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- Loughran, SJ, et al.
(författare)
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Mbd3/NuRD controls lymphoid cell fate and inhibits tumorigenesis by repressing a B cell transcriptional program
- 2017
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Ingår i: The Journal of experimental medicine. - : Rockefeller University Press. - 1540-9538 .- 0022-1007. ; 214:10, s. 3085-3104
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Tidskriftsartikel (refereegranskat)abstract
- Differentiation of lineage-committed cells from multipotent progenitors requires the establishment of accessible chromatin at lineage-specific transcriptional enhancers and promoters, which is mediated by pioneer transcription factors that recruit activating chromatin remodeling complexes. Here we show that the Mbd3/nucleosome remodeling and deacetylation (NuRD) chromatin remodeling complex opposes this transcriptional pioneering during B cell programming of multipotent lymphoid progenitors by restricting chromatin accessibility at B cell enhancers and promoters. Mbd3/NuRD-deficient lymphoid progenitors therefore prematurely activate a B cell transcriptional program and are biased toward overproduction of pro–B cells at the expense of T cell progenitors. The striking reduction in early thymic T cell progenitors results in compensatory hyperproliferation of immature thymocytes and development of T cell lymphoma. Our results reveal that Mbd3/NuRD can regulate multilineage differentiation by constraining the activation of dormant lineage-specific enhancers and promoters. In this way, Mbd3/NuRD protects the multipotency of lymphoid progenitors, preventing B cell–programming transcription factors from prematurely enacting lineage commitment. Mbd3/NuRD therefore controls the fate of lymphoid progenitors, ensuring appropriate production of lineage-committed progeny and suppressing tumor formation.
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- Schiavon, A., et al.
(författare)
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River Runs Dry : Movement Patterns of Telestes muticellus (Cypriniformes: Leuciscidae) in an Intermittent River Stretch
- 2024
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Ingår i: Advances in Hydraulic Research. - : Springer Science+Business Media B.V.. - 9783031560927 ; , s. 341-351
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- Intermittent flow is a natural phenomenon in many stream systems worldwide. At the same time, droughts are an increasing threat to ecosystems as a consequence of climate change and water diversion. Severe droughts can change once suitable habitats into ecological traps that cannot support fish communities. Although individual fish movements can allow populations affected by drought to persist, the knowledge about individual fish movement between intermittent and perennial stretches remains limited. Here we present Italian riffle dace (Telestes muticellus) movement patterns (n = 17) in an intermittent and a neighbouring perennial stream stretch before and after a severe summer drought. Fish initially resident in the intermittent section had similar summer survival as fish from the perennial section. The majority of fish from the intermittent river stretch survived the drought by upstream movements to perennially watered reaches (87.5%). Fish from the intermittent stretch showed an average upstream movement of about 100 m, whereas fish from the perennial stretch remained relatively stationary within the stream. Our result highlights the ability of Italian riffle dace to cope with drought by a directed migration to river reaches with the perennial flow. It also underscores the need to preserve longitudinal river connectivity in the face of increasing water scarcity and associated intermittent flows.
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