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- ter Veer, Emil, et al.
(författare)
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Consensus statement on mandatory measurements in pancreatic cancer trials (COMM-PACT) for systemic treatment of unresectable disease
- 2018
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Ingår i: The Lancet Oncology. - 1470-2045 .- 1474-5488. ; 19:3, s. E151-E160
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Forskningsöversikt (refereegranskat)abstract
- Variations in the reporting of potentially confounding variables in studies investigating systemic treatments for unresectable pancreatic cancer pose challenges in drawing accurate comparisons between findings. In this Review, we establish the first international consensus on mandatory baseline and prognostic characteristics in future trials for the treatment of unresectable pancreatic cancer. We did a systematic literature search to find phase 3 trials investigating first-line systemic treatment for locally advanced or metastatic pancreatic cancer to identify baseline characteristics and prognostic variables. We created a structured overview showing the reporting frequencies of baseline characteristics and the prognostic relevance of identified variables. We used a modified Delphi panel of two rounds involving an international panel of 23 leading medical oncologists in the field of pancreatic cancer to develop a consensus on the various variables identified. In total, 39 randomised controlled trials that had data on 15 863 patients were included, of which 32 baseline characteristics and 26 prognostic characteristics were identified. After two consensus rounds, 23 baseline characteristics and 12 prognostic characteristics were designated as mandatory for future pancreatic cancer trials. The COnsensus statement on Mandatory Measurements in unresectable PAncreatic Cancer Trials (COMM-PACT) identifies a mandatory set of baseline and prognostic characteristics to allow adequate comparison of outcomes between pancreatic cancer studies.
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| 2. |
- Sanchez-Cano, Beatriz, et al.
(författare)
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Origin of the Extended Mars Radar Blackout of September 2017
- 2019
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Ingår i: Journal of Geophysical Research - Space Physics. - : AMER GEOPHYSICAL UNION. - 2169-9380 .- 2169-9402. ; 124:6, s. 4556-4568
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Tidskriftsartikel (refereegranskat)abstract
- The Mars Advanced Radar for Subsurface and Ionosphere Sounding (MARSIS) onboard Mars Express, which operates between 0.1 and 5.5 MHz, suffered from a complete blackout for 10 days in September 2017 when observing on the nightside (a rare occurrence). Moreover, the Shallow Radar (SHARAD) onboard the Mars Reconnaissance Orbiter, which operates at 20 MHz, also suffered a blackout for three days when operating on both dayside and nightside. We propose that these blackouts are caused by solar energetic particles of few tens of keV and above associated with an extreme space weather event between 10 and 22 September 2017, as recorded by the Mars Atmosphere and Volatile EvolutioN (MAVEN) mission. Numerical simulations of energetic electron precipitation predict that a lower O-2(+) nighttime ionospheric layer of magnitude similar to 10(10) m(-3) peaking at similar to 90-km altitude is produced. Consequently, such a layer would absorb radar signals at high frequencies and explain the blackouts. The peak absorption level is found to be at 70-km altitude. Plain Language Summary Several instrument operations, as well as communication systems with rovers at the surface, depend on radio signals that propagate throughout the atmosphere of Mars. This is the case also for two radars that are currently working in Mars' orbit, sounding the ionosphere, surface, and subsurface of the planet. In mid-September 2017, a powerful solar storm hit Mars, producing a large amount of energetic particle precipitation over a 10-day period. We have found that high-energy electrons ionized the atmosphere of Mars, creating a dense layer of ions and electrons at similar to 90 km on the Martian nightside. This layer attenuated radar signals continuously for 10 days, stopping the radars to receive any signal from the planetary surface. In this work, we assess the properties of this layer in order to understand the implications of this kind of phenomenon for radar performance and communications.
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