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| 3. |
- Block, Keith I., et al.
(författare)
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Designing a broad-spectrum integrative approach for cancer prevention and treatment
- 2015
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Ingår i: Seminars in Cancer Biology. - : Academic Press. - 1044-579X .- 1096-3650. ; 35, s. S276-S304
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Forskningsöversikt (refereegranskat)abstract
- Targeted therapies and the consequent adoption of "personalized" oncology have achieved notable successes in some cancers; however, significant problems remain with this approach. Many targeted therapies are highly toxic, costs are extremely high, and most patients experience relapse after a few disease-free months. Relapses arise from genetic heterogeneity in tumors, which harbor therapy-resistant immortalized cells that have adopted alternate and compensatory pathways (i.e., pathways that are not reliant upon the same mechanisms as those which have been targeted). To address these limitations, an international task force of 180 scientists was assembled to explore the concept of a low-toxicity "broadspectrum" therapeutic approach that could simultaneously target many key pathways and mechanisms. Using cancer hallmark phenotypes and the tumor microenvironment to account for the various aspects of relevant cancer biology, interdisciplinary teams reviewed each hallmark area and nominated a wide range of high-priority targets (74 in total) that could be modified to improve patient outcomes. For these targets, corresponding low-toxicity therapeutic approaches were then suggested, many of which were phytochemicals. Proposed actions on each target and all of the approaches were further reviewed for known effects on other hallmark areas and the tumor microenvironment Potential contrary or procarcinogenic effects were found for 3.9% of the relationships between targets and hallmarks, and mixed evidence of complementary and contrary relationships was found for 7.1%. Approximately 67% of the relationships revealed potentially complementary effects, and the remainder had no known relationship. Among the approaches, 1.1% had contrary, 2.8% had mixed and 62.1% had complementary relationships. These results suggest that a broad-spectrum approach should be feasible from a safety standpoint. This novel approach has potential to be relatively inexpensive, it should help us address stages and types of cancer that lack conventional treatment, and it may reduce relapse risks. A proposed agenda for future research is offered. (C) 2015 The Authors. Published by Elsevier Ltd.
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| 4. |
- Bai, Fan, et al.
(författare)
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Application of similarity theory in modeling the output characteristics of proton exchange membrane fuel cell
- 2021
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Ingår i: International journal of hydrogen energy. - : PERGAMON-ELSEVIER SCIENCE LTD. - 0360-3199 .- 1879-3487. ; 46:74, s. 36940-36953
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Tidskriftsartikel (refereegranskat)abstract
- Proton Exchange Membrane Fuel Cell (PEMFC) has attracted widespread interest. In the present work, similarity analysis is adopted for a three-dimensional single-phase isothermal model of PEMFC to derive similarity criteria. Seven kinds of input criteria (Pi(1) similar to Pi(7)) are obtained, relevant to the fluid flow, pressure drop, flow resistance in a porous medium, activity loss, diffusion mass transfer, convective mass transfer and ohmic loss in PEMFC respectively. Dimensionless voltage and dimensionless current density are defined as two output criteria. Numerical verifications show that if the seven criteria keep their individual values with their components vary in a wide range, the dimensionless polarization curves keep the same with a deviation about 1%, showing the validity and feasibility of the present analysis. From the effect on the dimensionless polarization curve, sensibility analysis shows that the seven criteria can be divided into three categories: strong (Pi(4) and Pi(7), -94.9% similar to +349.2%), mild to minor (Pi(5) and Pi(6), -4.5% similar to +5.0%), and negligible (Pi(1), Pi(2) and Pi(3), -1.2% similar to +1.1%). The similarity analysis approach can greatly save computation time in modeling the output characteristics of PEMFC. (C) 2021 Published by Elsevier Ltd on behalf of Hydrogen Energy Publications LLC.
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| 5. |
- Ma, Tao, et al.
