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- Lindström, Bengt, et al.
(författare)
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The effectiveness of the salutogenic approach to health promotion according to the Ottawa Charter principles and action areas.
- 2011
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Ingår i: International Conference on Assets for Health and Wellbeing across the Life Course.
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Konferensbidrag (refereegranskat)abstract
- Since health promotion was launched in 1986 through the Ottawa Charter it has suffered from the lack of a good theoretical foundation. However, it has now been demonstrated that the original salutogenic theory (The Sense of Coherence Theory of Antonovsky) matches the principles of the Ottawa Charter (OC). The evidence of a global systematic review on SOC proves that people and systems that have developed a strong SOC have a positive health outcome regarding the OC action areas. In 2007 IUHPE established a Global Working Group on Salutogenesis (GWG-SAL). In December 2010 10 research centers formed a core group for the GWG-SAL. These centers represent different profiles related to salutogenesis such as pollicy development, reorientation of health services, settings approaches such as workplace health, community action, health behaviours and learning for health, NCD interventions, development of research methods and indicators, contemporary evidence base and systematic reviews, the life-course approach, mental health, quality of life, population health and specific target groups such as youth and elderly... The proposed subkeynote/workshop or symposium proposes to coherently address these aspects where representatives of the Core Group speak to the core aspects of the above issues and discuss further research and interventions regarding the salutogenic approach to health and health promotion.
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- Pellagatti, Andrea, et al.
(författare)
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Lenalidomide inhibits the malignant clone and up-regulates the SPARC gene mapping to the commonly deleted region in 5q-syndrome patients
- 2007
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Ingår i: Proceedings of the National Academy of Sciences. - : Proceedings of the National Academy of Sciences. - 1091-6490 .- 0027-8424. ; 104:27, s. 11406-11411
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Tidskriftsartikel (refereegranskat)abstract
- Myelodysplastic syndromes (MDSs) are a group of hematopoietic stem cell disorders characterized by ineffective hernatopoiesis and peripheral blood cytopenias. Lenalidomide has dramatic therapeutic effects in patients with low-risk MDS and a chromosome 5q31 deletion, resulting in complete cytogenetic remission in >60% of patients. The molecular basis of this remarkable drug response is unknown. To gain insight into the molecular targets of lenaliclomide we investigated its in vitro effects on growth, maturation, and global gene expression in isolated erythroblast cultures from MDS patients with clel(5)(q3l). Lenalidomide inhibited growth of differentiating del(5q) erythroblasts but did not affect cytogenetically normal cells. Moreover, lenalidomide significantly influenced the pattern of gene expression in del(5q) intermediate erythroblasts, with the V51G4, PPIC, TPBG, activin A, and SPARC genes up-regulated by >2-fold in all samples and many genes involved in erythropoiesis, including HBA2, GYPA, and KLF1, down-regulated in most samples. Activin A, one of the most significant differentially expressed genes between lenalidomide-treated cells from MDS patients and healthy controls, has pleiotropic functions, including apoptosis of hematopoietic cells. Up-regulation and increased protein expression of the tumor suppressor gene SPARC is of particular interest because it is anti proliferative, antiadhesive, and antiangiogenic and is located at 5q3l-q32, within the commonly deleted region in MDS 5q- syndrome. We conclude that lenalidomide inhibits growth of del(5q) erythroid progenitors and that the up-regulation of SPARC and activin A may underlie the potent effects of lenalidomide in MDS with clel(5)(q3l). SPARCmay play a role in the pathogenesis of the 5q- syndrome.
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