| 1. |
- Chen, Bolin, et al.
(författare)
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LTE-WLAN Aggregation with Bursty Data Traffic and Randomized Flow Splitting
- 2019
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Ingår i: ICC 2019 - 2019 IEEE INTERNATIONAL CONFERENCE ON COMMUNICATIONS (ICC). - : IEEE. - 9781538680889 - 9781538680896
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Konferensbidrag (refereegranskat)abstract
- We investigate the effect of bursty traffic in an LTE and Wi-Fi aggregation (LWA)-enabled network, where part of the LTE traffic is offloaded to Wi-Fi access points (APs) to boost the performance of LTE networks. A Wi-Fi AP maintains two queues containing data intended for the LWA-mode user and the native Wi-Fi user, and it is allowed to serve them simultaneously by using superposition coding (SC). With respect to the existing works on LWA, the novelty of our study consists of a random access protocol allowing the Wi-Fi AP to serve the native Wi-Fi user with probabilities that depend on the queue size of the LWA-mode data. We analyze the throughput of the native Wi-Fi network, accounting for different transmitting probabilities of the queues, the traffic flow splitting between LTE and Wi-Fi, and the operating mode of the LWA user with both LTE and Wi-Fi interfaces. Our results provide fundamental insights in the throughput behavior of such aggregated systems, which are essential for further investigation in larger topologies.
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| 2. |
- Chen, Bolin, et al.
(författare)
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Modeling and Analysis of MPTCP Proxy-based LTE-WLAN Path Aggregation
- 2017
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Ingår i: 2017 IEEE Global Communications Conference (GLOBECOM), Proceedings Singapore 4 – 8 December 2017. - : IEEE Communications Society. - 9781509050192 - 9781509050208 ; , s. 1-7
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Konferensbidrag (refereegranskat)abstract
- Long Term Evolution (LTE)-Wireless Local Area Network (WLAN) Path Aggregation (LWPA) based on Multi- path Transmission Control Protocol (MPTCP) has been under standardization procedure as a promising and cost-efficient solution to boost Downlink (DL) data rate and handle the rapidly increasing data traffic. This paper aims at providing tractable analysis for the DL performance evaluation of large-scale LWPA networks with the help of tools from stochastic geometry. We consider a simple yet practical model to determine under which conditions a native WLAN Access Point (AP) will work under LWPA mode to help increasing the received data rate. Using stochastic spatial models for the distribution of WLAN APs and LTE Base Stations (BSs), we analyze the density of active LWPA- mode WiFi APs in the considered network model, which further leads to closed-form expressions on the DL data rate and area spectral efficiency (ASE) improvement. Our numerical results illustrate the impact of different network parameters on the performance of LWPA networks, which can be useful for further performance optimization.
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| 3. |
- Chen, Bolin, et al.
(författare)
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Throughput and Delay Analysis of LWA With Bursty Traffic and Randomized Flow Splitting
- 2019
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Ingår i: IEEE Access. - : IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC. - 2169-3536. ; 7, s. 24667-24678
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Tidskriftsartikel (refereegranskat)abstract
- We investigate the effect of bursty traffic in a long term evolution (LTE) and Wi-Fi aggregation (LWA)-enabled network. The LTE base station routes packets of the same IP flow through the LIE and Wi-Fi links independently. We motivate the use of superposition coding at the LWA-mode Wi-Fi access point (AP) so that it can serve LWA users and Wi-Fi users simultaneously. A random access protocol is applied in such system, which allows the native-mode AP to access the channel with probabilities that depend on the queue size of the LWA-mode AP to avoid impeding the performance of the LWA-enabled network. We analyze the throughput of the native Wi-Fi network and the delay experienced by the LWA users, accounting for the native-mode AP access probability, the traffic flow splitting between LTE and Wi-Fi, and the operating mode of the LWA user with both LIE and Wi-Fi interfaces. Our results show some fundamental tradeoffs in the throughput and delay behavior of LWA-enabled networks, which provide meaningful insight into the operation of such aggregated systems.
