| 1. |
- Denver, Sigrid, et al.
(författare)
-
Samspil mellem økologisk forbrug og sundhed
- 2018
-
Ingår i: Øget efterspørgsel efter danske økologiske fødevarer: : Tre studier af motiver og ønsker hos forbrugerne med fokus på sundhed, lokale fødevarer og øget eksport. - Tre studier af motiver og ønsker hos forbrugerne med fokus på sundhed, lokale fødevarer og øget eksport.. - : Frederiksberg: Institut for Fødevare- og Ressourceøkonomi, Københavns Universitet. - 9788792591883 ; , s. 11-33
-
Bokkapitel (övrigt vetenskapligt/konstnärligt)
|
|
| 2. |
- Blauenfeldt, Rolf Ankerlund, et al.
(författare)
-
Remote Ischemic Conditioning for Acute Stroke : The RESIST Randomized Clinical Trial
- 2023
-
Ingår i: JAMA. - 0098-7484. ; 330:13, s. 1236-1246
-
Tidskriftsartikel (refereegranskat)abstract
- Importance: Despite some promising preclinical and clinical data, it remains uncertain whether remote ischemic conditioning (RIC) with transient cycles of limb ischemia and reperfusion is an effective treatment for acute stroke. Objective: To evaluate the effect of RIC when initiated in the prehospital setting and continued in the hospital on functional outcome in patients with acute stroke. Design, Setting, and Participants: This was a randomized clinical trial conducted at 4 stroke centers in Denmark that included 1500 patients with prehospital stroke symptoms for less than 4 hours (enrolled March 16, 2018, to November 11, 2022; final follow-up, February 3, 2023). Intervention: The intervention was delivered using an inflatable cuff on 1 upper extremity (RIC cuff pressure, ≤200 mm Hg [n = 749] and sham cuff pressure, 20 mm Hg [n = 751]). Each treatment application consisted of 5 cycles of 5 minutes of cuff inflation followed by 5 minutes of cuff deflation. Treatment was started in the ambulance and repeated at least once in the hospital and then twice daily for 7 days among a subset of participants. Main Outcomes and Measures: The primary end point was improvement in functional outcome measured as a shift across the modified Rankin Scale (mRS) score (range, 0 [no symptoms] to 6 [death]) at 90 days in the target population with a final diagnosis of ischemic or hemorrhagic stroke. Results: Among 1500 patients who were randomized (median age, 71 years; 591 women [41%]), 1433 (96%) completed the trial. Of these, 149 patients (10%) were diagnosed with transient ischemic attack and 382 (27%) with a stroke mimic. In the remaining 902 patients with a target diagnosis of stroke (737 [82%] with ischemic stroke and 165 [18%] with intracerebral hemorrhage), 436 underwent RIC and 466 sham treatment. The median mRS score at 90 days was 2 (IQR, 1-3) in the RIC group and 1 (IQR, 1-3) in the sham group. RIC treatment was not significantly associated with improved functional outcome at 90 days (odds ratio [OR], 0.95; 95% CI, 0.75 to 1.20, P =.67; absolute difference in median mRS score, -1; -1.7 to -0.25). In all randomized patients, there were no significant differences in the number of serious adverse events: 169 patients (23.7%) in the RIC group with 1 or more serious adverse events vs 175 patients (24.3%) in the sham group (OR, 0.97; 95% CI, 0.85 to 1.11; P =.68). Upper extremity pain during treatment and/or skin petechia occurred in 54 (7.2%) in the RIC group and 11 (1.5%) in the sham group. Conclusions and Relevance: RIC initiated in the prehospital setting and continued in the hospital did not significantly improve functional outcome at 90 days in patients with acute stroke. Trial Registration: ClinicalTrials.gov Identifier: NCT03481777.
|
|
| 3. |
- Bridel, Claire, et al.
