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1.	Clausson, B, et al. (author) Effect of caffeine exposure during pregnancy on birth weight and gestational age 2002 In: American journal of epidemiology. - : Oxford University Press (OUP). - 0002-9262. ; 155, s. 429- Journal article (peer-reviewed)
2.	Clausson, B, et al. (author) Genetic influence on birthweight and gestational length determined by studies in offspring of twins 2000 In: BJOG : an international journal of obstetrics and gynaecology. - : Wiley. - 1470-0328 .- 1471-0528. ; 107, s. 375- Journal article (peer-reviewed)
3.	Clausson, B, et al. (author) Outcomes of post-term births: the role of fetal growth restriction and malformations 1999 In: Obstetrics and gynecology. - 0029-7844. ; 94, s. 758- Journal article (peer-reviewed)
4.	Clausson, B, et al. (author) Perinatal outcome in SGA births defined by customised versus population-based birthweight standards 2001 In: BJOG : an international journal of obstetrics and gynaecology. - : Wiley. - 1470-0328 .- 1471-0528. ; 108, s. 830- Journal article (peer-reviewed)
5.	Clausson, B, et al. (author) Preterm and term births of small for gestational age infants: a population-based study of risk factors among nulliparous women 1998 In: British journal of obstetrics and gynaecology. - : Wiley. - 0306-5456 .- 1470-0328 .- 1471-0528. ; 105, s. 1011- Journal article (peer-reviewed)
6.	Cnattingius, Sven, et al. (author) Caffein intake and the risk of first-trimester spontanous abortion 2000 In: N Engl J Med. ; 343, s. 1839- Journal article (peer-reviewed)
7.	Cnattingius, S, et al. (author) Caffeine intake and the risk of first-trimester spontaneous abortion 2000 In: The New England journal of medicine. - 0028-4793. ; 343:25, s. 1839-1845 Journal article (peer-reviewed)
8.	Tanner, L., et al. (author) Small-molecule-mediated OGG1 inhibition attenuates pulmonary inflammation and lung fibrosis in a murine lung fibrosis model 2023 In: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 14:1 Journal article (peer-reviewed)abstract Interstitial lung diseases such as idiopathic pulmonary fibrosis (IPF) are caused by persistent micro-injuries to alveolar epithelial tissues accompanied by aberrant repair processes. IPF is currently treated with pirfenidone and nintedanib, compounds which slow the rate of disease progression but fail to target underlying pathophysiological mechanisms. The DNA repair protein 8-oxoguanine DNA glycosylase-1 (OGG1) has significant roles in the modulation of inflammation and metabolic syndromes. Currently, no pharmaceutical solutions targeting OGG1 have been utilized in the treatment of IPF. In this study we show Ogg1-targeting siRNA mitigates bleomycin-induced pulmonary fibrosis in male mice, highlighting OGG1 as a tractable target in lung fibrosis. The small molecule OGG1 inhibitor, TH5487, decreases myofibroblast transition and associated pro-fibrotic gene expressions in fibroblast cells. In addition, TH5487 decreases levels of pro-inflammatory mediators, inflammatory cell infiltration, and lung remodeling in a murine model of bleomycin-induced pulmonary fibrosis conducted in male C57BL6/J mice. OGG1 and SMAD7 interact to induce fibroblast proliferation and differentiation and display roles in fibrotic murine and IPF patient lung tissue. Taken together, these data suggest that TH5487 is a potentially clinically relevant treatment for IPF but further study in human trials is required.

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Result 1-8 of 8

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Type of publication: journal article (8)

Type of content: peer-reviewed (8)

Author/Editor: Clausson, B (7); Cnattingius, S (6); Signorello, LB (3); Granath, F. (3); Ekbom, A (2); McLaughlin, JK (2); show more...; AXELSSON, O (2); Petersson, G (2); Blot, WJ (2); Wang, K. (1); Ekbom, Anders (1); Cnattingius, Sven (1); Lundgren, S (1); Lichtenstein, P. (1); Annerén, Göran (1); Anneren, G (1); Helleday, T (1); Andersson, C. K. (1); Erjefält, J. S. (1); Rane, A (1); Rane, Anders (1); Wallner, O (1); Kalderen, C. (1); Bergwik, J (1); Tanner, L (1); Egesten, A (1); Francis, A (1); Nordmark, A (1); Pan, L (1); Gardosi, J (1); Ljunger, Elisabeth (1); Ljunger, E (1); Malmström, J (1); Mohanty, T. (1); Single, A. B. (1); Bhongir, R. K.V. (1); Heusel, M. (1); Karlsson, C. A.Q. (1); Clausson, C. M. (1); Oommen, R. M. (1); Boldogh, I. (1); show less...

University: Karolinska Institutet (7); Uppsala University (6); Lund University (1)

Language: English (8)

Research subject (UKÄ/SCB): Medical and Health Sciences (1)

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