| 1. |
- Liang, Jia-xu, et al.
(författare)
-
An individual patient data meta-analysis to determine cut-offs for and confounders of NAFLD-fibrosis staging with magnetic resonance elastography
- 2023
-
Ingår i: Journal of Hepatology. - : Elsevier. - 0168-8278 .- 1600-0641. ; 79:3
-
Tidskriftsartikel (refereegranskat)abstract
- Background & Aims: We conducted an individual patient data meta-analysis to establish stiffness cut-off values for magnetic resonance elastography (MRE) in staging liver fibrosis and to assess potential confounding factors. Methods: A systematic review of the literature identified studies reporting MRE data in patients with NAFLD. Data were obtained from the corresponding authors. The pooled diagnostic cut-off value for the various fibrosis stages was determined in a two-stage meta-analysis. Multilevel modelling methods were used to analyse potential confounding factors influencing the diagnostic accuracy of MRE in staging liver fibrosis. Results: Eight independent cohorts comprising 798 patients were included in the meta-analysis. The area under the receiver operating characteristic curve (AUROC) for MRE in detecting significant fibrosis was 0.92 (sensitivity, 79%; specificity, 89%). For advanced fibrosis, the AUROC was 0.92 (sensitivity, 87%; specificity, 88%). For cirrhosis, the AUROC was 0.94 (sensitivity, 88%, specificity, 89%). Cut-offs were defined to explore concordance between MRE and histopathology: 0.05) and high gamma-glutamyl transferase (GGT) concentration ( 120U/L) (odds ratio 3.388, 95% CI 1.577- 7.278, p <0.01] were significantly associated with elevated liver stiffness, and thus affecting accuracy in staging early fibrosis (F0-F1). Steatosis, as measured by magnetic resonance imaging proton density fat fraction, and body mass index(BMI) were not confounders. Conclusions: MRE has excellent diagnostic performance for significant, advanced fibrosis and cirrhosis in patients with NAFLD. Elevated inflammatory activity and GGT level may lead to overestimation of early liver fibrosis, but anthropometric measures such as BMI or the degree of steatosis do not. <(c)> 2023 The Author(s). Published by Elsevier B.V. on behalf of European Association for the Study of the Liver. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
|
|
| 3. |
- Zirgulis, Giedrius, et al.
(författare)
-
Temperature evolution around four laboratory-scale borehole heat exchangers grouted with phase change materials subjected to heating–cooling cycles : An experimental study
- 2023
-
Ingår i: Journal of Energy Storage. - : Elsevier Ltd. - 2352-152X .- 2352-1538. ; 74
-
Tidskriftsartikel (refereegranskat)abstract
- This article presents the experimental results from a unique laboratory test-setup used to comparative study of heat transfer conditions in borehole heat exchangers with different grouts under a controlled environment. The work was part of a larger, EU-funded project on advanced materials for borehole heat exchangers pipes and grout, GEOCOND. Four grout columns with different formulations were cast and tested under cyclic heating and cooling. One grout column was cast using high thermal conductivity grout; two columns were cast from high thermal conductivity grout with microencapsulated phase change material (MC-PCM) and one with shape-stabilised phase-change material (SS-PCM). The objective of the test was to comparatively evaluate performance of the borehole heat exchanger under a cyclic temperature regime and to investigate if the selected phase change materials (PCM) embedded in grout can be activated by cyclic heating and function steadily. Twenty-five heating-cooling cycles were performed, each lasted 24 h. The results showed clear cooling delay in grouts containing PCM associated with the crystallization heat release. The cooling delay was better expressed in grouts with SS-PCM. The PCM related cooling delay was stable throughout all the cycling in SS-PCM containing grouts, however, the effect vanished in grouts with MC-PCM. © 2023 The Authors
|
|