(författare)
-
Diagnostic Value of Cerebrospinal Fluid Neurofilament Light Protein in Neurology : A Systematic Review and Meta-analysis
- 2019
-
Ingår i: JAMA Neurology. - : American Medical Association (AMA). - 2168-6149 .- 2168-6157. ; 76:9, s. 1035-1048
-
Forskningsöversikt (refereegranskat)abstract
- Importance Neurofilament light protein (NfL) is elevated in cerebrospinal fluid (CSF) of a number of neurological conditions compared with healthy controls (HC) and is a candidate biomarker for neuroaxonal damage. The influence of age and sex is largely unknown, and levels across neurological disorders have not been compared systematically to date.Objectives To assess the associations of age, sex, and diagnosis with NfL in CSF (cNfL) and to evaluate its potential in discriminating clinically similar conditions.Data Sources PubMed was searched for studies published between January 1, 2006, and January 1, 2016, reporting cNfL levels (using the search terms neurofilament light and cerebrospinal fluid) in neurological or psychiatric conditions and/or in HC.Study Selection Studies reporting NfL levels measured in lumbar CSF using a commercially available immunoassay, as well as age and sex.Data Extraction and Synthesis Individual-level data were requested from study authors. Generalized linear mixed-effects models were used to estimate the fixed effects of age, sex, and diagnosis on log-transformed NfL levels, with cohort of origin modeled as a random intercept.Main Outcome and Measure The cNfL levels adjusted for age and sex across diagnoses.Results Data were collected for 10 059 individuals (mean [SD] age, 59.7 [18.8] years; 54.1% female). Thirty-five diagnoses were identified, including inflammatory diseases of the central nervous system (n = 2795), dementias and predementia stages (n = 4284), parkinsonian disorders (n = 984), and HC (n = 1332). The cNfL was elevated compared with HC in a majority of neurological conditions studied. Highest levels were observed in cognitively impaired HIV-positive individuals (iHIV), amyotrophic lateral sclerosis, frontotemporal dementia (FTD), and Huntington disease. In 33.3% of diagnoses, including HC, multiple sclerosis, Alzheimer disease (AD), and Parkinson disease (PD), cNfL was higher in men than women. The cNfL increased with age in HC and a majority of neurological conditions, although the association was strongest in HC. The cNfL overlapped in most clinically similar diagnoses except for FTD and iHIV, which segregated from other dementias, and PD, which segregated from atypical parkinsonian syndromes.Conclusions and Relevance These data support the use of cNfL as a biomarker of neuroaxonal damage and indicate that age-specific and sex-specific (and in some cases disease-specific) reference values may be needed. The cNfL has potential to assist the differentiation of FTD from AD and PD from atypical parkinsonian syndromes.
|
|
| 4. |
- Denver, Sigrid, et al.
(författare)
-
Consumer preferences for low-salt foods - a Danish case study based on a comprehensive supermarket intervention.
- 2021
-
Ingår i: Public Health Nutrition. - 1368-9800 .- 1475-2727. ; 24:12, s. 3956-3965
-
Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE: The objective is to analyze Danish consumers' attitudes to buying food with reduced salt content.DESIGN: The study is based on a comprehensive store intervention that included 114 stores belonging to the same supermarket chain. Three different salt claims were tested for eight weeks on six test products within the categories bread, cornflakes and frozen pizzas. Scanner data were supplemented with 134 brief interviews with consumers in nine selected stores.SETTING: Stores spread across Denmark.PARTICIPANTS: Consumers who buy food in the stores.RESULTS: Statistical regression analyses of the scanner data indicated that none of the three claims significantly affected demand for any of the test products. The interviews confirmed that many consumers were more focused on other elements of the official dietary advice than reduced salt consumption, such as eating plenty of vegetables, choosing products with whole grains and reducing their intake of sugar and fat.CONCLUSIONS: Overall, both the scanner data and the interviews pointed in the same direction, toward the conclusion that salt content is often a secondary factor when Danish consumers make dietary choices.
|
|
| 5. |
|
|
| 6. |
- Denver, Sigrid, et al.
(författare)
-
Dietary priorities and consumers’ views of the healthiness of organic food : purity or flexibility?
