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Sökning: WFRF:(Chadi G)

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  • Zhou, Wei, et al. (författare)
  • Global Biobank Meta-analysis Initiative : Powering genetic discovery across human disease
  • 2022
  • Ingår i: Cell Genomics. - : Elsevier. - 2666-979X. ; 2:10
  • Tidskriftsartikel (refereegranskat)abstract
    • Biobanks facilitate genome-wide association studies (GWASs), which have mapped genomic loci across a range of human diseases and traits. However, most biobanks are primarily composed of individuals of European ancestry. We introduce the Global Biobank Meta-analysis Initiative (GBMI)-a collaborative network of 23 biobanks from 4 continents representing more than 2.2 million consented individuals with genetic data linked to electronic health records. GBMI meta-analyzes summary statistics from GWASs generated using harmonized genotypes and phenotypes from member biobanks for 14 exemplar diseases and endpoints. This strategy validates that GWASs conducted in diverse biobanks can be integrated despite heterogeneity in case definitions, recruitment strategies, and baseline characteristics. This collaborative effort improves GWAS power for diseases, benefits understudied diseases, and improves risk prediction while also enabling the nomination of disease genes and drug candidates by incorporating gene and protein expression data and providing insight into the underlying biology of human diseases and traits.
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  • Chadi, Abd Alrahman, et al. (författare)
  • Note : Simple and compact piezoelectric mirror actuator with 100 kHz bandwidth, using standard components
  • 2013
  • Ingår i: Review of Scientific Instruments. - : AIP Publishing. - 0034-6748 .- 1089-7623. ; 84:5, s. 056112-
  • Tidskriftsartikel (refereegranskat)abstract
    • We propose a mounting scheme to control the displacement of a mirror (or other small object) by a cylindrical piezoelectric actuator, giving uniform response and no phase lag up to high frequencies. This requires a simple ring holder, and unmodified off-the-shelf components. In our implementation, the piezo-mirror assembly has its first mechanical resonance around 120 kHz, close to the resonance for the bare piezo. The idea is to decouple the fundamental elongation mode of the piezo-mirror assembly from the holder by side-clamping the assembly at its zero-displacement plane for this mode. The main drawback is a reduced mirror displacement, by a factor 2 in our case (mirror displacement is similar to 2.5 mu m). Also, the mirror needs to be light with respect to the piezo: still, we use a standard half-inch mirror. The resulting system is very compact as it fits inside a 1-in. commercial steering mirror post.
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