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- Hudson, Thomas J., et al.
(author)
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International network of cancer genome projects
- 2010
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In: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 464:7291, s. 993-998
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Journal article (peer-reviewed)abstract
- The International Cancer Genome Consortium (ICGC) was launched to coordinate large-scale cancer genome studies in tumours from 50 different cancer types and/or subtypes that are of clinical and societal importance across the globe. Systematic studies of more than 25,000 cancer genomes at the genomic, epigenomic and transcriptomic levels will reveal the repertoire of oncogenic mutations, uncover traces of the mutagenic influences, define clinically relevant subtypes for prognosis and therapeutic management, and enable the development of new cancer therapies.
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| 3. |
- Liu, Meng, 1976, et al.
(author)
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Targeting the protein prenyltransferases efficiently reduces tumor development in mice with K-RAS-induced lung cancer
- 2010
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In: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 0027-8424. ; 107:14, s. 6471-6476
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Journal article (peer-reviewed)abstract
- RAS and RHO proteins, which contribute to tumorigenesis and metastasis, undergo posttranslational modification with an isoprenyl lipid by protein farnesyltransferase (FTase) or protein geranylgeranyltransferase-I (GGTase-I). Inhibitors of FTase and GGTase-I were developed to block RAS-induced malignancies, but their utility has been difficult to evaluate because of off-target effects, drug resistance, and toxicity. Moreover, the impact of FTase deficiency and combined FTase/GGTase-I deficiency has not been evaluated with genetic approaches. We found that inactivation of FTase eliminated farnesylation of HDJ2 and H-RAS, prevented H-RAS targeting to the plasma membrane, and blocked proliferation of primary and K-RAS(G12D)-expressing fibroblasts. FTase inactivation in mice with K-RAS-induced lung cancer reduced tumor growth and improved survival, similar to results obtained previously with inactivation of GGTase-I. Simultaneous inactivation of FTase and GGTase-I markedly reduced lung tumors and improved survival without apparent pulmonary toxicity. These data shed light on the biochemical and therapeutic importance of FTase and suggest that simultaneous inhibition of FTase and GGTase-I could be useful in cancer therapeutics.
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| 4. |
- Qin, Chunxia, et al.
(author)
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An oral and maxillofacial navigation system for implant placement with automatic identification of fiducial points
- 2019
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In: International Journal of Computer Assisted Radiology and Surgery. - : SPRINGER HEIDELBERG. - 1861-6410 .- 1861-6429. ; 14:2, s. 281-289
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Journal article (peer-reviewed)abstract
- PurposeSurgical navigation system (SNS) has been an important tool in surgery. However, the complicated and tedious manual selection of fiducial points on preoperative images for registration affects operational efficiency to large extent. In this study, an oral and maxillofacial navigation system named BeiDou-SNS with automatic identification of fiducial points was developed and demonstrated.MethodsTo solve the fiducial selection problem, a novel method of automatic localization for titanium screw markers in preoperative images is proposed on the basis of a sequence of two local mean-shift segmentation including removal of metal artifacts. The operation of the BeiDou-SNS consists of the following key steps: The selection of fiducial points, the calibration of surgical instruments, and the registration of patient space and image space. Eight cases of patients with titanium screws as fiducial markers were carried out to analyze the accuracy of the automatic fiducial point localization algorithm. Finally, a complete phantom experiment of zygomatic implant placement surgery was performed to evaluate the whole performance of BeiDou-SNS. Results and conclusionThe coverage of Euclidean distances between fiducial marker positions selected automatically and those selected manually by an experienced dentist for all eight cases ranged from 0.373 to 0.847mm. Four implants were inserted into the 3D-printed model under the guide of BeiDou-SNS. And the maximal deviations between the actual and planned implant were 1.328mm and 2.326mm, respectively, for the entry and end point while the angular deviation ranged from 1.094 degrees to 2.395 degrees. The results demonstrate that the oral surgical navigation system with automatic identification of fiducial points can meet the requirements of the clinical surgeries.
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- Wang, Chengliang, et al.