- 2022
-
Ingår i: Organic Agriculture. - : Springer Science and Business Media LLC. - 1879-4238 .- 1879-4246. ; 12:2, s. 163-175
-
Tidskriftsartikel (refereegranskat)abstract
- Previous studies have shown that belief in the healthiness of organic food is a strong motive for buying organic. Typically, a positive relation between a nutritionally balanced diet (with respect to fruit, vegetables and meat) and organic consumption is also found. As market shares of organic food are much smaller than those of conventional food, consumers may face a trade-off between buying organic and choosing the nutritional composition they prefer. Using data from a survey of around 1300 Danish consumers, we found that almost all respondents believed that organic food contains fewer unwanted substances than non-organic food, and that around a third considered organic food to be nutritionally superior. Respondents with high organic consumption and who believe in the nutritious superiority of organic food products were more likely to belong to a small group of respondents who prioritized buying organic. However, the vast majority, particularly those with low levels of organic consumption, prioritized dietary flexibility over organic produce. Our findings suggest that to motivate those in this large consumer segment to increase their organic consumption, it will be necessary to offer a broader, more nutritionally differentiated, range of organic products.
|
|
| 7. |
|
|
| 8. |
- Denver, Sigrid, et al.
(författare)
-
Is an Increase in Organic Consumption Accompanied by A Healthier Diet? : A Comparison of Changes in Eating Habits among Danish Consumers
- 2019
-
Ingår i: Journal of Food Products Marketing. - : Informa UK Limited. - 1045-4446 .- 1540-4102. ; 25:5, s. 479-499
-
Tidskriftsartikel (refereegranskat)abstract
- Several studies have shown that consumers with a high organic consumption often have dietary habits that include more fruit and vegetables but less red meat. This paper takes a novel approach by investigating whether changes in consumption of organics and improvements in dietary habits also are related. The results show that many consumers seem to improve their diet while increasing the organic consumption. Further, the study suggests that some households already have a relatively healthy diet in terms of fruit, vegetables, and meat consumption, when they start buying organic food. When organic consumption reaches a certain level, further increases in organic consumption are more likely to take place at the same time as dietary habits are improved. References to health and climate considerations seem to be the most important motivations for reducing meat consumption, while higher availability of organics is the most important reason for increasing organic consumption.
|
|
| 9. |
- Denver, Sigrid, et al.
(författare)
-
Plant-based food – Purchasing intentions, barriers and drivers among different organic consumer groups in Denmark
- 2023
-
Ingår i: Journal of Cleaner Production. - 0959-6526 .- 1879-1786. ; 419
-
Tidskriftsartikel (refereegranskat)abstract
- How do we design policies that support a shift in eating habits towards a diet that includes more vegetable-basedproducts and less meat, and in particular red meat? To inform policy, more information is needed about consumers’perceptions of the plant-based protein alternatives that have become available on the market. Thepresent study of 1000 Danish consumers examined oat drink and plant-based mince as substitutes for cows’ milkand minced beef. While the popularity of these is increasing, in 2021 70% of Danish consumers had nonethelessnever tried using oat drink or plant-based mince. Respondents who stated that they often bought organic foodwere more likely to associate the plant-based products with benefits as well as being more likely to have triedusing the plant-based products. While plant-based products were associated mainly with public good characteristics,it was private good characteristics that explained consumption of the products. Therefore, improvingtaste – or changing people’s expectations about it – and reducing price are ways to reduce barriers to consumption.Initiatives to improve public understanding of the ways in which plant-based and animal-basedproducts differ are also important, as many respondents were somewhat unclear about which characteristicsthey associated with the two products.
|
|
| 10. |
- Harnett, Tove, et al.
(författare)
-
Vardag, rutiner och makt
- 2013
-
Ingår i: Caresam; Åldrande och utmaningar i Öresundsregionen. Att arbeta med ældre i Sverige och Danmark.
-
Bokkapitel (populärvet., debatt m.m.)
|
|
