| 1. |
- Bovo, Roberto, et al.
(författare)
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Hearing impairment in the Sturge-Weber syndrome
- 2009
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Ingår i: European Journal of Clinical Investigation. - Oxford, UK : Wiley-Blackwell Publishing Inc.. - 0014-2972 .- 1365-2362. ; 39:9, s. 837-838
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Tidskriftsartikel (refereegranskat)
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| 2. |
- Ciorba, A., et al.
(författare)
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Postoperative complications in cochlear implants : a retrospective analysis of 438 consecutive cases
- 2012
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Ingår i: European Archives of Oto-Rhino-Laryngology. - Berlin, Germany : Springer. - 0937-4477 .- 1434-4726. ; 269:6, s. 1599-1603
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Tidskriftsartikel (refereegranskat)abstract
- Our objective is to determine the complication rate in a population of infants, children, adolescents and adults, from a University Hospital Cochlear Implant program and to discuss their causes and treatments. The methods include a retrospective study of 438 consecutive patients in a tertiary referral centre, the Audiology Department of the University Hospital of Ferrara. All patients receiving cochlear implants, between 1 January 2003 and 31 December 2009, have been included. All complications and treatments were systematically reviewed with an average duration of follow-up of 46 months (range 10-84 months). The results reveal that the overall rate of complications in our group was 9.1% (40 of 438), and most of them were minor. Wound swelling and infections represent the most common complication occurred. There were no cases of transient or permanent facial palsy following surgery, and also we did not register any case of postsurgical meningitis. Thirteen patients (3.0%) underwent explantation followed by reimplantation. In conclusion, we find that Cochlear implantation is a safe low-morbility technique with a relatively low complication rate in the presented population.
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| 3. |
- Gonzalez-Perez, V., et al.
(författare)
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Goblet cell LRRC26 regulates BK channel activation and protects against colitis in mice
- 2021
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Ingår i: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 0027-8424. ; 118:3
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Tidskriftsartikel (refereegranskat)abstract
- Y Goblet cells (GCs) are specialized cells of the intestinal epithelium contributing critically to mucosal homeostasis. One of the functions of GCs is to produce and secrete MUC2, the mucin that forms the scaffold of the intestinal mucus layer coating the epithelium and separates the luminal pathogens and commensal microbiota from the host tissues. Although a variety of ion channels and transporters are thought to impact on MUC2 secretion, the specific cellular mechanisms that regulate GC function remain incompletely understood. Previously, we demonstrated that leucine-rich repeat-containing protein 26 (LRRC26), a known regulatory subunit of the Ca2+-and voltage-activated K+ channel (BK channel), localizes specifically to secretory cells within the intestinal tract. Here, utilizing a mouse model in which MUC2 is fluorescently tagged, thereby allowing visualization of single GCs in intact colonic crypts, we show that murine colonic GCs have functional LRRC26-associated BK channels. In the absence of LRRC26, BK channels are present in GCs, but are not activated at physiological conditions. In contrast, all tested MUC2(-) cells completely lacked BK channels. Moreover, LRRC26-associated BK channels underlie the BK channel contribution to the resting transepithelial current across mouse distal colonic mucosa. Genetic ablation of either LRRC26 or BK pore-forming alpha-subunit in mice results in a dramatically enhanced susceptibility to colitis induced by dextran sodium sulfate. These results demonstrate that normal potassium flux through LRRC26-associated BK channels in GCs has protective effects against colitis in mice.
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| 4. |
- Ciorba, Andrea, et al.
(författare)
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Sudden bilateral sensorineural hearing loss as an unusual consequence of accidental ingestion of potassium hydroxide
- 2010
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Ingår i: Medical principles and practice. - Basel : S. Karger. - 1011-7571 .- 1423-0151. ; 19:5, s. 406-408
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Tidskriftsartikel (refereegranskat)abstract
- Objective: To discuss the possible etiopathogenetic mechanism of inner ear damage induced by the ingestion of potassium hydroxide (KOH).Clinical presentation and intervention: We report the case of a 37-year-old patient with sudden bilateral sensorineural hearing loss after accidental ingestion of a KOH solution. The first ear, nose and throat examination disclosed only mild edema of the upper airways. He was treated in the intensive care unit and prescribed high-dose steroids, proton pump inhibitors and sucralfate for 2 weeks. Unfortunately, there was no recovery of the hearing loss, and no audiogram changes were noticed after 12 months of follow-up.Conclusion: After exploring the possible etiopathogenetic mechanism involved, the authors believe that in this case, a transient severe hemodynamic imbalance can actually be considered to be the most reliable explanation for the inner ear damage and subsequent onset of permanent bilateral sensorineural hearing loss.
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