| 1. |
- Morris, David L, et al.
(författare)
-
Genome-wide association meta-analysis in Chinese and European individuals identifies ten new loci associated with systemic lupus erythematosus
- 2016
-
Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 48:8
-
Tidskriftsartikel (refereegranskat)abstract
- Systemic lupus erythematosus (SLE; OMIM 152700) is a genetically complex autoimmune disease. Genome-wide association studies (GWASs) have identified more than 50 loci as robustly associated with the disease in single ancestries, but genome-wide transancestral studies have not been conducted. We combined three GWAS data sets from Chinese (1,659 cases and 3,398 controls) and European (4,036 cases and 6,959 controls) populations. A meta-analysis of these studies showed that over half of the published SLE genetic associations are present in both populations. A replication study in Chinese (3,043 cases and 5,074 controls) and European (2,643 cases and 9,032 controls) subjects found ten previously unreported SLE loci. Our study provides further evidence that the majority of genetic risk polymorphisms for SLE are contained within the same regions across both populations. Furthermore, a comparison of risk allele frequencies and genetic risk scores suggested that the increased prevalence of SLE in non-Europeans (including Asians) has a genetic basis.
|
|
| 2. |
- Liu, Tanghong, et al.
(författare)
-
Reasonable pressure tap layout to measure the aerodynamic forces of a train at different yaw angles
- 2020
-
Ingår i: Measurement: Journal of the International Measurement Confederation. - : Elsevier BV. - 0263-2241. ; 166
-
Tidskriftsartikel (refereegranskat)abstract
- The present work studies the aerodynamic loads of a train for different yaw angles from 5.87 degrees to 30 degrees by using the detached-eddy simulation (DES) method. Furthermore, based on the pressure integral method, a reasonable layout of the pressure taps on the train under a crosswind is studied to obtain the aerodynamic forces and moments that are used for a comparison with the results of the wind tunnel test. Considering the lower errors of the pressure integral results and fewer number of pressure taps comprehensively, the pressure integral method in the case of 15-4 (15 represents the tap quantity along the length direction, 4 represents the tap quantity along the height/width direction) on the head car and tail car, the case of 14-4 on the middle car are relatively good among the nine cases discussed in this paper. Compared to the results of the wind tunnel test, for the head car, the maximum error of the side force coefficient (C-y), rolling moment coefficient (M-x), and yawing moment coefficient (M-z) is all less than 10% for yaw angles from 5.87 degrees to 90 degrees, and the maximum errors of lift force coefficient (C-z) is less than 20% for yaw angles from 10.2 degrees to 90'; for the middle car, the maximum error of C-y is less than 20% for yaw angles from 5.87 degrees to 90 degrees, and the maximum error of C-z, M-x and M-z is all less than 15% for yaw angles from 5.87 degrees to 90'; for the tail car, the maximum error of C-y, C-z, M-x and M-z is all less than 15% for yaw angles from 10.2 degrees to 90 degrees. (C) 2020 Elsevier Ltd. All rights reserved.
|
|
| 3. |
- Niu, Jiqiang, et al.
(författare)
-
Investigation of aerodynamic behaviour of a high-speed train on different railway infrastructure scenarios under crosswind
- 2022
-
Ingår i: Wind and Structures, An International Journal. - 1598-6225 .- 1226-6116. ; 35:6, s. 405-418
-
Tidskriftsartikel (refereegranskat)abstract
- The aerodynamic behaviour of a CRH high-speed train under three infrastructure scenarios (flat ground, embankment, and viaduct) in the presence of a crosswind was simulated using a 1/8th scaled train model with three cars and the IDDES framework. The time-averaged and instantaneous flow field around the model were examined. The employed numerical algorithm was verified through a wind tunnel test, and the grid and timestep resolution analyses were conducted to ensure the reliability of the data. It was noted that the flow around the rail line was different under different infrastructure scenarios, especially in the case of the embankment, which degraded the aerodynamic performance of the train under the crosswind. The flow around the train on the flat ground and viaduct was different, although the aerodynamic performance of the train was similar in both cases. Moreover, the viaduct accidents were noted to have the most critical consequences, thereby requiring the most attention. The aerodynamic performance of the train on the windward track of the embankment under the crosswind was worse than that of the train on the leeward track. But for the other two infrastructure scenarios, the aerodynamic performance of the train on the windward track is relatively dangerous, which is mainly caused by the head car. These observations suggest that the aerodynamic behaviour of the train on an embankment under a crosswind must be carefully considered and that certain wind protection measures must be adopted around rail lines in windy areas.
|
|
| 4. |
|
|
