| 1. |
|
|
| 2. |
|
|
| 3. |
|
|
| 4. |
- Carlsson, G, et al.
(författare)
-
Periodontal disease in patients from the original Kostmann family with severe congenital neutropenia
- 2006
-
Ingår i: Journal of Periodontology. - : Wiley. - 0022-3492 .- 1943-3670. ; 77:4, s. 744-751
-
Tidskriftsartikel (refereegranskat)abstract
- Patients with Kostmann syndrome (severe congenital neutropenia [SCN]) typically normalize their absolute neutrophil count (ANC) upon granulocyte colony-stimulating factor (G-CSF) therapy. However, although they no longer experience life-threatening bacterial infections, they frequently still have recurrent gingivitis and even severe periodontitis, often starting in early childhood. METHODS: We studied the periodontal disease in the four surviving patients belonging to the family originally described by Kostmann. Their odontological records, x-rays, color photos, bacterial cultures, serum antibodies to oral bacteria, and histopathological examinations were reviewed. The data were also correlated to previous investigations on their antibacterial peptides and molecular biology. RESULTS: Three patients had periodontal disease, despite normal ANC and professional dental care, and had neutrophils deficient in antibacterial peptides. One of these patients also had a heterozygous mutation in the neutrophil elastase gene, had severe periodontal disease and overgrowth of the periodontal pathogen Actinobacillus actinomycetemcomitans in the dental flora, and 15 permanent teeth had been extracted by the age of 27. One bone marrow-transplanted patient had no periodontal disease. CONCLUSIONS: Normalized ANC levels are not sufficient to maintain normal oral health in SCN patients, and because neutrophils are important for first-line defense and innate immunity, the deficiency of the antibacterial peptide LL-37 probably explains their chronic periodontal disease. Professional dental care is still important for SCN patients, despite treatment with G-CSF and normal ANC levels. Whether antibacterial peptides play a role in the pathogenesis of periodontitis in other patients remains to be elucidated.
|
|
| 5. |
- Carlsson, Jan, et al.
(författare)
-
Catalase inhibition by sulfide and hydrogen peroxide-induced mutagenicity in Salmonella typhimurium strain TA102
- 1988
-
Ingår i: Mutation research. - : Elsevier. - 0027-5107 .- 1873-135X. ; 202:1, s. 59-64
-
Tidskriftsartikel (refereegranskat)abstract
- The lethal and mutagenic effects of hydrogen peroxide were studied in exponentially growing cultures of Salmonella typhimurium strain TA102. Exposure of the cultures to non-lethal levels of sodium sulfide significantly increased the lethality and mutagenicity of hydrogen peroxide. The catalase activity was decreased in cells exposed to sodium sulfide, but there were no changes in the cellular levels of superoxide dismutase, glutathione reductase, or NADPH-dependent alkyl hydroperoxide reductase. Hydrogen peroxide-induced mutagenesis and killing of S. typhimurium strain TA102 in the presence of sulfide may in part be explained by an inactivation of catalase by sulfide.
|
|
| 6. |
- Claesson, Andreas, et al.
(författare)
-
Delay and performance of cardiopulmonary resuscitation in surf lifeguards after simulated cardiac arrest due to drowning.
- 2011
-
Ingår i: American Journal of Emergency Medicine. - : W.B. Saunders Co.. - 0735-6757 .- 1532-8171. ; 29:9, s. 1044-1050
-
Tidskriftsartikel (refereegranskat)abstract
- Abstract PURPOSE: To describe time delay during surf rescue and compare the quality of cardiopulmonary resuscitation (CPR) before and after exertion in surf lifeguards. METHODS: A total of 40 surf lifeguards at the Tylösand Surf Lifesaving Club in Sweden (65% men; age, 19-43 years) performed single-rescuer CPR for 10 minutes on a Laerdal SkillmeteÔ Resusci Anne manikin. The test was repeated with an initial simulated surf rescue on an unconscious 80-kg victim 100 m from the shore. The time to victim, to first ventilation, and to the start of CPR was documented. RESULTS: The mean time in seconds to the start of ventilations in the water was 155 ± 31 (mean ± SD) and to the start of CPR, 258 ± 44. Men were significantly faster during rescue (mean difference, 43 seconds) than women (P = .002). The mean compression depth (millimeters) at rest decreased significantly from 0-2 minutes (42.6 ± 7.8) to 8-10 minutes (40.8 ± 9.3; P = .02). The mean compression depth after exertion decreased significantly (44.2 ± 8.7 at 0-2 minutes to 41.5 ± 9.1 at 8-10 minutes; P = .0008). The compression rate per minute decreased after rescue from 117.2 ±14.3 at 0 to 2 minutes to 114.1 ± 16.1 after 8 to 10 minutes (P = .002). The percentage of correct compressions at 8 to 10 minutes was identical before and after rescue (62%). CONCLUSION: In a simulated drowning, 100 m from shore, it took twice as long to bring the patient back to shore as to reach him; and men were significantly faster. Half the participants delivered continuous chest compressions of more than 38 mm during 10 minutes of single-rescuer CPR. The quality was identical before and after surf rescue. Copyright © 2011 Elsevier Inc. All rights reserved.
|
|
| 7. |
- Ericsson, Stina, et al.
