| 1. |
- Kim, Joon Tae, et al.
(författare)
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Dual antiplatelet Use for extended period taRgeted to AcuTe ischemic stroke with presumed atherosclerotic OrigiN (DURATION) trial : Rationale and design
- 2023
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Ingår i: International Journal of Stroke. - : SAGE Publications. - 1747-4930 .- 1747-4949. ; 18:8, s. 1015-1020
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Tidskriftsartikel (refereegranskat)abstract
- Rationale: The optimal duration of dual antiplatelet therapy (DAPT) with clopidogrel-aspirin for the large artery atherosclerotic (LAA) stroke subtype has been debated. Aims: To determine whether the 1-year risk of recurrent vascular events could be reduced by a longer duration of DAPT in patients with the LAA stroke subtype. Methods and study design: A total of 4806 participants will be recruited to detect a statistically significant relative risk reduction of 22% with 80% power and a two-sided alpha error of 0.05, including a 10% loss to follow-up. This is a registry-based, multicenter, prospective, randomized, open-label, blinded end point study designed to evaluate the efficacy and safety of a 12-month duration of DAPT compared with a 3-month duration of DAPT in the LAA stroke subtype. Patients will be randomized (1:1) to either DAPT for 12 months or DAPT for 3 months, followed by monotherapy (either aspirin or clopidogrel) for the remaining 9 months. Study outcomes: The primary efficacy outcome of the study is a composite of stroke (ischemic or hemorrhagic), myocardial infarction, and all-cause mortality for 1 year after the index stroke. The secondary efficacy outcomes are (1) stroke, (2) ischemic stroke or transient ischemic attack, (3) hemorrhagic stroke, and (4) all-cause mortality. The primary safety outcome is major bleeding. Discussion: This study will help stroke physicians determine the appropriate duration of dual therapy with clopidogrel-aspirin for patients with the LAA stroke subtype. Trial registration: URL: https://cris.nih.go.kr/cris. CRIS Registration Number: KCT0004407.
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| 2. |
- Kim, Young-Seok, et al.
(författare)
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Built-in RNA-mediated chaperone (chaperna) for antigen folding tailored to immunized hosts
- 2020
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Ingår i: Biotechnology and Bioengineering. - : Wiley. - 0006-3592 .- 1097-0290. ; 117:7, s. 1990-2007
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Tidskriftsartikel (refereegranskat)abstract
- High-quality antibody (Ab) production depends on the availability of immunologically relevant antigens. We present a potentially universal platform for generating soluble antigens from bacterial hosts, tailored to immunized animals for Ab production. A novel RNA-dependent chaperone, in which the target antigen is genetically fused with an RNA-interacting domain (RID) docking tag derived from the immunized host, promotes the solubility and robust folding of the target antigen. We selected the N-terminal tRNA-binding domain of lysyl-tRNA synthetase (LysRS) as the RID for fusion with viral proteins and demonstrated the expression of the RID fusion proteins in their soluble and native conformations; immunization predominantly elicited Ab responses to the target antigen, whereas the self RID tag remained nonimmunogenic. Differential immunogenicity of the fusion proteins greatly enriched and simplified the screening of hybridoma clones of monoclonal antibodies (mAbs), enabling specific and sensitive serodiagnosis of MERS-CoV infection. Moreover, mAbs against the consensus influenza hemagglutinin stalk domain enabled a novel assay for trivalent seasonal influenza vaccines. The Fc-mediated effector function was demonstrated, which could be harnessed for the design of next-generation universal influenza vaccines. The nonimmunogenic built-in antigen folding module tailored to a repertoire of immunized animal hosts will drive immunochemical diagnostics, therapeutics, and designer vaccines.
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| 3. |
- Parveen, Nazish, et al.
(författare)
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Facile Synthesis of SnS2 Nanostructures with Different Morphologies for High-Performance Supercapacitor Applications
- 2018
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Ingår i: ACS Omega. - : AMER CHEMICAL SOC. - 2470-1343. ; 3:2, s. 1581-1588
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Tidskriftsartikel (refereegranskat)abstract
- SnS2 is an emerging candidate for an electrode material because of the considerable interlayer spaces in its crystal structures and the large surface area. SnS2 as a photocatalyst and in lithium ion batteries has been reported. On the other hand, there are only a few reports of their supercapacitor applications. In this study, sheetlike SnS2 (SL-SnS2), flowerlike SnS2 (FL-SnS2), and ellipsoid-like SnS2 (EL-SnS2) were fabricated via a facile solvothermal route using different types of solvents. The results suggested that the FL-SnS2 exhibited better capacitive performance than the SL-SnS2 and EL-SnS2, which means that the morphology has a significant effect on the electrochemical reaction. The FL-SnS2 displayed higher supercapacitor performance with a high capacity of approximately similar to 431.82 F/g at a current density of 1 A/g. The remarkable electrochemical performance of the FL-SnS2 could be attributed to the large specific surface area and better average pore size. These results suggest that a suitable solvent is appropriate for the large-scale construction of SnS2 with different morphologies and also has huge potential in the practical applications of high-performance supercapacitors.
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| 4. |
- Parveen, Nazish, et al.
(författare)
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Feasibility of using hollow double walled Mn2O3 nanocubes for hybrid Na-air battery
- 2019
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Ingår i: Chemical Engineering Journal. - : ELSEVIER SCIENCE SA. - 1385-8947 .- 1873-3212. ; 360, s. 415-422
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Tidskriftsartikel (refereegranskat)abstract
- Synthesis of the strongly anisotropic materials, such as highly porous hollow double walled cubes are considered excellent approach to maximize the diffusion of electrolytes. Herein, hollow doubled walled (HDW) Mn2O3 nanocubes (NCs) were synthesized by facile hydrothermal method followed by calcination method. The growth of nanocubes were studied by performing hydrothermal reaction at different times ranging from 3 to 9 h. Thereafter, the feasibility of prepared HDW NCs as air cathode in hybrid Na-air battery was systematically investigated. Among all, the sample prepared by 9 h hydrothermal treatment showed superior performance than 3 and 6 h samples. The fabricated hybrid Na-air cell using HDW Mn2O3 NCs displayed 330 mV overpotential gap and 90% electrical energy efficiency at 5 mA g(-1) current density, maximum of 0.2Wg(-1) power density and good cyclic stability up to 75 cycles which is attributed to the highly porous nature of material that allows efficient diffusion of electrolyte ions and oxygen from air. Thus, present investigation suggests that HDW Mn2O3 NCs can be a potential air cathode and can be utilized in other metal-air battery systems.
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