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Sökning: WFRF:(Cavarelli J)

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1.
  • Marlin, R, et al. (författare)
  • Targeting SARS-CoV-2 receptor-binding domain to cells expressing CD40 improves protection to infection in convalescent macaques
  • 2021
  • Ingår i: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 12:1, s. 5215-
  • Tidskriftsartikel (refereegranskat)abstract
    • Achieving sufficient worldwide vaccination coverage against SARS-CoV-2 will require additional approaches to currently approved viral vector and mRNA vaccines. Subunit vaccines may have distinct advantages when immunizing vulnerable individuals, children and pregnant women. Here, we present a new generation of subunit vaccines targeting viral antigens to CD40-expressing antigen-presenting cells. We demonstrate that targeting the receptor-binding domain (RBD) of the SARS-CoV-2 spike protein to CD40 (αCD40.RBD) induces significant levels of specific T and B cells, with long-term memory phenotypes, in a humanized mouse model. Additionally, we demonstrate that a single dose of the αCD40.RBD vaccine, injected without adjuvant, is sufficient to boost a rapid increase in neutralizing antibodies in convalescent non-human primates (NHPs) exposed six months previously to SARS-CoV-2. Vaccine-elicited antibodies cross-neutralize different SARS-CoV-2 variants, including D614G, B1.1.7 and to a lesser extent B1.351. Such vaccination significantly improves protection against a new high-dose virulent challenge versus that in non-vaccinated convalescent animals.
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2.
  • Lâiné, Mickäel, et al. (författare)
  • Navigation System for a Small Size Lunar Exploration Rover With a Monocular Omnidirectional Camera
  • 2016
  • Ingår i: Proc. of SPIE Vol. 10011, 100111M. - : SPIE - International Society for Optical Engineering.
  • Konferensbidrag (refereegranskat)abstract
    • A lunar rover requires an accurate localisation system in order to operate in an uninhabited environment.However, every additional piece of equipment mounted on it drastically increases the overall cost of the mission.This paper reports a possible solution for a micro-rover using a sole monocular omnidirectional camera. Ourapproach relies on a combination of feature tracking and template matching for Visual Odometry. The resultsare afterwards re ned using a Graph-Based SLAM algorithm, which also provides a sparse reconstruction of theterrain. We tested the algorithm on a lunar rover prototype in a lunar analogue environment and the experimentsshow that the estimated trajectory is accurate and the combination with the template matching algorithm allowsan otherwise poor detection of spot turns.
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