(författare)
-
Att leka på lika villkor och ha roligt : Interaktion mellan barn med och utan funktionsnedsättning och LekBot
- 2013
-
Ingår i: Abstractsamling för OFTI 31 den 26-27 september 2013. - Uppsala. ; , s. 4-4
-
Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Det finns inte mycket tidigare forskning om barn med och utan funktionsnedsättning i lek med varandra, och den forskning som finns visar att barn med funktionsnedsättning intar en passiv roll. Roboten LekBot är utvecklad för att bland annat främja lek på lika villkor och rolig lek mellan barn med och utan funktionsnedsättning. Utifrån ett material bestående av totalt 18 videoinspelade interaktioner mellan barn med cerebral pares, deras lekkamrater, LekBot-systemet och vuxna medhjälpare, undersöker vi här jämlikhet mellan barnen och uttryck för rolighet i interaktioner med lekroboten. Analysen visar bland annat hur leken kan bli rolig till följd av funktionalitet i själva systemet och genom både barns och vuxnas kreativa användning av LekBot. Leken är dock långtifrån alltid rolig. Vad gäller jämlikhet syns ett komplext mönster med både passivitet och aktivitet hos barnen, med exempel på både jämlikhet och ojämlikhet, och med vuxnas arbete för att främja deltagande och jämlikhet.
|
|
| 8. |
- Eriksson, Britt-Marie, et al.
(författare)
-
A prospective study of rapid methods of detecting cytomegalovirus in the blood of renal transplant recipients in relation to patient and graft survival
- 1996
-
Ingår i: Clinical Transplantation. - 0902-0063 .- 1399-0012. ; 10:6 Pt 1, s. 494-502
-
Tidskriftsartikel (refereegranskat)abstract
- Eighty-five renal transplant recipients were prospectively monitored for CMV infection up to 4 months post-transplantation by virus isolation from leukocytes, CMV antigen detection (pp65) in peripheral blood leukocytes (PBL), polymerase chain reaction (PCR) of alkaline treated plasma (P-PCR), PCR of extracted DNA from PBL (L-PCR) and serology. Additionally univariate and multivariate analyses of risk factors for patient and graft survival up to 4 yr post-transplantation were performed. The incidence of CMV infection was 78% and of CMV disease 33%. Antigen detection in PBL was positive before or at onset of symptoms in 23/24 (96%) evaluable patients with CMV disease. The corresponding figures for virus isolation were 22/24 (92%), P-PCR 21/24 (88%) and for L-PCR 18/24 (75%). The percentage of negative samples in patients without CMV disease was 89% for the antigen test, 92% for L-PCR and 83% for virus isolation and P-PCR. One rapid test (antigen test, P-PCR or L-PCR) was positive at a median of 16 d before the onset of symptoms. The antigen test was generally the first rapid test to become positive. CMV disease did not affect graft survival in the multivariate analysis but was associated with decreased patient survival.
|
|
| 9. |
- Eriksson, Britt-Marie, et al.
(författare)
-
Circulating soluble vascular cell adhesion molecule-1 and intercellular adhesion molecule-1 in immunocompetent and renal transplant patients:correlation with cytomegalovirus disease and renal function
- 2001
-
Ingår i: Scandinavian Journal of Infectious Diseases. - : Informa UK Limited. - 0036-5548 .- 1651-1980. ; 33:5, s. 350-354
-
Tidskriftsartikel (refereegranskat)abstract
- The plasma levels of the soluble adhesion molecules, soluble vascular cell adhesion molecule-1 (sVCAM-1) and intercellular adhesion molecule-1 (sICAM-1), were measured before and after transplantation in 26 renal transplant recipients, and in 173 longitudinally collected samples in 17 of the patients. The patients were carefully monitored for the presence of cytomegalovirus (CMV) infection and rejection. Forty healthy blood donors and 12 otherwise healthy subjects with symptomatic primary CMV infections served as controls. During CMV disease, plasma levels of sVCAM-1 and sICAM-1 were elevated in both renal transplant patients and otherwise healthy subjects with CMV disease. The sVCAM-1 levels were strongly elevated before transplantation in renal transplant recipients and correlated with creatinine levels. Increased sVCAM-1 levels were also registered during rejection episodes. CMV disease, per se, is associated with markedly increased levels of sVCAM-1 and sICAM-1. There is also a correlation of sVCAM-1 levels with serum creatinine levels. Thus, the presence of CMV infection and renal function are factors that must be considered in further studies of soluble adhesion molecules.
|
|
| 10. |
- Ferm, Ulrika, 1966, et al.
(författare)
-
Participation and Enjoyment in Play with a Robot between Children with Cerebral Palsy who use AAC and their Peers
- 2015
-
Ingår i: Augmentative and Alternative Communication : AAC. - : Informa UK Limited. - 0743-4618 .- 1477-3848. ; 31:2, s. 108-123
-
Tidskriftsartikel (refereegranskat)abstract
- this study explores children with complex communication needs, their peers and adult support persons in play with the talking and moving robot lekBot. two triads were filmed playing with lekBot at pre-school. lekBot was developed to facilitate independent and enjoyable play on equal terms for children with significant communication disabilities and their peers. Using Conversation analysis, participatory symmetry and enjoyment were investigated in relation to spoken and gestural communication, embodied stance, gaze, and affective display. Data originated from three video-recorded sessions that were approximately 2 hours long. Four different interaction situations were identified and explored: Participatory asymmetry, adult Facilitation, Greater Participatory symmetry and Creativity, and turn-taking and enjoyable Play with lekBot. neither participatory symmetry nor enjoyment were easily achieved in the play sessions and may require considerable effort, including adult involvement, but creative, spontaneous and highly enjoyable play, correlating with participatory symmetry to various degrees, was observed in a few instances.the findings are discussed with regard to play, aaC and the future development of robots to facilitate play.
|
|
