| 1. |
- Mateus Brandão, Luiz Eduardo, et al.
(författare)
-
Exposure to a more unhealthy diet impacts sleep microstructure during normal sleep and recovery sleep : A randomized trial
- 2023
-
Ingår i: Obesity. - : John Wiley & Sons. - 1930-7381 .- 1930-739X. ; 31:7, s. 1755-1766
-
Tidskriftsartikel (refereegranskat)abstract
- ObjectiveAlthough intake of specific macronutrients has been associated with sleep parameters, interventional evidence is lacking. Therefore, this randomized trial was conducted to examine how a more unhealthy high-fat/high-sugar (HFHS) diet impacts sleep in humans.MethodsIn a crossover study, 15 healthy young men consumed two isocaloric diets in random order for a week: an HFHS and a low-fat/low-sugar diet. Following each diet, in-lab sleep was recorded using polysomnography during a full night of sleep and during recovery sleep after extended wakefulness. Sleep duration, macrostructure, and microstructure (oscillatory pattern and slow waves) were investigated using machine learning-based algorithms.ResultsSleep duration did not differ across the diets based on actigraphy and the in-lab polysomnography. Sleep macrostructure was similar after 1 week on each diet. Compared with the low-fat/low-sugar diet, consumption of the HFHS diet resulted in reduced delta power, delta to beta ratio, and slow wave amplitude but increased alpha and theta power during deep sleep. During recovery sleep, similar sleep oscillatory changes were observed.ConclusionsShort-term consumption of a more unhealthy diet alters sleep oscillatory features that regulate the restorative properties of sleep. Whether such changes can mediate adverse health outcomes associated with consumption of an unhealthier diet warrants investigation.
|
|
| 2. |
- Cable, Jennifer, et al.
(författare)
-
Sleep and circadian rhythms : pillars of health-a Keystone Symposia report
- 2021
-
Ingår i: Annals of the New York Academy of Sciences. - : John Wiley & Sons. - 0077-8923 .- 1749-6632. ; 1506:1, s. 18-34
-
Tidskriftsartikel (refereegranskat)abstract
- The human circadian system consists of the master clock in the suprachiasmatic nuclei of the hypothalamus as well as in peripheral molecular clocks located in organs throughout the body. This system plays a major role in the temporal organization of biological and physiological processes, such as body temperature, blood pressure, hormone secretion, gene expression, and immune functions, which all manifest consistent diurnal patterns. Many facets of modern life, such as work schedules, travel, and social activities, can lead to sleep/wake and eating schedules that are misaligned relative to the biological clock. This misalignment can disrupt and impair physiological and psychological parameters that may ultimately put people at higher risk for chronic diseases like cancer, cardiovascular disease, and other metabolic disorders. Understanding the mechanisms that regulate sleep circadian rhythms may ultimately lead to insights on behavioral interventions that can lower the risk of these diseases. On February 25, 2021, experts in sleep, circadian rhythms, and chronobiology met virtually for the Keystone eSymposium "Sleep & Circadian Rhythms: Pillars of Health" to discuss the latest research for understanding the bidirectional relationships between sleep, circadian rhythms, and health and disease.
|
|
| 3. |
- Cedernaes, Jonathan, et al.
(författare)
-
Transcriptional Basis for Rhythmic Control of Hunger and Metabolism within the AgRP Neuron
- 2019
-
Ingår i: Cell Metabolism. - : Elsevier BV. - 1550-4131 .- 1932-7420. ; 29:5, s. 1078-1091.e5
-
Tidskriftsartikel (refereegranskat)abstract
- The alignment of fasting and feeding with the sleep/ wake cycle is coordinated by hypothalamic neurons, though the underlying molecular programs remain incompletely understood. Here, we demonstrate that the clock transcription pathway maximizes eating during wakefulness and glucose production during sleep through autonomous circadian regulation of NPY/AgRP neurons. Tandem profiling of whole-cell and ribosome-bound mRNAs in morning and evening under dynamic fasting and fed conditions identified temporal control of activity-dependent gene repertoires in AgRP neurons central to synaptogenesis, bioenergetics, and neurotransmitter and peptidergic signaling. Synaptic and circadian pathways were specific to whole-cell RNA analyses, while bioenergetic pathways were selectively enriched in the ribosome-bound transcriptome. Finally, we demonstrate that the AgRP clock mediates the transcriptional response to leptin. Our results reveal that time-of-day restriction in transcriptional control of energy-sensing neurons underlies the alignment of hunger and food acquisition with the sleep/wake state.
|
|
| 4. |
- Eriksson Lundström, Jenny, et al.
(författare)
-
Featuring Sustainability - social sustainability impact of Open Innovation Software
- 2012
-
Ingår i: The proceedings of the 5th ISPIM Innovation Symposium.
-
Konferensbidrag (refereegranskat)abstract
- As ICT has shown itself useful when it comes to promoting sustainability performance internally as well as externally to the organization, it also relates to the concept of sustainable development. Unfortunately, research on features of Open Innovation Software and their sustainability impact, as well as more general research on Open Innovation and organizational sustainability performance are scarce. By means of the core areas of sustainability Bengtsson et al 2012 we research sustainability relatedness of common features of idea management systems. The research shows that the investigated features are mainly directed towards providing user engagement, while features related to transparency, incentives and efficiency all may be seen as indirect effects of providing for user engagement in the idea management system. As a consequence, issues related to transparency, incentives and efficiency that may ensure innovativeness of the ideas and positive social sustainability as an outcome of the user experience, are placed on the manager.
|
|
| 5. |
|
|
| 6. |
- Levine, Daniel C., et al.
(författare)
-
NADH inhibition of SIRT1 links energy state to transcription during time-restricted feeding
- 2021
-
Ingår i: Nature Metabolism. - : Springer Nature. - 2522-5812. ; 3:12, s. 1621-1632
-
Tidskriftsartikel (refereegranskat)abstract
- In mammals, circadian rhythms are entrained to the light cycle and drive daily oscillations in levels of NAD+, a cosubstrate of the class III histone deacetylase sirtuin 1 (SIRT1) that associates with clock transcription factors. Although NAD+ also participates in redox reactions, the extent to which NAD(H) couples nutrient state with circadian transcriptional cycles remains unknown. Here we show that nocturnal animals subjected to time-restricted feeding of a calorie-restricted diet (TRF-CR) only during night-time display reduced body temperature and elevated hepatic NADH during daytime. Genetic uncoupling of nutrient state from NADH redox state through transduction of the water-forming NADH oxidase from Lactobacillus brevis (LbNOX) increases daytime body temperature and blood and liver acyl-carnitines. LbNOX expression in TRF-CR mice induces oxidative gene networks controlled by brain and muscle Arnt-like protein 1 (BMAL1) and peroxisome proliferator-activated receptor alpha (PPARα) and suppresses amino acid catabolic pathways. Enzymatic analyses reveal that NADH inhibits SIRT1 in vitro, corresponding with reduced deacetylation of SIRT1 substrates during TRF-CR in vivo. Remarkably, Sirt1 liver nullizygous animals subjected to TRF-CR display persistent hypothermia even when NADH is oxidized by LbNOX. Our findings reveal that the hepatic NADH cycle links nutrient state to whole-body energetics through the rhythmic regulation of SIRT1.
|
|
