| 1. |
- Ajalloueian, Fatemeh, et al.
(författare)
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Bladder biomechanics and the use of scaffolds for regenerative medicine in the urinary bladder
- 2018
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Ingår i: Nature reviews. Urology. - : Springer Science and Business Media LLC. - 1759-4812 .- 1759-4820. ; 15:3, s. 155-174
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Forskningsöversikt (refereegranskat)abstract
- The urinary bladder is a complex organ with the primary functions of storing urine under low and stable pressure and micturition. Many clinical conditions can cause poor bladder compliance, reduced capacity, and incontinence, requiring bladder augmentation or use of regenerative techniques and scaffolds. To replicate an organ that is under frequent mechanical loading and unloading, special attention towards fulfilling its biomechanical requirements is necessary. Several biological and synthetic scaffolds are available, with various characteristics that qualify them for use in bladder regeneration in vitro and in vivo, including in the treatment of clinical conditions. The biomechanical properties of the native bladder can be investigated using a range of mechanical tests for standardized assessments, as well as mathematical and computational bladder biomechanics. Despite a large body of research into tissue engineering of the bladder wall, some features of the native bladder and the scaffolds used to mimic it need further elucidation. Collection of comparable reference data from different animal models would be a helpful tool for researchers and will enable comparison of different scaffolds in order to optimize characteristics before entering preclinical and clinical trials.
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| 2. |
- Kikionis, Stefanos, et al.
(författare)
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Nanofibrous nonwovens based on dendritic-linear-dendritic poly(ethylene glycol) hybrids
- 2018
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Ingår i: Journal of Applied Polymer Science. - : John Wiley & Sons. - 0021-8995 .- 1097-4628. ; 135:10
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Tidskriftsartikel (refereegranskat)abstract
- Dendritic-linear-dendritic (DLD) hybrids are highly functional materials combining the properties of linear and dendritic polymers. Attempts to electrospin DLD polymers composed of hyperbranched dendritic blocks of 2,2-bis(hydroxymethyl) propionic acid on a linear poly(ethylene glycol) core proved unsuccessful. Nevertheless, when these DLD hybrids were blended with an array of different biodegradable polymers as entanglement enhancers, nanofibrous nonwovens were successfully prepared by electrospinning. The pseudogeneration degree of the DLDs, the nature of the co-electrospun polymer and the solvent systems used for the preparation of the electrospinning solutions exerted a significant effect on the diameter and morphology of the electrospun fibers. It is worth-noting that aqueous solutions of the DLD polymers and only 1% (w/v) poly(ethylene oxide) resulted in the production of smoother and thinner nanofibers. Such dendritic nanofibrous scaffolds can be promising materials for biomedical applications due to their bio-compatibility, biodegradability, multifunctionality, and advanced structural architecture.
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| 3. |
- Zhou, Tongchang, et al.
(författare)
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Molecularly imprinted polymer beads for nicotine recognition prepared by RAFT precipitation polymerization: a step forward towards multi-functionalities
- 2014
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Ingår i: RSC Advances. - : Royal Society of Chemistry (RSC). - 2046-2069. ; 4:57, s. 30292-30299
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Tidskriftsartikel (refereegranskat)abstract
- A nicotine imprinted polymer was synthesized by reversible addition-fragmentation chain transfer (RAFT) polymerization using methacrylic acid (MAA) as a functional monomer. The resulting molecularly imprinted polymers were monodispersed beads with an average diameter of 1.55 mu m. The molecular selectivity of the imprinted polymer beads was evaluated by studying the uptake of nicotine and its structural analogs by the polymer beads. Equilibrium binding results indicate that the amount of nicotine bound to the imprinted polymer beads is significantly higher than that bound to the non-imprinted polymer in both acetonitrile and in a mixture of acetonitrile and water. The RAFT reagent present on the surface of the polymer beads allowed straightforward grafting of hydrophilic polymer brushes on the particle surface. In addition to the demonstrated molecular selectivity and the straightforward surface modification of the imprinted polymer beads, we also show that the dithioester end groups on the surface of the polymer beads can be converted into new thiol groups without sacrificing the specific molecular recognition. Through the new terminal thiol groups, a fluorescent dye was conveniently conjugated to the imprinted polymer beads via Michael addition reaction. The living characteristic of RAFT and the versatile thiol groups that can be derived from the RAFT reagent provide many new possibilities for realizing multi-functionalities for molecularly imprinted polymers.
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| 4. |
- Yoshimatsu, Keiichi, et al.
(författare)
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Influence of template/functional monomer/cross-linking monomer ratio on particle size and binding properties of molecularly imprinted nanoparticles
- 2012
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Ingår i: Journal of Applied Polymer Science. - : Wiley. - 1097-4628 .- 0021-8995. ; 124:2, s. 1249-1255
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Tidskriftsartikel (refereegranskat)abstract
- A series of molecularly imprinted polymer nanoparticles have been synthesized employing various template/functional monomer/crosslinking monomer ratio and characterized in detail to elucidate the correlation between the synthetic conditions used and the properties (e.g., particle size and template binding properties) of the obtained nanoparticles. In brief, the presence of propranolol (template) in the polymerization mixture turned out to be a critical factor on determination of the size as well as the binding properties of the imprinted nanoparticles. The functional monomer/crosslinking monomer ratio significantly affects the binding capability of the imprinted nanoparticles, but its influence on the size of the nanoparticles was found to be rather limited. The results obtained provide valuable clues for designing molecularly imprinted nanoparticle preparation in future studies, where fine tuning of particle size and binding properties are required to fit practical applications. (C) 2011 Wiley Periodicals, Inc. J Appl Polym Sci, 2012
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| 5. |
- Chronakis, Ioannis, et al.
