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- Campbell, PJ, et al.
(författare)
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Pan-cancer analysis of whole genomes
- 2020
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 1476-4687 .- 0028-0836. ; 578:7793, s. 82-
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Tidskriftsartikel (refereegranskat)abstract
- Cancer is driven by genetic change, and the advent of massively parallel sequencing has enabled systematic documentation of this variation at the whole-genome scale1–3. Here we report the integrative analysis of 2,658 whole-cancer genomes and their matching normal tissues across 38 tumour types from the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA). We describe the generation of the PCAWG resource, facilitated by international data sharing using compute clouds. On average, cancer genomes contained 4–5 driver mutations when combining coding and non-coding genomic elements; however, in around 5% of cases no drivers were identified, suggesting that cancer driver discovery is not yet complete. Chromothripsis, in which many clustered structural variants arise in a single catastrophic event, is frequently an early event in tumour evolution; in acral melanoma, for example, these events precede most somatic point mutations and affect several cancer-associated genes simultaneously. Cancers with abnormal telomere maintenance often originate from tissues with low replicative activity and show several mechanisms of preventing telomere attrition to critical levels. Common and rare germline variants affect patterns of somatic mutation, including point mutations, structural variants and somatic retrotransposition. A collection of papers from the PCAWG Consortium describes non-coding mutations that drive cancer beyond those in the TERT promoter4; identifies new signatures of mutational processes that cause base substitutions, small insertions and deletions and structural variation5,6; analyses timings and patterns of tumour evolution7; describes the diverse transcriptional consequences of somatic mutation on splicing, expression levels, fusion genes and promoter activity8,9; and evaluates a range of more-specialized features of cancer genomes8,10–18.
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- 2019
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Tidskriftsartikel (refereegranskat)
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| 7. |
- Clark, Gary F., et al.
(författare)
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Tumor Biomarker Glycoproteins in the Seminal Plasma of Healthy Human Males Are Endogenous Ligands for DC-SIGN
- 2012
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Ingår i: Molecular & Cellular Proteomics. - 1535-9476 .- 1535-9484. ; 11:1
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Tidskriftsartikel (refereegranskat)abstract
- DC-SIGN is an immune C-type lectin that is expressed on both immature and mature dendritic cells associated with peripheral and lymphoid tissues in humans. It is a pattern recognition receptor that binds to several pathogens including HIV-1, Ebola virus, Mycobacterium tuberculosis, Candida albicans, Helicobacter pylori, and Schistosoma mansoni. Evidence is now mounting that DC-SIGN also recognizes endogenous glycoproteins, and that such interactions play a major role in maintaining immune homeostasis in humans and mice. Autoantigens (neoantigens) are produced for the first time in the human testes and other organs of the male urogenital tract under androgenic stimulus during puberty. Such antigens trigger autoimmune orchitis if the immune response is not tightly regulated within this system. Endogenous ligands for DC-SIGN could play a role in modulating such responses. Human seminal plasma glycoproteins express a high level of terminal Lewis(x) and Lewis(y) carbohydrate antigens. These epitopes react specifically with the lectin domains of DC-SIGN. However, because the expression of these sequences is necessary but not sufficient for interaction with DC-SIGN, this study was undertaken to determine if any seminal plasma glycoproteins are also endogenous ligands for DC-SIGN. Glycoproteins bearing terminal Lewis(x) and Lewis(y) sequences were initially isolated by lectin affinity chromatography. Protein sequencing established that three tumor biomarker glycoproteins (clusterin, galectin-3 binding glycoprotein, prostatic acid phosphatase) and protein C inhibitor were purified by using this affinity method. The binding of DC-SIGN to these seminal plasma glycoproteins was demonstrated in both Western blot and immunoprecipitation studies. These findings have confirmed that human seminal plasma contains endogenous glycoprotein ligands for DC-SIGN that could play a role in maintaining immune homeostasis both in the male urogenital tract and the vagina after coitus.
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| 8. |
- Gomes, Ashen, et al.
(författare)
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Impulse flashover characteristics of oil palm trunk (OPT) veneer plywood
- 2018
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Ingår i: 34th International Conference on Lightning Protection, ICLP 2018. - : Institute of Electrical and Electronics Engineers Inc.. - 9781538666357
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Konferensbidrag (refereegranskat)abstract
- Oil palm is one of the largest crop industries in South East Asia, thus, it is of importance to use all parts of the Oil palm trees. Recently Oil Palm Trunks (OPT) have been used to make veneer, which can be processed to produce plywood. Even though OPT plywood doesn't have the same mechanical properties as timber, with proper treatment and adhesives during the processing of veneer to plywood, it can be made to compete with hardwood. OPT plywood has been used in various applications from wooden appliances to housing and roofing structures. These structures are at risk of surface flashovers through lightning and electrical breakdowns. However, no study has been conducted on the effects or characteristics of OPT plywood. In this paper, the effects of impulse surface flashover under different conditions on three-layered OPT plywood has been analyzed. Experiments were conducted to identify the characteristics of OPT under clean and dry, clean and wet, and contaminated surface conditions for both parallel and perpendicular fiber orientations. The 50% breakdown voltage was determined by the up and down method. Results identified the importance of the fibre orientation and the decrease in breakdown voltage under contaminants.
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| 9. |
- Lin, X., et al.
(författare)
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Message from the BDCloud 2018 Chairs
- 2019
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Ingår i: Proceedings - 16th IEEE International Symposium on Parallel and Distributed Processing with Applications, 17th IEEE International Conference on Ubiquitous Computing and Communications, 8th IEEE International Conference on Big Data and Cloud Computing, 11th IEEE International Conference on Social Computing and Networking and 8th IEEE International Conference on Sustainable Computing and Communications, ISPA/IUCC/BDCloud/SocialCom/SustainCom 2018. - : Institute of Electrical and Electronics Engineers Inc.. ; , s. XXIX-XXX
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Konferensbidrag (refereegranskat)
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