(author)
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Hybrid-cavity fabry-perot interferometer for multi-point relative humidity and temperature sensing
- 2018
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In: Sensors and actuators. B, Chemical. - : Elsevier BV. - 0925-4005 .- 1873-3077. ; 255, s. 1937-1944
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Journal article (peer-reviewed)abstract
- A novel hybrid-cavity Fabry-Perot interferometer (HFPI) is theoretically proposed and experimentally demonstrated. The hybrid micro-cavity structure is consisted of a short segment of four-hole suspended-core fiber (SCF) and attaching moderate optical adhesive as the hygroscopic material. Due to the different sensitivities of the hybrid Fabry-Perot (F-P) cavities to the relative humidity (RH) and temperature, both information can be simultaneously demodulated by utilizing the phase-shift tracking scheme in the Fast Fourier Transform (FFT) spectra. The precise micromanipulation of each cavity length ensures the separation of each amplitude peak in the FFT spectra, which renders this HFPI multi-point sensing capability. Experimental tests were carried out, and the results indicate that the proposed HFPI with excellent sensing performance is a promising platform for multi-point RH and temperature sensing applications.
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- Wu, Shengnan, et al.
(author)
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An open-cavity Fabry-Perot interferometer with PVA coating for simultaneous measurement of relative humidity and temperature
- 2016
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In: Sensors and actuators. B, Chemical. - : ELSEVIER SCIENCE SA. - 0925-4005 .- 1873-3077. ; 225, s. 50-56
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Journal article (peer-reviewed)abstract
- A fiber-optic open-cavity Fabry-Perot (FP) interferometer (FPI) with polyvinyl alcohol (PVA) coating is proposed and experimentally demonstrated for simultaneous measurement of relative humidity (RH) and temperature. The FPI consists of an etched side-hole fiber (SHF) sandwiched in between two leading single-mode-fibers. The PVA film is plated on the fiber surface functioning as a humidity-to-refractive index (RI) transducer. Theoretical analysis details the RH and temperature influence on the spectral fringes of the FPI. Experimental results confirms and show that, the reflection loss of the FPI nonlinearly decreases more than 15 dB when the RH increases from 30%RH to 90%RH with a highest sensitivity of -1.2 dB/%RH, while the dip wavelength of the spectral fringe exhibits linear RH and temperature sensitivities of -23.1 pm/%RH and -6.14 pm/degrees C, respectively. Thus, by monitoring the reflection and wavelength of the interference dip, the proposed sensor enables accurate simultaneous measurement of RH and temperature. A fast and reversible time response has also been demonstrated. Such excellent sensing performance with compactness, ease of fabrication makes our sensing structure a highly promising candidate for RH and temperature monitoring applications.
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| 7. |
- Zhou, Huimin, et al.
(author)
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Relative importance of climatic variables, soil properties and plant traits to spatial variability in net CO2 exchange across global forests and grasslands
- 2021
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In: Agricultural and Forest Meteorology. - : Elsevier BV. - 0168-1923. ; 307
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Journal article (peer-reviewed)abstract
- Compared to the well-known drivers of spatial variability in gross primary productivity (GPP), the relative importance of climatic variables, soil properties and plant traits to the spatial variability in net ecosystem exchange of CO2 between terrestrial ecosystem and atmosphere (NEE) is poorly understood. We used principal component regression to analyze data from 147 eddy flux sites to disentangle effects of climatic variables, soil properties and plant traits on the spatial variation in annual NEE and its components (GPP and ecosystem respiration (RE)) across global forests and grasslands. Our results showed that the largest unique contribution (proportion of variance only explained by one class of variables) to NEE variance came from climatic variables for forests (24%-30%) and soil properties for grasslands (41%-54%). Specifically, mean annual precipitation and potential evapotranspiration were the most important climatic variables driving forest NEE, whereas available soil water capacity, clay content and cation exchange capacity mainly influenced grassland NEE. Plant traits showed a small unique contribution to NEE in both forests and grasslands. However, leaf phosphorus content strongly interacted with soil total nitrogen density and clay content, and these combined factors represented a major contribution for grassland NEE. For GPP and RE, the majority of spatial variance was attributed to the common contribution of climate, soil and plant traits (50% - 62%, proportion of variance explained by more than one class of variables), rather than their unique contributions. Interestingly, those factors with only minor influences on GPP and RE variability (e.g., soil properties) have significant contributions to the spatial variability in NEE. Such emerging factors and the interactions between climatic variables, soil properties and plant traits are not well represented in current terrestrial biosphere models, which should be considered in future model improvement to accurately predict the spatial pattern of carbon cycling across forests and grasslands globally.
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