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- Tegenfeldt, Jonas O., et al.
(författare)
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Near-field scanner for moving molecules
- 2001
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Ingår i: Physical Review Letters. - 0031-9007. ; 86:7, s. 1378-1381
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Tidskriftsartikel (refereegranskat)abstract
- A new technology that provides high optical resolution as well as very high data rates for moving molecules is presented. An important aspect of the device is the dependence of both the near-field radiation pattern and the far-field transmission of a thin slit on the polarization of the incident light.
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| 3. |
- Chan, Shirley, et al.
(författare)
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Platform or infrastructure or both at once? : Detangling the two concept's knotty cross-articulations
- 2022
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Ingår i: Information Research. - : Elsevier BV. - 1368-1613. ; 27:Special issue
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Tidskriftsartikel (refereegranskat)abstract
- Introduction. With the ever-increasing presence of digital technology and media, scholars have explored the cross-articulations of infrastructure and platform to investigate the contemporary digital landscape. However, cross-articulations of the two concepts vary according to the empirical setting and focus. The present paper investigates the ways the two concepts relate to each other and their relevance to library and information science.Method/analysis. The findings were obtained from a conceptual review of the literature on cross- articulations of infrastructure and platform.Results. The cross-articulations were categorised as the interrelated forms of process and practice: first, cross-articulations are understood as processes that occur separately or simultaneously, altering the dynamic between public and private spheres and highlighting the scale, invisibility, and indispensability. Second, some cross-articulations encompass a practice-discursive dimension, emphasising the relations between different actors. The two selected cross-articulations are sustained by data-generating processes and practices involving both platform and users.Conclusions. Cross-articulations of platform and infrastructure can assist library and information scholars to conceptualise contemporary, datafied information infrastructures. The authors suggest including perspectives on user practices, aligned with the current focus on platforms, in future cross- articulations to gain greater insight into the user-platform dynamic.
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| 7. |
- Vigorito, Elena, et al.
(författare)
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Fine-Scale Mapping at 9p22.2 Identifies Candidate Causal Variants That Modify Ovarian Cancer Risk in BRCA1 and BRCA2 Mutation Carriers
- 2016
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Ingår i: PLOS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 11:7
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Tidskriftsartikel (refereegranskat)abstract
- Population-based genome wide association studies have identified a locus at 9p22.2 associated with ovarian cancer risk, which also modifies ovarian cancer risk in BRCA1 and BRCA2 mutation carriers. We conducted fine-scale mapping at 9p22.2 to identify potential causal variants in BRCA1 and BRCA2 mutation carriers. Genotype data were available for 15,252 (2,462 ovarian cancer cases) BRCA1 and 8,211 (631 ovarian cancer cases) BRCA2 mutation carriers. Following genotype imputation, ovarian cancer associations were assessed for 4,873 and 5,020 SNPs in BRCA1 and BRCA2 mutation carriers respectively, within a retrospective cohort analytical framework. In BRCA1 mutation carriers one set of eight correlated candidate causal variants for ovarian cancer risk modification was identified (top SNP rs10124837, HR: 0.73, 95% CI: 0.68 to 0.79, p-value 2x 10-16). These variants were located up to 20 kb upstream of BNC2. In BRCA2 mutation carriers one region, up to 45 kb upstream of BNC2, and containing 100 correlated SNPs was identified as candidate causal (top SNP rs62543585, HR: 0.69, 95% CI: 0.59 to 0.80, p-value 1.0 x 10-6). The candidate causal in BRCA1 mutation carriers did not include the strongest associated variant at this locus in the general population. In sum, we identified a set of candidate causal variants in a region that encompasses the BNC2 transcription start site. The ovarian cancer association at 9p22.2 may be mediated by different variants in BRCA1 mutation carriers and in the general population. Thus, potentially different mechanisms may underlie ovarian cancer risk for mutation carriers and the general population.
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