| 1. |
|
|
| 2. |
|
|
| 3. |
- Baenas, Isabel, et al.
(författare)
-
Impact of COVID-19 Lockdown in Eating Disorders : A Multicentre Collaborative International Study
- 2022
-
Ingår i: Nutrients. - : MDPI AG. - 2072-6643. ; 14:1
-
Tidskriftsartikel (refereegranskat)abstract
- Background. The COVID-19 lockdown has had a significant impact on mental health. Patients with eating disorders (ED) have been particularly vulnerable. Aims. (1) To explore changes in eating-related symptoms and general psychopathology during lockdown in patients with an ED from various European and Asian countries; and (2) to assess differences related to diagnostic ED subtypes, age, and geography. Methods. The sample comprised 829 participants, diagnosed with an ED according to DSM-5 criteria from specialized ED units in Europe and Asia. Participants were assessed using the COVID-19 Isolation Scale (CIES). Results. Patients with binge eating disorder (BED) experienced the highest impact on weight and ED symptoms in comparison with other ED subtypes during lockdown, whereas individuals with other specified feeding and eating disorders (OFSED) had greater deterioration in general psychological functioning than subjects with other ED subtypes. Finally, Asian and younger individuals appeared to be more resilient. Conclusions. The psychopathological changes in ED patients during the COVID-19 lockdown varied by cultural context and individual variation in age and ED diagnosis. Clinical services may need to target preventive measures and adapt therapeutic approaches for the most vulnerable patients.
|
|
| 4. |
- Chen, Jue, et al.
(författare)
-
Mechanism of oxidative inactivation of human presequence protease by hydrogen peroxide
- 2014
-
Ingår i: Free Radical Biology & Medicine. - : Elsevier BV. - 0891-5849 .- 1873-4596. ; 77, s. 57-63
-
Tidskriftsartikel (refereegranskat)abstract
- The mitochondrial presequence protease (PreP) is a member of the pitrilysin class of metalloproteases. It degrades the mitochondrial targeting presequences of mitochondria-localized proteins as well as unstructured peptides such as amyloid-beta peptide. The specific activity of PreP is reduced in Alzheimer patients and animal models of Alzheimer disease. The loss of activity can be mimicked in vitro by exposure to oxidizing conditions, and indirect evidence suggested that inactivation was due to methionine oxidation. We performed peptide mapping analyses to elucidate the mechanism of inactivation. None of the 24 methionine residues in recombinant human PreP was oxidized. We present evidence that inactivation is due to oxidation of cysteine residues and consequent oligomerization through intermolecular disulfide bonds. The most susceptible cysteine residues to oxidation are Cys34, Cys112, and Cys119. Most, but not all, of the activity loss is restored by the reducing agent dithiothreitol. These findings elucidate a redox mechanism for regulation of PreP and also provide a rational basis for therapeutic intervention in conditions characterized by excessive oxidation of PreP.
|
|
| 5. |
- Fernández-Aranda, Fernando, et al.
(författare)
-
COVID Isolation Eating Scale (CIES) : Analysis of the impact of confinement in eating disorders and obesity—A collaborative international study
- 2020
-
Ingår i: European Eating Disorders Review. - : Wiley. - 1072-4133 .- 1099-0968. ; 28:6, s. 871-883
-
Tidskriftsartikel (refereegranskat)abstract
- Confinement during the COVID-19 pandemic is expected to have a serious and complex impact on the mental health of patients with an eating disorder (ED) and of patients with obesity. The present manuscript has the following aims: (1) to analyse the psychometric properties of the COVID Isolation Eating Scale (CIES), (2) to explore changes that occurred due to confinement in eating symptomatology; and (3) to explore the general acceptation of the use of telemedicine during confinement. The sample comprised 121 participants (87 ED patients and 34 patients with obesity) recruited from six different centres. Confirmatory Factor Analyses (CFA) tested the rational-theoretical structure of the CIES. Adequate goodness-of-fit was obtained for the confirmatory factor analysis, and Cronbach alpha values ranged from good to excellent. Regarding the effects of confinement, positive and negative impacts of the confinement depends of the eating disorder subtype. Patients with anorexia nervosa (AN) and with obesity endorsed a positive response to treatment during confinement, no significant changes were found in bulimia nervosa (BN) patients, whereas Other Specified Feeding or Eating Disorder (OSFED) patients endorsed an increase in eating symptomatology and in psychopathology. Furthermore, AN patients expressed the greatest dissatisfaction and accommodation difficulty with remote therapy when compared with the previously provided face-to-face therapy. The present study provides empirical evidence on the psychometric robustness of the CIES tool and shows that a negative confinement impact was associated with ED subtype, whereas OSFED patients showed the highest impairment in eating symptomatology and in psychopathology.
|
|
| 6. |
- Shen, Jue, et al.
(författare)
-
Phase noise improvement and noise modeling of type-I ADPLL with non-linear quantization effects
- 2015
-
Ingår i: NORCHIP 2014 - 32nd NORCHIP Conference. - : IEEE conference proceedings. - 9781479954421
-
Konferensbidrag (refereegranskat)abstract
- This paper presents a phase noise improvement method for fine tuning of type-I ADPLL by exploiting its nonlinear quantization effects. When quantization step approaches the same orders of magnitude of standard deviation of input noise, quantization effects become nonlinear, and additive noise modeling of quantization effects is no longer applicable. By proper offsetting the input signals in this case, the feedback loop of ADPLL can be very sensitive to frequency phase deviation. It results in a larger loop bandwidth, and in turn smaller in-band phase noise than in linear quantization case. A theoretic s-domain noise model is proposed to quantify the phase noise in nonlinear case. Results are verified in Modelsim simulations. Proposed method offers possibility of achieving lower phase noise by lower quantization resolution and less circuit design efforts.
|
|
| 7. |
- Shen, Zhongjin, et al.
