al.
(författare)
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What commodities and countries impact inequality in the global food system?
- 2016
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Ingår i: Environmental Research Letters. - : IOP Publishing. - 1748-9326. ; 11:9
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Tidskriftsartikel (refereegranskat)abstract
- The global distribution of food production is unequal relative to the distribution of human populations. International trade can increase or decrease inequality in food availability, but little is known about how specific countries and commodities contribute to this redistribution. We present a method based on the Gini coefficient for evaluating the contributions of country and commodity specific trade to inequality in the global food system. We applied the method to global food production and trade data for the years 1986-2011 to identify the specific countries and commodities that contribute to increasing and decreasing inequality in global food availability relative to food production. Overall, international trade reduced inequality in food availability by 25%-33% relative to the distribution of food production, depending on the year. Across all years, about 58% of the total trade links acted to reduce inequality with similar to 4% of the links providing 95% of the reduction in inequality. Exports from United States of America, Malaysia, Argentina, and Canada are particularly important in decreasing inequality. Specific commodities that reduce inequality when traded include cereals and vegetables. Some trade connections contribute to increasing inequality, but this effect is mostly concentrated within a small number of commodities including fruits, stimulants, and nuts. In terms of specific countries, exports from Slovenia, Oman, Singapore, and Germany act to increase overall inequality. Collectively, our analysis and results represent an opportunity for building an enhanced understanding of global-scale patterns in food availability.
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| 5. |
- D'Odorico, Paolo, et al.
(författare)
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Food Inequality, Injustice, and Rights
- 2019
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Ingår i: BioScience. - : Oxford University Press. - 0006-3568 .- 1525-3244. ; 69:3, s. 180-190
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Tidskriftsartikel (refereegranskat)abstract
- As humanity continues to grow in size, questions related to human rights and the existing unequal distribution of food resources have taken on greater urgency. Is inequality in food access unjust or a regrettable consequence of the geographic distribution of biophysical resources? To what extent are there obligations to redress inequalities in access to food? We draw from a human rights perspective to identify obligations associated with access to food and develop a quantitative framework to evaluate the fulfillment of the human right to food. We discuss the capacity of socioeconomic development to reduce inequalities in per capita food availability with respect to the distribution of biophysical resources among countries. Although, at the country level, international trade shows the capacity to reduce human rights deficits by increasing food availability in countries with limited food production, whether it actually improves the fulfillment of the right to food will depend on within-country inequality.
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| 6. |
- D'Odorico, Paolo, et al.
(författare)
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The global Food-Energy-Water Nexus
- 2018
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Ingår i: Reviews of geophysics. - : American Geophysical Union (AGU). - 8755-1209 .- 1944-9208. ; 56:3, s. 456-531
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Forskningsöversikt (refereegranskat)abstract
- Water availability is a major factor constraining humanity's ability to meet the future food and energy needs of a growing and increasingly affluent human population. Water plays an important role in the production of energy, including renewable energy sources and the extraction of unconventional fossil fuels that are expected to become important players in future energy security. The emergent competition for water between the food and energy systems is increasingly recognized in the concept of the "food-energy-water nexus." The nexus between food and water is made even more complex by the globalization of agriculture and rapid growth in food trade, which results in a massive virtual transfer of water among regions and plays an important role in the food and water security of some regions. This review explores multiple components of the food-energy-water nexus and highlights possible approaches that could be used to meet food and energy security with the limited renewable water resources of the planet. Despite clear tensions inherent in meeting the growing and changing demand for food and energy in the 21st century, the inherent linkages among food, water, and energy systems can offer an opportunity for synergistic strategies aimed at resilient food, water, and energy security, such as the circular economy.
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| 7. |
- Fader, Marianela, et al.
(författare)
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Past and present biophysical redundancy of countries as a buffer to changes in food supply
- 2016
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Ingår i: Environmental Research Letters. - : IOP Publishing. - 1748-9326. ; 11:5
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Tidskriftsartikel (refereegranskat)abstract
- Spatially diverse trends in population growth, climate change, industrialization, urbanization and economic development are expected to change future food supply and demand. These changes may affect the suitability of land for food production, implying elevated risks especially for resource-constrained, food-importing countries. We present the evolution of biophysical redundancy for agricultural production at country level, from 1992 to 2012. Biophysical redundancy, defined as unused biotic and abiotic environmental resources, is represented by the potential food production of 'spare land', available water resources (i.e., not already used for human activities), as well as production increases through yield gap closure on cultivated areas and potential agricultural areas. In 2012, the biophysical redundancy of 75 (48) countries, mainly in North Africa, Western Europe, the Middle East and Asia, was insufficient to produce the caloric nutritional needs for at least 50% (25%) of their population during a year. Biophysical redundancy has decreased in the last two decades in 102 out of 155 countries, 11 of these went from high to limited redundancy, and nine of these from limited to very low redundancy. Although the variability of the drivers of change across different countries is high, improvements in yield and population growth have a clear impact on the decreases of redundancy towards the very low redundancy category. We took a more detailed look at countries classified as 'Low Income Economies (LIEs)' since they are particularly vulnerable to domestic or external food supply changes, due to their limited capacity to offset for food supply decreases with higher purchasing power on the international market. Currently, nine LIEs have limited or very low biophysical redundancy. Many of these showed a decrease in redundancy over the last two decades, which is not always linked with improvements in per capita food availability.