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| 4. |
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| 5. |
- Bolin, Sara, 1988-, et al.
(författare)
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Dormant SOX9-positive cells behind MYC-driven medulloblastoma recurrence
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Tidskriftsartikel (refereegranskat)abstract
- Tumor recurrence is a slow biological process involving therapy resistance, immune escape, and metastasis and is the leading cause of death in medulloblastoma, the most frequent malignant pediatric brain tumor. By studying paired primary-recurrent patient samples and patient-derived xenografts we identified a significant accumulation of SOX9-positive cells in relapses and metastases. They exist as rare, quiescent cells in Group 3 and Group 4 patients that constitute two-thirds of medulloblastoma. To follow relapse at the single-cell level we developed an inducible dual Tet model of MYC-driven MB, where MYC can be directed from treatment-sensitive bulk cells to resistant, dormant SOX9-positive cells by doxycycline. SOX9 promoted immune es-cape, DNA repair suppression and was essential for recurrence. Tumor cell dormancy was non-hierarchical, migratory, and depended on MYC suppression by SOX9 to promote relapse. By using computational modeling and treatment we further showed how doxorubicin and MGMT inhibitors are specifically targeting relapsing cells.
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| 6. |
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| 7. |
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| 8. |
- Borgenvik, Anna, 1987-, et al.
(författare)
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Dormant SOX9-Positive Cells Facilitate MYC-Driven Recurrence of Medulloblastoma
- 2022
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Ingår i: Cancer Research. - : AMER ASSOC CANCER RESEARCH. - 0008-5472 .- 1538-7445. ; 82:24, s. 4586-4603
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Tidskriftsartikel (refereegranskat)abstract
- Relapse is the leading cause of death in patients with medulloblas-toma, the most common malignant pediatric brain tumor. A better understanding of the mechanisms underlying recurrence could lead to more effective therapies for targeting tumor relapses. Here, we observed that SOX9, a transcription factor and stem cell/glial fate marker, is limited to rare, quiescent cells in high-risk medulloblastoma with MYC amplification. In paired primary-recurrent patient samples, SOX9-positive cells accumulated in medulloblastoma relapses. SOX9 expression anti-correlated with MYC expression in murine and human medulloblastoma cells. However, SOX9-positive cells were plastic and could give rise to a MYC high state. To follow relapse at the single-cell level, an inducible dual Tet model of medulloblastoma was developed, in which MYC expression was redirected in vivo from treatment-sensitive bulk cells to dormant SOX9-positive cells using doxycycline treatment. SOX9 was essential for relapse initiation and depended on suppression of MYC activity to promote therapy resistance, epithelial-mesenchymal transition, and immune escape. p53 and DNA repair pathways were downregulated in recurrent tumors, whereas MGMT was upregulated. Recurrent tumor cells were found to be sensitive to treatment with an MGMT inhibitor and doxorubicin. These findings suggest that recurrence-specific targeting coupled with DNA repair inhibition comprises a potential therapeutic strategy in patients affected by medulloblastoma relapse.Significance: SOX9 facilitates therapy escape and recurrence in medulloblastoma via temporal inhibition of MYC/MYCN genes, revealing a strategy to specifically target SOX9-positive cells to prevent tumor relapse.
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| 9. |
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| 10. |
- Chen, Bolin, et al.
(författare)
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Resource Optimization for Joint LWA and LTE-U in Load-Coupled and Multi-Cell Networks
- 2019
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Ingår i: IEEE Communications Letters. - : IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC. - 1089-7798 .- 1558-2558. ; 23:2, s. 330-333
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Tidskriftsartikel (refereegranskat)abstract
- We consider the performance optimization of multi-cell networks with LTE and Wi-Fi aggregation (LWA) and LTE-unlicensed (LTE-U) with sharing of the unlicensed band. Theoretical results are derived to enable an algorithm to approach the optimum. Numerical results show the algorithm's effectiveness and benefits of joint use of LWA and LTE-U.
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