| 1. |
|
|
| 2. |
- Galluzzi, L, et al.
(författare)
-
Consensus guidelines for the definition, detection and interpretation of immunogenic cell death
- 2020
-
Ingår i: Journal for immunotherapy of cancer. - : BMJ. - 2051-1426. ; 8:1
-
Tidskriftsartikel (refereegranskat)abstract
- Cells succumbing to stress via regulated cell death (RCD) can initiate an adaptive immune response associated with immunological memory, provided they display sufficient antigenicity and adjuvanticity. Moreover, multiple intracellular and microenvironmental features determine the propensity of RCD to drive adaptive immunity. Here, we provide an updated operational definition of immunogenic cell death (ICD), discuss the key factors that dictate the ability of dying cells to drive an adaptive immune response, summarize experimental assays that are currently available for the assessment of ICD in vitro and in vivo, and formulate guidelines for their interpretation.
|
|
| 3. |
- Cesano, A, et al.
(författare)
-
Society for Immunotherapy of Cancer clinical and biomarkers data sharing resource document: Volume II-practical challenges
- 2020
-
Ingår i: Journal for immunotherapy of cancer. - : BMJ. - 2051-1426. ; 8:2
-
Tidskriftsartikel (refereegranskat)abstract
- The development of strongly predictive validated biomarkers is essential for the field of immuno-oncology (IO) to advance. The highly complex, multifactorial data sets required to develop these biomarkers necessitate effective, responsible data-sharing efforts in order to maximize the scientific knowledge and utility gained from their collection. While the sharing of clinical- and safety-related trial data has already been streamlined to a large extent, the sharing of biomarker-aimed clinical trial derived data and data sets has been met with a number of hurdles that have impaired the progression of biomarkers from hypothesis to clinical use. These hurdles include technical challenges associated with the infrastructure, technology, workforce, and sustainability required for clinical biomarker data sharing. To provide guidance and assist in the navigation of these challenges, the Society for Immunotherapy of Cancer (SITC) Biomarkers Committee convened to outline the challenges that researchers currently face, both at the conceptual level (Volume I) and at the technical level (Volume II). The committee also suggests possible solutions to these problems in the form of professional standards and harmonized requirements for data sharing, assisting in continued progress toward effective, clinically relevant biomarkers in the IO setting.
|
|
| 4. |
- Rutella, S, et al.
(författare)
-
Society for Immunotherapy of Cancer clinical and biomarkers data sharing resource document: Volume I-conceptual challenges
- 2020
-
Ingår i: Journal for immunotherapy of cancer. - : BMJ. - 2051-1426. ; 8:2
-
Tidskriftsartikel (refereegranskat)abstract
- The sharing of clinical trial data and biomarker data sets among the scientific community, whether the data originates from pharmaceutical companies or academic institutions, is of critical importance to enable the development of new and improved cancer immunotherapy modalities. Through data sharing, a better understanding of current therapies in terms of their efficacy, safety and biomarker data profiles can be achieved. However, the sharing of these data sets involves a number of stakeholder groups including patients, researchers, private industry, scientific journals and professional societies. Each of these stakeholder groups has differing interests in the use and sharing of clinical trial and biomarker data, and the conflicts caused by these differing interests represent significant obstacles to effective, widespread sharing of data. Thus, the Society for Immunotherapy of Cancer (SITC) Biomarkers Committee convened to identify the current barriers to biomarker data sharing in immuno-oncology (IO) and to help in establishing professional standards for the responsible sharing of clinical trial data. The conclusions of the committee are described in two position papers: Volume I—conceptual challenges and Volume II—practical challenges, the first of which is presented in this manuscript. Additionally, the committee suggests actions by key stakeholders in the field (including organizations and professional societies) as the best path forward, encouraging the cultural shift needed to ensure responsible data sharing in the IO research setting.
|
|
| 5. |
|
|
| 6. |
|
|
| 7. |
- Cesano, Daniele, et al.
(författare)
-
Parameters regulating groundwater inflows into hard rock tunnels - a statistical study of the Bolmen tunnel in southern Sweden
- 2000
-
Ingår i: Tunnelling and Underground Space Technology. - 0886-7798 .- 1878-4364. ; 15:2, s. 153-165
-
Tidskriftsartikel (refereegranskat)abstract
- Inflow of groundwater into tunnels has always been a major technical and environmental problem for underground constructions. Predictions of groundwater inflow using analytical and numerical tools have often failed due to generalization and simplification of important parameters, especially in heterogeneous media such as crystalline rocks. In order to identify those parameters that regulate inflows, a systematic statistical analysis has been carried out at a tunnel constructed in the hard crystalline rocks of southern Sweden. The parameters included topographically, technically and geologically important variables in the hard crystalline rocks as well as in the overburden. The study revealed that many factors related to the rock quality, as well as to the overburden-such as the number of fractures, the thickness of the overburden, the soil type and the amount of pregrouting-regulated the leakage. It seems that a clear difference exists between the parameters that regulate the major and the minor leakage. The minor leakage is associated more with the drainage of the rock mass, while the major leakage is clearly associated with different parameters in the overburden. Unless the overburden anal the rock mass are considered as an interrelated system, predictions of groundwater inflows are likely to fail.
|
|
| 8. |
|
|
| 9. |
|
|
| 10. |
|
|
