| 1. |
- Cedergren, Alexander, et al.
(författare)
-
Challenges in Designing Resilient Socio-technical Systems: A Case Study of Railway Tunnel Projects
- 2011
-
Ingår i: Proceedings of the fourth resilience engineering symposium. - 9782911256479
-
Konferensbidrag (refereegranskat)abstract
- This paper presents a case study of decision-making at the design stage of a socio-technical system where resilience at the global level of the system was constrained by the local perspectives adopted by the different stakeholders. The study is based on interviews with key decision-makers involved in the design stage of six railway tunnel projects in Sweden. The results show that differences in roles and perspectives among the involved actors created double binds and led to extensive discussions and deadlocks during decision-making in the majority of the studied projects. In these projects agreements could only be reached by relying on the outcome from previous railway tunnel projects, regardless differences in project-specific aspects. A significant impact from local actors during decision-making increased the potential for suboptimizations and resulted in a limited focus on the system’s resilience from a regional and national perspective. The findings point at the need for more emphasis in the field of resilience engineering on crossorganisational aspects in order to gain increased understanding of the challenges related to improving resilience of socio-technical systems.
|
|
| 2. |
|
|
| 3. |
|
|
| 4. |
- Moberg, Christina, et al.
(författare)
-
De unga gör helt rätt när de stämmer staten
- 2022
-
Ingår i: Aftonbladet. - 1103-9000.
-
Tidskriftsartikel (populärvet., debatt m.m.)abstract
- 1 620 forskare och lärare i forskarvärlden: Vi ställer oss bakom Auroras klimatkrav
|
|
| 5. |
- Shang, Ming-Mei, et al.
(författare)
-
Lim domain binding 2 : a key driver of transendothelial migration of leukocytes and atherosclerosis
- 2014
-
Ingår i: Arteriosclerosis, Thrombosis and Vascular Biology. - 1079-5642 .- 1524-4636. ; 34:9, s. 2068-2077
-
Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE: Using a multi-tissue, genome-wide gene expression approach, we recently identified a gene module linked to the extent of human atherosclerosis. This atherosclerosis module was enriched with inherited risk for coronary and carotid artery disease (CAD) and overlapped with genes in the transendothelial migration of leukocyte (TEML) pathway. Among the atherosclerosis module genes, the transcription cofactor Lim domain binding 2 (LDB2) was the most connected in a CAD vascular wall regulatory gene network. Here, we used human genomics and atherosclerosis-prone mice to evaluate the possible role of LDB2 in TEML and atherosclerosis.APPROACH AND RESULTS: mRNA profiles generated from blood macrophages in patients with CAD were used to infer transcription factor regulatory gene networks; Ldlr(-/-)Apob(100/100) mice were used to study the effects of Ldb2 deficiency on TEML activity and atherogenesis. LDB2 was the most connected gene in a transcription factor regulatory network inferred from TEML and atherosclerosis module genes in CAD macrophages. In Ldlr(-/-)Apob(100/100) mice, loss of Ldb2 increased atherosclerotic lesion size ≈2-fold and decreased plaque stability. The exacerbated atherosclerosis was caused by increased TEML activity, as demonstrated in air-pouch and retinal vasculature models in vivo, by ex vivo perfusion of primary leukocytes, and by leukocyte migration in vitro. In THP1 cells, migration was increased by overexpression and decreased by small interfering RNA inhibition of LDB2. A functional LDB2 variant (rs10939673) was associated with the risk and extent of CAD across several cohorts.CONCLUSIONS: As a key driver of the TEML pathway in CAD macrophages, LDB2 is a novel candidate to target CAD by inhibiting the overall activity of TEML.
|
|
| 6. |
- Wahlberg, Eric, et al.
(författare)
-
Development of Graphene Quantum Hall Effect AC Metrology at RISE
- 2024
-
Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- We present the first steps taken towards a graphene quantum Hall effect ac resistance standard at RISE. A new measurement setup has been developed including a graphene quantum Hall effect device suitable for the kilohertz range and a coaxial cryoprobe to be used together with a coaxial impedance bridge based on inductive voltage dividers. 1:1 ratio resistance measurements of the graphene device against a 12.9 kΩ ac resistance standard resulted in a linear frequency dependent (≈ 0.2(μΩ/Ω)/kHz) deviation from the quantized dc value.
|
|
