| 1. |
- Sliz, E., et al.
(författare)
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Evidence of a causal effect of genetic tendency to gain muscle mass on uterine leiomyomata
- 2023
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Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 14:1
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Tidskriftsartikel (refereegranskat)abstract
- Uterine leiomyomata (UL) are the most common tumours of the female genital tract and the primary cause of surgical removal of the uterus. Genetic factors contribute to UL susceptibility. To add understanding to the heritable genetic risk factors, we conduct a genome-wide association study (GWAS) of UL in up to 426,558 European women from FinnGen and a previous UL meta-GWAS. In addition to the 50 known UL loci, we identify 22 loci that have not been associated with UL in prior studies. UL-associated loci harbour genes enriched for development, growth, and cellular senescence. Of particular interest are the smooth muscle cell differentiation and proliferation-regulating genes functioning on the myocardin-cyclin dependent kinase inhibitor 1A pathway. Our results further suggest that genetic predisposition to increased fat-free mass may be causally related to higher UL risk, underscoring the involvement of altered muscle tissue biology in UL pathophysiology. Overall, our findings add to the understanding of the genetic pathways underlying UL, which may aid in developing novel therapeutics.
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| 2. |
- Riley, M A, et al.
(författare)
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Beyond band termination in Er-157 and the search for wobbling excitations in strongly deformed Hf-174
- 2005
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Ingår i: Journal of Physics G: Nuclear and Particle Physics. - : IOP Publishing. - 0954-3899 .- 1361-6471. ; 31:10, s. 1735-1740
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Tidskriftsartikel (refereegranskat)abstract
- High-spin terminating bands in heavy nuclei were first identified in nuclei around Er-158(90). While examples of special terminating states have been identified in a number of erbium isotopes, almost nothing is known about the states lying beyond band termination. In the present work the high-spin structure of Er-157 has been studied using the Gammasphere spectrometer. The subject of triaxial superdeformation and 'wobbling' modes in Lu nuclei has rightly attracted a great deal of attention. Very recently, four strongly or superdeformed (SD) sequences have been observed in Hf-174 and ultimate cranker calculations predict, such structures may have significant triaxial deformation. We have performed two experiments in an attempt to verify the possible triaxial nature of these bands. A lifetime measurement was performed to confirm the large (and similar) deformation of the bands. In addition, a high-statistics, thin-target experiment was run to search for linking transitions between the SD bands and possible wobbling modes.
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| 3. |
- Riley, M. A., et al.
(författare)
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Observation of states beyond band termination in Er-156,Er-157,Er-158 and strongly deformed structures in Hf-173,Hf-174,Hf-175
- 2006
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Ingår i: Physica Scripta. - 0031-8949. ; T125, s. 123-126
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Tidskriftsartikel (refereegranskat)abstract
- High-spin terminating bands in heavy nuclei were first identified in nuclei around Er-158(90). While examples of terminating states have been identified in a number of erbium isotopes, almost nothing is known about the states lying beyond band termination. In the present work, the high-spin structure of Er-156,Er-157,Er-158 has been studied using the Gammasphere spectrometer. The subject of triaxial superdeformation and 'wobbling' modes in Lu nuclei has rightly attracted a great deal of attention. Very recently four strongly or superdeformed (SD) sequences have been observed in Hf-174, and cranking calculations using the Ultimate Cranker code predict that such structures may have significant triaxial deformation. We have performed two experiments in an attempt to verify the possible triaxial nature of these bands. A lifetime measurement was performed to confirm the large (and similar) deformation of the bands. In addition, a high-statistics, thin-target experiment took place to search for linking transitions between the SD bands, possible wobbling modes, and new SD band structures.
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| 4. |
- Simpson, J., et al.