(författare)
-
Synthesis and Photovoltaic Properties of Powerful Electron-Donating Indeno[1, 2-b]thiophene-Based Green D-A-pi-A Sensitizers for Dye-Sensitized Solar Cells
- 2016
-
Ingår i: ACS Sustainable Chemistry and Engineering. - : American Chemical Society (ACS). - 2168-0485. ; 4:6, s. 3518-3525
-
Tidskriftsartikel (refereegranskat)abstract
- Three new near-infrared D-A-pi-A dyes (Si, S2, and S3) with 80 indeno[1,2-b]thiophene-based strong donor, containing 5,6-difluorobenzo[c][1,2,5]thiadiazole (DFBT), benzo[c][1,2,5]thiadiazole (BT), and 2,3diphenylpyrido[3,4-b]pyrazine (PP) as the auxiliary acceptor, respectively, were synthesized for the application of dye-sensitized solar cells. Introduction of powerful electron-donating unit of indeno[1,2-b]thiophene and the strong electron-withdrawing DFBT, BT, and PP groups into the conjugation bridge can enhance the absorption wavelength range into NIR region, where the maximum absorptions of the three compounds are all over 610 nm and S3 can reach 628 nm. Moreover, it is rare to see that the colors of the dyes are all green both in dichloromethane and on the TiO2 film. Via fine-tuning of the auxiliary moiety, the onset of incident-photon-conversion efficiency of S1-S3 can reach 850 nm and S3-based DSSCs in the presence of iodine and cobalt electrolytes show the best overall solar energy conversion efficiency of 6.29% and 7.23% under full sunlight (AM 1.5G, 100 mW cm(-2)) irradiation, which are relatively high values in organic NIR green dye-based DSSCs. Electrochemical impedance spectroscopy indicates that S3-based DSSCs can suppress charge recombination more efficiently, accounting for its higher open circuit voltage and short circuit current.
|
|
| 8. |
- Wang, Kun
(författare)
-
Migration Towards Next Generation Optical Access and Transport Networks
- 2017
-
Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- By 2020 there will be 50 billion connected devices over the Internet. With the fast-increasing data traffic demand in both fixed and mobile networks, network operators need to migrate networks towards next generation solutions. The network migration requires the enormous investment in equipment and infrastructure, while the revenues are not expected to grow significantly. Therefore, one of the main challenges for network operators is to find out a proper cost-effective optical network solution that can match future high capacity demand and flexibly support multiple network services on a common network infrastructure.The first part of the thesis addresses the Active Optical Network (AON) and its migration strategies towards Next Generation Optical Access (NGOA) solutions. Several migration strategies are proposed from the perspective of network topology, data plane and control plane. A general methodology for Techno-Economic analysis has been developed and applied to the Total Cost of Ownership (TCO) calculation of different NGOA solutions. The thesis provides a complete cost evaluation of AON migration paths, which can be used by network operators to assess the economic feasibility of network migration.A converged Optical Transport Network (OTN) that can serve both fixed and mobile network services is beneficial from the cost-saving perspective. However, the different types of services, require different network performance. The second part of the thesis focuses on the investigation of the converged OTN that can be flexibly and timely adjusted to satisfy varying service conditions. A programmable OTN featured with Wavelength Division Multiplexing (WDM) in the data plane and Software Defined Networking (SDN) in control plane has been proposed. To demonstrate the benefits of the converged OTN, the thesis also provides a multi-domain orchestration architecture for the multiple network services. The resource orchestration, across three network domains: OTN, mobile network and cloud, enables agile service creation and optimized resource allocation among the multiple domains.
|
|
| 9. |
- Zhou, Ying, et al.
(författare)
-
The Effect of Pyridyl Nitrogen Atom Position in Pyrido-[3,4-b]pyrazines in Donor-Acceptor-pi-Acceptor Dyes on Absorption, Energy Levels, and Photovoltaic Performances of Dye-Sensitized Solar Cells
- 2016
-
Ingår i: ASIAN JOURNAL OF ORGANIC CHEMISTRY. - : Wiley-Blackwell. - 2193-5807. ; 5:2, s. 293-300
-
Tidskriftsartikel (refereegranskat)abstract
- A donor-acceptor-pi-acceptor (D-A-pi-A)-type organic dye (DTN-1) incorporating a pyrido[3,4-b]pyrazine (PP) unit with the pyridyl N atom adjacent to the anchoring group has been synthesized for use in dye-sensitized solar cells (DSSCs). The maximum absorption wavelength of DTN-1 was clearly red-shifted compared with dye DT-1, based on PP unit with the pyridyl N atom adjacent to the donor group. However, this change of structure has a negative effect on photovoltaic performances, and devices made with DTN-1 only reached a power conversion efficiency of 6.10% under AM1.5G irradiation compared with 8.57% achieved by DT-1. Density functional theory calculations suggest that DTN-1 has a smaller oscillator strength, which is connected to its relatively low light-harvesting efficiency. In addition, the results of electrochemical impedance spectroscopy (EIS) reveal that charge recombination in DSSCs based on DTN-1 is more than that in the counterpart DT-1, thus leading to a lower open-circuit voltage (V-oc).
|
|
