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Sökning: WFRF:(Chen Xianwen)

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1.
  • Deng, Min, et al. (författare)
  • Genome-wide association analyses in Han Chinese identify two new susceptibility loci for amyotrophic lateral sclerosis
  • 2013
  • Ingår i: Nature Genetics. - : Nature Publishing Group. - 1061-4036 .- 1546-1718. ; 45:6, s. 697-
  • Tidskriftsartikel (refereegranskat)abstract
    • To identify susceptibility genes for amyotrophic lateral sclerosis (ALS), we conducted a genome-wide association study (GWAS) in 506 individuals with sporadic ALS and 1,859 controls of Han Chinese ancestry. Ninety top SNPs suggested by the current GWAS and 6 SNPs identified by previous GWAS were analyzed in an independent cohort of 706 individuals with ALS and 1,777 controls of Han Chinese ancestry. We discovered two new susceptibility loci for ALS at 1q32 (CAMK1G, rs6703183, P-combined = 2.92 x 10(-8), odds ratio (OR) = 1.31) and 22p11 (CABIN1 and SUSD2, rs8141797, P-combined = 2.35 x 10(-9), OR = 1.52). These two loci explain 12.48% of the overall variance in disease risk in the Han Chinese population. We found no association evidence for the previously reported loci in the Han Chinese population, suggesting genetic heterogeneity of disease susceptibility for ALS between ancestry groups. Our study identifies two new susceptibility loci and suggests new pathogenic mechanisms of ALS.
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2.
  • Łaszkiewicz, Edyta, et al. (författare)
  • Valuing access to urban greenspace using non-linear distance decay in hedonic property pricing
  • 2022
  • Ingår i: Ecosystem Services. - : Elsevier BV. - 2212-0416. ; 53
  • Tidskriftsartikel (refereegranskat)abstract
    • Modelling walking distance enables the observation of non-linearities in hedonic property pricing of accessibility to greenspace. We test a penalized spline spatial error model (PS-SEM), which has two distinctive features. First, the PS-SEM controls for the presence of a spatially autocorrelated error term. Second, the PS-SEM allows for continuous non-linear distance decay of the property price premium as a function of walking distance to greenspaces. As a result, compared with traditional spatial econometric methods, the PS-SEM has the advantage that data determines the functional form of the distance decay of the implicit price for greenspace accessibility. Our PS-SEM results from Oslo, Norway, suggest that the implicit price for greenspace access is highly non-linear in walking distance, with the functional form varying for different types of greenspaces. Our results caution against using simple linear distances and assumptions of log or stepwise buffer-based distance decay in property prices relative to pedestrian network distance to urban amenities. The observed heterogeneity in the implicit property prices for walking distance to greenspace also provides a general caution against using non-spatial hedonic pricing models when aggregating values of greenspace amenities for policy analysis or urban ecosystem accounting purposes.
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