(författare)
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Genomic insights into salt adaptation in a desert poplar
- 2013
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Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 4, s. 2797-
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Tidskriftsartikel (refereegranskat)abstract
- Despite the high economic and ecological importance of forests, our knowledge of the genomic evolution of trees under salt stress remains very limited. Here we report the genome sequence of the desert poplar, Populus euphratica, which exhibits high tolerance to salt stress. Its genome is very similar and collinear to that of the closely related mesophytic congener, P. trichocarpa. However, we find that several gene families likely to be involved in tolerance to salt stress contain significantly more gene copies within the P. euphratica lineage. Furthermore, genes showing evidence of positive selection are significantly enriched in functional categories related to salt stress. Some of these genes, and others within the same categories, are significantly upregulated under salt stress relative to their expression in another salt-sensitive poplar. Our results provide an important background for understanding tree adaptation to salt stress and facilitating the genetic improvement of cultivated poplars for saline soils.
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| 6. |
- Ma, Wenjun, et al.
(författare)
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Responses of soil extracellular enzyme activities and microbial community properties to interaction between nitrogen addition and increased precipitation in a semi-arid grassland ecosystem
- 2020
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Ingår i: Science of the Total Environment. - : Elsevier BV. - 0048-9697. ; 703
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Tidskriftsartikel (refereegranskat)abstract
- Both atmospheric nitrogen (N) deposition and precipitation can strongly impact below-ground biogeochemical processes. Soil extracellular enzymes activities (EEAs) and microorganisms are considered as the key agents in ecosystem nutrient cycling. However, how the interaction between increasing N deposition and precipitation may affect soil EEAs and microbes remain poorly understood. In a 5-year field experiment in a meadow steppe in northern China, we tested the effects of N addition (N0, 0; N1, 5; N2, 10 g N m−2 yr−1) and increased precipitation (W0, ambient precipitation; W1, increase of 15% ambient precipitation; W2, increase of 30% ambient precipitation) on soil EEAs, microbial and chemical properties. Results showed that their interaction significantly affected all hydrolase activities, except for β-1,4-xylosidase (βX). Furthermore, increased precipitation and N addition interactively affected bacterial gene copies (P ≤ 0.05), and increased precipitation comparatively had a stronger effects. The results on the combination of N addition and increased precipitation showed that increased precipitation alleviated the positive effects of N addition on soil EEAs. This implies that the effects of either treatment alone on grassland biogeochemical processes may be alleviated by their simultaneous occurrence. Our results suggested that soil EEAs were mainly controlled by the content of N and phosphorus (P), and the ratio of C: N and C: P. Therefore, soil element content and stoichiometry could better explain the responses of EEAs to global changes. Moreover, soil microbial communities were mainly controlled by soil P content. Overall, our study highlights that the interaction between N deposition and precipitation may play a vital role in predicting the responses of soil enzyme activities to global changes in grassland ecosystems.
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| 7. |
- Menkveld, Albert J., et al.
(författare)
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Nonstandard Errors
- 2024
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Ingår i: JOURNAL OF FINANCE. - : Wiley-Blackwell. - 0022-1082 .- 1540-6261. ; 79:3, s. 2339-2390
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Tidskriftsartikel (refereegranskat)abstract
- In statistics, samples are drawn from a population in a data-generating process (DGP). Standard errors measure the uncertainty in estimates of population parameters. In science, evidence is generated to test hypotheses in an evidence-generating process (EGP). We claim that EGP variation across researchers adds uncertainty-nonstandard errors (NSEs). We study NSEs by letting 164 teams test the same hypotheses on the same data. NSEs turn out to be sizable, but smaller for more reproducible or higher rated research. Adding peer-review stages reduces NSEs. We further find that this type of uncertainty is underestimated by participants.
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| 8. |
- Zhang, Zhuo, et al.
