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- Xiao, L., et al.
(författare)
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A catalog of the mouse gut metagenome
- 2015
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Ingår i: Nature Biotechnology. - : Springer Science and Business Media LLC. - 1087-0156 .- 1546-1696. ; 33:10
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Tidskriftsartikel (refereegranskat)abstract
- We established a catalog of the mouse gut metagenome comprising similar to 2.6 million nonredundant genes by sequencing DNA from fecal samples of 184 mice. To secure high microbiome diversity, we used mouse strains of diverse genetic backgrounds, from different providers, kept in different housing laboratories and fed either a low-fat or high-fat diet. Similar to the human gut microbiome, >99% of the cataloged genes are bacterial. We identified 541 metagenomic species and defined a core set of 26 metagenomic species found in 95% of the mice. The mouse gut microbiome is functionally similar to its human counterpart, with 95.2% of its Kyoto Encyclopedia of Genes and Genomes (KEGG) orthologous groups in common. However, only 4.0% of the mouse gut microbial genes were shared (95% identity, 90% coverage) with those of the human gut microbiome. This catalog provides a useful reference for future studies.
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| 6. |
- Bäckhed, Fredrik, 1973, et al.
(författare)
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Dynamics and Stabilization of the Human Gut Microbiome during the First Year of Life
- 2015
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Ingår i: Cell Host & Microbe. - Cambridge : Elsevier BV. - 1931-3128 .- 1934-6069. ; 17:5, s. 690-703
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Tidskriftsartikel (refereegranskat)abstract
- The gut microbiota is central to human health, but its establishment in early life has not been quantitatively and functionally examined. Applying metagenomic analysis on fecal samples from a large cohort of Swedish infants and their mothers, we characterized the gut microbiome during the first year of life and assessed the impact of mode of delivery and feeding on its establishment. In contrast to vaginally delivered infants, the gut microbiota of infants delivered by C-section showed significantly less resemblance to their mothers. Nutrition had a major impact on early microbiota composition and function, with cessation of breast-feeding, rather than introduction of solid food, being required for maturation into an adult-like microbiota. Microbiota composition and ecological network had distinctive features at each sampled stage, in accordance with functional maturation of the microbiome. Our findings establish a framework for understanding the interplay between the gut microbiome and the human body in early life.
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| 9. |
- Elmqvist, T, et al.
(författare)
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Stadens ekosystem lever av andra ekosystem
- 2002
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Ingår i: Miljöforskning : Formas tidning för ett uthålligt samhälle. - 1650-4925. ; :1, s. 12-14
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 10. |
- Elmqvist, Tomas, et al.
(författare)
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Urban Systems
- 2008
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Ingår i: Encyclopedia of Ecology. - Oxford : Academic Press. ; , s. 3665-3672
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- Urbanization is a global multidimensional process which manifests itself through rapidly changing human population densities and changing land cover. Urbanization is viewed today as endangering more species and as more geographically ubiquitous than any other human activity and also the major driving force for increased homogenization of fauna and flora. The concept of ecosystem services has proven useful in describing human benefits from urban ecosystems. For example, urban vegetation may significantly reduce air pollution, mitigate the urban heat island effect, reduce noise, and enhance recreational and cultural values, of importance for urban citizen’s wellbeing. New opportunities lie in that urban landscapes are the very places where knowledge, innovation, and human and financial resources for getting solutions to global environmental problems are likely to be found.
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