(författare)
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MASMICRO micro-/nano-materials processing, analysis, inspection and materials knowledge management
- 2010
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Ingår i: The International Journal of Advanced Manufacturing Technology. - : Springer Science and Business Media LLC. - 0268-3768 .- 1433-3015. ; 47, s. 963-971
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Tidskriftsartikel (refereegranskat)abstract
- The main goals of the 'Material Innovation and Testing' within MASMICRO are the identification of the miniature/micro-materials which are formable, development of new materials for forming and machining, development of an integrated material-testing system and study of material properties for design/analysis applications. Examples of collaborative work and results are presented regarding the processing of functional electrospun polymer micro-/nano-fibre structures and the characterization of their interface properties with tribological testing. By means of optical coherence tomography, a non-destructive inspection approach for these micro-/nano-structured webs was developed and it is also documented in the paper. Further, an application example of artificial neural networks (ANNs) is given, concerning the modelling of nano-fibres material behaviour under tensile testing. It is shown how artificial intelligence approaches (knowledge-based systems-KBS and ANNs) can support, significantly, the representation and processing of materials' knowledge of both, symbolic type, in the case of KBS, and algorithmic type, in the case of ANNs, for the cases dealt within the MASMICRO. © Springer-Verlag London Limited 2009.
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| 6. |
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| 7. |
- Bolin, Maria, et al.
(författare)
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Nano-fiber scaffold electrodes based on PEDOT for cell stimulation
- 2009
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Ingår i: SENSORS AND ACTUATORS B-CHEMICAL. - : Elsevier BV. - 0925-4005 .- 1873-3077. ; 142:2, s. 451-456
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Tidskriftsartikel (refereegranskat)abstract
- Electronically conductive and electrochemically active 3D-scaffolds based on electrospun poly(ethylene terephthalate) (PET) nano-fibers are reported. Vapour phase polymerization was employed to achieve an uniform and conformal coating of poly(3,4-ethylenedioxythiophene) doped with tosylate (PEDOT:tosylate) on the nano-fibers. The PEDOT coatings had a large impact on the wettability, turning the hydrophobic PET fibers super-hydrophilic. SH-SY5Y neuroblastoma cells were grown on the PEDOT coated fibers. The SH-SY5Y cells adhered well and showed healthy morphology. These electrically active scaffolds were used to induce Ca2+ signalling in SH-SY5Y neuroblastoma cells. PEDOT:tosylate coated nano-fibers represent a class of 3D host environments that combines excellent adhesion and proliferation for neuronal cells with the possibility to regulate their signalling.
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| 8. |
- Verma, Suresh Chand, et al.
(författare)
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Metal - Polymer composite nanofibres by electrospinning
- 2009
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Ingår i: Journal of Nanostructured Polymers and Nanocomposites. - 1790-4439. ; 5:2, s. 25-29
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Tidskriftsartikel (refereegranskat)abstract
- Electrospinning is a versatile technique of producing continuous fibres and structures with diameters in sub-micron range from rich variety of polymers and their composites. Traditionally polymers in the form of solution or melt are used for electrospinning. For the first time, we utilized the co-axial electrospinning process to produce core-shell structured metal-polymer nanofibres using metal (core) and polymer (shell). A range of different polymer solutions (polyethylene oxide, poly(vinyl pyrrolidone) and polyurethane) and eutectic metal alloys of two different melting points, namely MCP47 and MCP70, were investigated. The morphological structure of the resultant composite nanofibres has been studied by means of scanning electron microscopy (SEM) and transmission electron microscopy (TEM).
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| 9. |
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| 10. |
- Yoshimatsu, Keiichi, et al.
(författare)
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Selective molecular adsorption using electrospun nanofiber affinity membranes.
- 2008
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Ingår i: Biosensors & Bioelectronics. - : Elsevier BV. - 1873-4235 .- 0956-5663. ; 23:7, s. 1208-1215
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Tidskriftsartikel (refereegranskat)abstract
- Molecularly imprinted nanoparticles were encapsulated into polymer nanofibers with a simple electrospinning method. The composite nanofibers form non-woven mats that can be used as affinity membrane to greatly simplify solid phase extraction of drug residues in analytical samples. Upward 100% of propranolol-imprinted nanoparticles can be easily encapsulated into poly(ethylene terephthalate) nanofibers, ensuring the composite materials to have a high specific binding capacity. As confirmed by radioligand binding analysis, the specific binding sites in the composite materials remain easily accessible and are chiral-selective. Using the new composite nanofiber mats as solid phase extraction materials, trace amount of propranolol (1ngmL(-1)) in tap water can be easily detected after a simple sample preparation. As validated in this study, there is no problem of template leakage from the composite nanofibers. Without the solid phase extraction, the existence of propranolol residues in water cannot be confirmed with even tandem HPLC-MS/MS analysis.
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