(författare)
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Demonstration of three‐dimensional indoor visible light positioning with multiple photodiodes and reinforcement learning
- 2020
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Ingår i: Sensors. - : MDPI AG. - 1424-8220. ; 20:22, s. 1-14
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Tidskriftsartikel (refereegranskat)abstract
- To provide high‐quality location‐based services in the era of the Internet of Things, visible light positioning (VLP) is considered a promising technology for indoor positioning. In this paper, we study a multi‐photodiodes (multi‐PDs) three‐dimensional (3D) indoor VLP system enhanced by reinforcement learning (RL), which can realize accurate positioning in the 3D space without any off-line training. The basic 3D positioning model is introduced, where without height information of the receiver, the initial height value is first estimated by exploring its relationship with the received signal strength (RSS), and then, the coordinates of the other two dimensions (i.e., X and Y in the horizontal plane) are calculated via trilateration based on the RSS. Two different RL processes, namely RL1 and RL2, are devised to form two methods that further improve horizontal and vertical positioning accuracy, respectively. A combination of RL1 and RL2 as the third proposed method enhances the overall 3D positioning accuracy. The positioning performance of the four presented 3D positioning methods, including the basic model without RL (i.e., Benchmark) and three RL based methods that run on top of the basic model, is evaluated experimentally. Experimental results verify that obviously higher 3D positioning accuracy is achieved by implementing any proposed RL based methods compared with the benchmark. The best performance is obtained when using the third RL based method that runs RL2 and RL1 sequentially. For the testbed that emulates a typical office environment with a height difference between the receiver and the transmitter ranging from 140 cm to 200 cm, an average 3D positioning error of 2.6 cm is reached by the best RL method, demonstrating at least 20% improvement compared to the basic model without performing RL.
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| 9. |
- Zhang, Zhuo, et al.
(författare)
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Iterative point-wise reinforcement learning for highly accurate indoor visible light positioning
- 2019
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Ingår i: Optics Express. - : OPTICAL SOC AMER. - 1094-4087 .- 1094-4087. ; 27:16, s. 22161-22172
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Tidskriftsartikel (refereegranskat)abstract
- Iterative point-wise reinforcement learning (IPWRL) is proposed for highly accurate indoor visible light positioning (VLP). By properly updating the height information in an iterative fashion, the IPWRL not only effectively mitigates the impact of non-deterministic noise but also exhibits excellent tolerance to deterministic errors caused by the inaccurate a priori height information. The principle of the IPWRL is explained, and the performance of the IPWRL is experimentally evaluated in a received signal strength (RSS) based VLP system and compared with other positioning algorithms, including the conventional RSS algorithm, the k-nearest neighbors (KNN) algorithm and the PWRL algorithm where iterations exclude. Unlike the supervised machine learning method, e.g., the KNN, whose performance is highly dependent on the training process, the proposed IPWRL does not require training and demonstrates robust positioning performance for the entire tested area. Experimental results also show that when a large height information mismatch occurs, the IPWRL is able to first correct the height information and then offers robust positioning results with a rather low positioning error, while the positioning errors caused by the other algorithms are significantly higher.
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| 10. |
- Chen, Zhuo, et al.
(författare)
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Large mechanical properties enhancement in ceramics through vacancy-mediated unit cell disturbance
- 2023
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Ingår i: Nature Communications. - : Nature Publishing Group. - 2041-1723. ; 14:1
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Tidskriftsartikel (refereegranskat)abstract
- Tailoring vacancies is a feasible way to improve the mechanical properties of ceramics. However, high concentrations of vacancies usually compromise the strength (or hardness). We show that a high elasticity and flexural strength could be achieved simultaneously using a nitride superlattice architecture with disordered anion vacancies up to 50%. Enhanced mechanical properties primarily result from a distinctive deformation mechanism in superlattice ceramics, i.e., unit-cell disturbances. Such a disturbance substantially relieves local high-stress concentration, thus enhancing deformability. No dislocation activity involved also rationalizes its high strength. The work renders a unique understanding of the deformation and strengthening/toughening mechanism in nitride ceramics.
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