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| 8. |
- Gatenby, Robert A., et al.
(författare)
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Lung adenocarcinomas without driver genes converge to common adaptive strategies through diverse genetic, epigenetic, and niche construction evolutionary pathways
- 2024
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Ingår i: Medical Oncology. - 1357-0560. ; 41:6
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Tidskriftsartikel (refereegranskat)abstract
- Somatic evolution selects cancer cell phenotypes that maximize survival and proliferation in dynamic environments. Although cancer cells are molecularly heterogeneous, we hypothesized convergent adaptive strategies to common host selection forces can be inferred from patterns of epigenetic and genetic evolutionary selection in similar tumors. We systematically investigated gene mutations and expression changes in lung adenocarcinomas with no common driver genes (n = 313). Although 13,461 genes were mutated in at least one sample, only 376 non-synonymous mutations evidenced positive evolutionary selection with conservation of 224 genes, while 1736 and 2430 genes exhibited ≥ two-fold increased and ≥ 50% decreased expression, respectively. Mutations under positive selection are more frequent in genes with significantly altered expression suggesting they often “hardwire” pre-existing epigenetically driven adaptations. Conserved genes averaged 16-fold higher expression in normal lung tissue compared to those with selected mutations demonstrating pathways necessary for both normal cell function and optimal cancer cell fitness. The convergent LUAD phenotype exhibits loss of differentiated functions and cell–cell interactions governing tissue organization. Conservation with increased expression is found in genes associated with cell cycle, DNA repair, p53 pathway, epigenetic modifiers, and glucose metabolism. No canonical driver gene pathways exhibit strong positive selection, but extensive down-regulation of membrane ion channels suggests decreased transmembrane potential may generate persistent proliferative signals. NCD LUADs perform niche construction generating a stiff, immunosuppressive microenvironment through selection of specific collagens and proteases. NCD LUADs evolve to a convergent phenotype through a network of interconnected genetic, epigenetic, and ecological pathways.
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| 9. |
- Seekell, David A., et al.
(författare)
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Upscaling carbon dioxide emissions from lakes
- 2014
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Ingår i: Geophysical Research Letters. - 0094-8276 .- 1944-8007. ; 41:21, s. 7555-7559
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Tidskriftsartikel (refereegranskat)abstract
- Quantifying CO2 fluxes from lakes to the atmosphere is important for balancing regional and global-scale carbon budgets. CO2 emissions are estimated through statistical upscaling procedures that aggregate data from a large number of lakes. However, aggregation can bias flux estimates if the physical and chemical factors determining CO2 exchange between water and the atmosphere are not independent. We evaluated the magnitude of aggregation biases with moment expansions and pCO(2) data from 5140 Swedish lakes. The direction of the aggregation bias depends on lake size; mean flux was overestimated by 4% for small lakes (0.01-0.1 km(2)) but underestimated by 13% for large lakes (100-1000 km(2)). Simple covariance-based correction factors were generated to adjust for upscaling biases. These correction factors represent an easily interpretable and implemented approach to improving the accuracy of regional and global estimates of lake CO2 emissions.
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| 10. |
- Speliotes, Elizabeth K, et al.
(författare)
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Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits.
- 2011
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Ingår i: PLoS genetics. - : Public Library of Science (PLoS). - 1553-7404. ; 7:3
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Tidskriftsartikel (refereegranskat)abstract
- Nonalcoholic fatty liver disease (NAFLD) clusters in families, but the only known common genetic variants influencing risk are near PNPLA3. We sought to identify additional genetic variants influencing NAFLD using genome-wide association (GWA) analysis of computed tomography (CT) measured hepatic steatosis, a non-invasive measure of NAFLD, in large population based samples. Using variance components methods, we show that CT hepatic steatosis is heritable (∼26%-27%) in family-based Amish, Family Heart, and Framingham Heart Studies (n=880 to 3,070). By carrying out a fixed-effects meta-analysis of genome-wide association (GWA) results between CT hepatic steatosis and ∼2.4 million imputed or genotyped SNPs in 7,176 individuals from the Old Order Amish, Age, Gene/Environment Susceptibility-Reykjavik study (AGES), Family Heart, and Framingham Heart Studies, we identify variants associated at genome-wide significant levels (p<5×10(-8)) in or near PNPLA3, NCAN, and PPP1R3B. We genotype these and 42 other top CT hepatic steatosis-associated SNPs in 592 subjects with biopsy-proven NAFLD from the NASH Clinical Research Network (NASH CRN). In comparisons with 1,405 healthy controls from the Myocardial Genetics Consortium (MIGen), we observe significant associations with histologic NAFLD at variants in or near NCAN, GCKR, LYPLAL1, and PNPLA3, but not PPP1R3B. Variants at these five loci exhibit distinct patterns of association with serum lipids, as well as glycemic and anthropometric traits. We identify common genetic variants influencing CT-assessed steatosis and risk of NAFLD. Hepatic steatosis associated variants are not uniformly associated with NASH/fibrosis or result in abnormalities in serum lipids or glycemic and anthropometric traits, suggesting genetic heterogeneity in the pathways influencing these traits.
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