| 1. |
- Castoldi, F, et al.
(författare)
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Autophagy-mediated metabolic effects of aspirin
- 2020
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Ingår i: Cell death discovery. - : Springer Science and Business Media LLC. - 2058-7716. ; 6:1, s. 129-
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Tidskriftsartikel (refereegranskat)abstract
- Salicylate, the active derivative of aspirin (acetylsalicylate), recapitulates the mode of action of caloric restriction inasmuch as it stimulates autophagy through the inhibition of the acetyltransferase activity of EP300. Here, we directly compared the metabolic effects of aspirin medication with those elicited by 48 h fasting in mice, revealing convergent alterations in the plasma and the heart metabolome. Aspirin caused a transient reduction of general protein acetylation in blood leukocytes, accompanied by the induction of autophagy. However, these effects on global protein acetylation could not be attributed to the mere inhibition of EP300, as determined by epistatic experiments and exploration of the acetyl-proteome from salicylate-treated EP300-deficient cells. Aspirin reduced high-fat diet-induced obesity, diabetes, and hepatosteatosis. These aspirin effects were observed in autophagy-competent mice but not in two different models of genetic (Atg4b−/− or Bcln1+/−) autophagy-deficiency. Aspirin also improved tumor control by immunogenic chemotherapeutics, and this effect was lost in T cell-deficient mice, as well as upon knockdown of an essential autophagy gene (Atg5) in cancer cells. Hence, the health-improving effects of aspirin depend on autophagy.
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| 2. |
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| 3. |
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| 4. |
- Baracco, EE, et al.
(författare)
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α-Ketoglutarate inhibits autophagy
- 2019
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Ingår i: Aging. - : Impact Journals, LLC. - 1945-4589. ; 11:11, s. 3418-3431
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Tidskriftsartikel (refereegranskat)
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| 5. |
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| 6. |
- Nilforoushan, Faramarz, et al.
(författare)
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GPS network monitors the Arabia-Eurasia collision deformation in Iran
- 2003
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Ingår i: Journal of Geodesy. - : Springer Science and Business Media LLC. - 0949-7714 .- 1432-1394. ; 77, s. 411-422
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Tidskriftsartikel (refereegranskat)abstract
- The rate of crustal deformation in Iran due to the Arabia–Eurasia collision is estimated. The results are based on new global positioning system (GPS) data. In order to address the problem of the distribution of the deformation in Iran, Iranian and French research organizations have carried out the first large-scale GPS survey of Iran. A GPS network of 28 sites (25 in Iran, two in Oman and one in Uzbekistan) has been installed and surveyed twice, in September 1999 and October 2001. Each site has been surveyed for a minimum observation of 4 days. GPS data processing has been done using the GAMIT-GLOBK software package. The solution displays horizontal repeatabilities of about 1.2 mm in 1999 and 2001. The resulting velocities allow us to constrain the kinematics of the Iranian tectonic blocks. These velocities are given in ITRF2000 and also relative to Eurasia. This last kinematic model demonstrates that (1) the north–south shortening from Arabia to Eurasia is 2–2.5 cm/year, less than previously estimated, and (2) the transition from subduction (Makran) to collision (Zagros) is very sharp and governs the different styles of deformation observed in Iran. In the eastern part of Iran, most of the shortening is accommodated in the Gulf of Oman, while in the western part the shortening is more distributed from south to north. The large faults surrounding the Lut block accommodate most of the subduction–collision transition.
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| 7. |
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| 8. |
- Vernant, P, et al.
(författare)
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Present-day crustal deformation and plate kinematics in the Middle East constrained by GPS measurements in Iran and northern Oman
- 2004
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Ingår i: Geophysical Journal International. - 0956-540X .- 1365-246X. ; 157:1, s. 381-398
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Tidskriftsartikel (refereegranskat)abstract
- A network of 27 GPS sites was implemented in Iran and northern Oman to measure displacements in this part of the Alpine–Himalayan mountain belt. We present and interpret the results of two surveys performed in 1999 September and 2001 October. GPS sites in Oman show northward motion of the Arabian Plate relative to Eurasia slower than the NUVEL-1A estimates (e.g. 22 ± 2 mm yr−1 at N8°± 5°E instead of 30.5 mm yr−1 at N6°E at Bahrain longitude). We define a GPS Arabia–Eurasia Euler vector of 27.9°± 0.5°N, 19.5°± 1.4°E, 0.41°± 0.1° Myr−1. The Arabia–Eurasia convergence is accommodated differently in eastern and western Iran. East of 58°E, most of the shortening is accommodated by the Makran subduction zone (19.5 ± 2 mm yr−1) and less by the Kopet-Dag (6.5 ± 2 mm yr−1). West of 58°E, the deformation is distributed in separate fold and thrust belts. At the longitude of Tehran, the Zagros and the Alborz mountain ranges accommodate 6.5 ± 2 mm yr−1 and 8 ± 2 mm yr−1 respectively. The right-lateral displacement along the Main Recent Fault in the northern Zagros is about 3 ± 2 mm yr−1, smaller than what was generally expected. By contrast, large right-lateral displacement takes place in northwestern Iran (up to 8 ± mm yr−1). The Central Iranian Block is characterized by coherent plate motion (internal deformation <2 mm yr−1). Sites east of 61°E show very low displacements relative to Eurasia. The kinematic contrast between eastern and western Iran is accommodated by strike-slip motions along the Lut Block. To the south, the transition zone between Zagros and Makran is under transpression with right-lateral displacements of 11 ± 2 mm yr−1.
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| 9. |
- Walpersdorf, A, et al.
(författare)
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Difference in the GPS deformation pattern of North and Central Zagros (Iran)
- 2006
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Ingår i: Geophysical Journal International. - 0956-540X .- 1365-246X. ; 167:3, s. 1077-1088
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Tidskriftsartikel (refereegranskat)abstract
- Measurements on either side of the Kazerun fault system in the Zagros Mountain Belt, Iran, show that the accommodation of the convergence of the Arabian and Eurasian Plates differs across the region. In northwest Zagros, the deformation is partitioned as 3–6 mm yr−1 of shortening perpendicular to the axis of the mountain belt, and 4–6 mm yr−1 of dextral strike-slip motion on northwest–southeast trending faults. No individual strike-slip fault seems to slip at a rate higher than ∼2 mm yr−1. In southeast Zagros, the deformation is pure shortening of 8 ± 2 mm yr−1 occurring perpendicular to the simple folded belt and restricted to the Persian Gulf shore. The fact that most of the deformation is located in front of the simple folded belt, close to the Persian Gulf, while seismicity is more widely spread across the mountain belt, confirms the decoupling of the surface sedimentary layers from the seismogenic basement. A comparison with the folding and topography corroborates a southwestward propagation of the surface deformation. The difference in deformation between the two regions suggests that right-lateral shear cumulates on the north–south trending Kazerun strike-slip fault system to 6 ± 2 mm yr−1.
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