| 1. |
- Chaudhary, Amit, et al.
(författare)
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Correlating multi-functional role of cold shock domain proteins with intrinsically disordered regions
- 2022
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Ingår i: International Journal of Biological Macromolecules. - : Elsevier BV. - 0141-8130 .- 1879-0003. ; 220, s. 743-753
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Forskningsöversikt (refereegranskat)abstract
- Cold shock proteins (CSPs) are an ancient and conserved family of proteins. They are renowned for their role in response to low-temperature stress in bacteria and nucleic acid binding activities. In prokaryotes, cold and non-cold inducible CSPs are involved in various cellular and metabolic processes such as growth and development, osmotic oxidation, starvation, stress tolerance, and host cell invasion. In prokaryotes, cold shock condition reduces cell transcription and translation efficiency. Eukaryotic cold shock domain (CSD) proteins are evolved form of prokaryotic CSPs where CSD is flanked by N- and C-terminal domains. Eukaryotic CSPs are multi-functional proteins. CSPs also act as nucleic acid chaperons by preventing the formation of secondary structures in mRNA at low temperatures. In human, CSD proteins play a crucial role in the progression of breast cancer, colon cancer, lung cancer, and Alzheimer's disease. A well-defined three-dimensional structure of intrinsically disordered regions of CSPs family members is still undetermined. In this article, intrinsic disorder regions of CSPs have been explored systematically to understand the pleiotropic role of the cold shock family of proteins.
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| 2. |
- Chaudhary, Richa, 1988, et al.
(författare)
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Structural Positive Electrodes Engineered for Multifunctionality
- 2024
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Ingår i: Advanced Science. - 2198-3844 .- 2198-3844. ; In Press
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Tidskriftsartikel (refereegranskat)abstract
- Multifunctional structural batteries are of high and emerging interest in a wide variety of high-strength and lightweight applications. Structural batteries typically use pristine carbon fiber as the negative electrode, functionalized carbon fiber as the positive electrode, and a mechanically robust lithium-ion transporting electrolyte. However, electrochemical cycling of carbon fibre-based positive electrodes is still limited to tests in liquid electrolytes, which does not allow for to introduction of multifunctionality in real terms. To overcome these limitations, structural batteries with a structural battery electrolyte (SBE) are developed. This approach offers massless energy storage. The electrodes are manufactured using economically friendly, abundant, cheap, and non-toxic iron-based materials like olivine LiFePO4. Reduced graphene oxide, renowned for its high surface area and electrical conductivity, is incorporated to enhance the ion transport mechanism. Furthermore, a vacuum-infused solid-liquid electrolyte is cured to bolster the mechanical strength of the carbon fibers and provide a medium for lithium-ion migration. Electrophoretic deposition is selected as a green process to manufacture the structural positive electrodes with homogeneous mass loading. A specific capacity of 112 mAh g−1 can be reached at C/20, allowing the smooth transport of Li-ion in the presence of SBE. The modulus of positive electrodes exceeded 80 GPa. Structural battery-positive half-cells are demonstrated across various mass-loadings, enabling them to be tailored for a diverse array of applications in consumer technology, electric vehicles, and aerospace sectors.
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| 3. |
- James, SL, et al.
(författare)
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Global injury morbidity and mortality from 1990 to 2017: results from the Global Burden of Disease Study 2017
- 2020
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Ingår i: Injury prevention : journal of the International Society for Child and Adolescent Injury Prevention. - : BMJ. - 1475-5785. ; 26:SUPP_1Supp 1, s. 96-114
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Tidskriftsartikel (refereegranskat)abstract
- Past research in population health trends has shown that injuries form a substantial burden of population health loss. Regular updates to injury burden assessments are critical. We report Global Burden of Disease (GBD) 2017 Study estimates on morbidity and mortality for all injuries.MethodsWe reviewed results for injuries from the GBD 2017 study. GBD 2017 measured injury-specific mortality and years of life lost (YLLs) using the Cause of Death Ensemble model. To measure non-fatal injuries, GBD 2017 modelled injury-specific incidence and converted this to prevalence and years lived with disability (YLDs). YLLs and YLDs were summed to calculate disability-adjusted life years (DALYs).FindingsIn 1990, there were 4 260 493 (4 085 700 to 4 396 138) injury deaths, which increased to 4 484 722 (4 332 010 to 4 585 554) deaths in 2017, while age-standardised mortality decreased from 1079 (1073 to 1086) to 738 (730 to 745) per 100 000. In 1990, there were 354 064 302 (95% uncertainty interval: 338 174 876 to 371 610 802) new cases of injury globally, which increased to 520 710 288 (493 430 247 to 547 988 635) new cases in 2017. During this time, age-standardised incidence decreased non-significantly from 6824 (6534 to 7147) to 6763 (6412 to 7118) per 100 000. Between 1990 and 2017, age-standardised DALYs decreased from 4947 (4655 to 5233) per 100 000 to 3267 (3058 to 3505).InterpretationInjuries are an important cause of health loss globally, though mortality has declined between 1990 and 2017. Future research in injury burden should focus on prevention in high-burden populations, improving data collection and ensuring access to medical care.
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