(författare)
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Evolution of structure and shapes in Er 158 to ultrahigh spin
- 2023
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Ingår i: Physical Review C. - 2469-9985. ; 107:5
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Tidskriftsartikel (refereegranskat)abstract
- The level structure of Er158 has been studied using the Gammasphere spectrometer via the Cd114(Ca48,4n) reaction at 215 MeV with both thin (self-supporting) and thick (backed) targets. The level scheme has been considerably extended with more than 200 new transitions and six new rotational structures, including two strongly coupled high-K bands. Configuration assignments for the new structures are based on their observed alignments, B(M1)/B(E2) ratios of reduced transition probabilities, excitation energies, and comparisons with neighboring nuclei and theoretical calculations. With increasing angular momentum, this nucleus exhibits Coriolis-induced alignments of both neutrons and protons before it then undergoes a rotation-induced transition from near-prolate collective rotation to a noncollective oblate configuration. This transition occurs via the mechanism of band termination around spin 45ħ in three rotational structures. Two distinct lifetime branches, consistent with the crossing of a collective "fast"rotational structure by an energetically favored "slow"terminating sequence, are confirmed for the positive-parity states, and similar behavior is established in the negative-parity states. Weak-intensity, high-energy transitions are observed to feed into the terminating states. At the highest spins, three collective bands with high dynamic moments of inertia and large quadrupole moments were identified. These bands are interpreted as triaxial strongly deformed structures and mark a return to collectivity at ultrahigh spin.
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| 5. |
- Paul, E. S., et al.
(författare)
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The highest spin discrete levels in Ce-131,Ce-132
- 2006
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Ingår i: Physica Scripta. - 0031-8949. ; T125, s. 115-118
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Tidskriftsartikel (refereegranskat)abstract
- The three superdeformed (SD) bands in Ce-132 and the two SD bands in Ce-131 have been extended to higher spin following experiments with the EUROBALL IV spectrometer. The two SD bands in 131Ce have been linked together. However, despite the relatively high population intensity of the bands ( up to 5% of the respective channel), it has not been possible to unambiguously link any of the five SD bands into the low-spin, normally deformed structures of Ce-131,Ce-132.
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| 6. |
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| 7. |
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| 8. |
- Paul, E. S., et al.
(författare)
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Loss of collectivity in the transitional Er-156 nucleus at high spin
- 2009
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Ingår i: Physical Review C (Nuclear Physics). - 0556-2813. ; 79:4
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Tidskriftsartikel (refereegranskat)abstract
- The Cd-114(Ca-48, 6n gamma) reaction at 215 MeV has been investigated using the Gammasphere spectrometer to study the high-spin structure of the nucleus Er-156(68)88. Many new transitions have been established along with 68 definitive spin-parity level assignments from a high-fold angular-distribution analysis. In addition, absolute B(M 1) and B(E 1) strengths have been inferred from measured gamma-ray branching ratios. Strong B(E 1) strength (10(-3) W.u.) is discussed in terms of possible octupole collectivity at low spin. At high spin, this nucleus undergoes a Coriolis-induced shape transition from a prolate state of collective rotation to a noncollective, triaxial-oblate configuration. The yrast positive-parity structure ultimately terminates in an energetically favored oblate state at I-pi = 42(+). Several weak high-energy gamma-ray transitions have been discovered that feed this favored state. State-of-the-art cranked Nilsson-Strutinsky calculations are used to interpret the high-spin behavior of Er-156 and comparisons are made with other N = 88 isotones.
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| 9. |
- Paul, E. S., et al.
(författare)
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Return of collective rotation in Er-157 and Er-158 at ultrahigh spin
- 2007
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Ingår i: Physical Review Letters. - 1079-7114. ; 98:1, s. 1-012501
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Tidskriftsartikel (refereegranskat)abstract
- A new frontier of discrete-line gamma-ray spectroscopy at ultrahigh spin has been opened in the rare-earth nuclei Er-157,Er-158. Four rotational structures, displaying high moments of inertia, have been identified, which extend up to spin similar to 65h and bypass the band-terminating states in these nuclei which occur at similar to 45h. Cranked Nilsson-Strutinsky calculations suggest that these structures arise from well-deformed triaxial configurations that lie in a valley of favored shell energy which also includes the triaxial strongly deformed bands in Lu161-167.
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| 10. |
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