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| 2. |
- Capala, Jacek, et al.
(författare)
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Clinical BNCT studies in Sweden
- 2002
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Ingår i: Research and development in neutron capture therapy. - : Monduzzi Editore Print. ; , s. 1101-
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 3. |
- Möller, Torgil, et al.
(författare)
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Radiotherapy techniques in current use in Sweden.
- 2003
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Ingår i: Acta Oncologica. - : Informa UK Limited. - 1651-226X .- 0284-186X. ; 42:5-6, s. 376-386
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Tidskriftsartikel (refereegranskat)abstract
- A systematic assessment of radiotherapy for cancer was conducted by The Swedish Council on Technology Assessment in Health Care (SBU) in 2001. The assessment included a review of radiotherapy techniques in current use in Sweden. The following conclusions were drawn: Radiotherapy demands adequate knowledge of diagnostic methods, anatomy, cancer biology and of the physical and biological properties of ionizing radiation. Well-functioning teamwork on the part of the oncologist, medical physicist and oncology nurse is important.Radiotherapy has a high degree of technical sophistication, including the use of computers, which necessitates expert technical support.Technical development is rapid, and since the previous report, multileaf collimators and electronic portal imaging have been introduced in the clinical routine.The use of brachytherapy for treatment of non-gynaecological malignancies is rapidly increasing.The need for quality assurance in all steps of the radiotherapy procedure is stressed. A critical review of the literature on intraoperative radiotherapy is also included as an Appendix.
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| 4. |
- Wegdén, Marie, et al.
(författare)
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Nuclear microprobe analysis of the selective boron uptake obtained with BPA in brain tumour tissue
- 2004
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Ingår i: Nuclear Instruments & Methods in Physics Research. Section B: Beam Interactions with Materials and Atoms. - : Elsevier BV. - 0168-583X. ; 219-20, s. 67-71
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Tidskriftsartikel (refereegranskat)abstract
- The tumour selective ability of the boron compound boronophenylalanine (BPA), today used in Boron Neutron Capture Therapy in Sweden, has been investigated with the Lund Nuclear Microprobe. The tumour to tissue ratio of the boron concentration, as well as the location of boron within the cells, is critical for the efficiency of the therapy. It is desirable that the boron is accumulated as close as possible to the cell nucleus, since the alpha particles produced in the B-10(n,alpha)Li-7 reaction only have a range of about 10 microns, i.e. a cell diameter. The nuclear reaction B-11(p,alpha)2alpha, which has an especially high cross-section (300 mb) for 660 keV protons, has been used to analyse brain tissue from BPA-injected rats. Previous studies on other boron compounds have shown significant background problems when the alpha particles are detected in the backward direction. By a specially designed set-up, alpha particles in the forward and backward direction are detected simultaneously, and only the coincidences between the two directions are considered to be true boron events. In this way we could achieve excellent background suppression. The analysis shows that BPA indeed is tumour selective. Quantifications show a boron abundance of 150 +/- 20 ng/cm(2) in normal tissue and 567 70 ng/cm(2) in tumour tissue. If the rat is fed with L-dopa before the injection of BPA the uptake increases 3-4 times. The boron is homogeneously distributed in the cellular structure and no specific intracellular accumulation has been shown. (C) 2004 Elsevier B.V. All rights reserved.
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