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- Ongena, J., et al.
(författare)
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Recent progress on JET towards the ITER reference mode of operation at high density
- 2001
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Ingår i: Plasma Physics and Controlled Fusion. - 0741-3335 .- 1361-6587. ; 43, s. A11-A30
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Tidskriftsartikel (refereegranskat)abstract
- Recent progress towards obtaining high density and high confinement in JET as required for the ITER reference scenario at Q = 10 is summarized. Plasmas with simultaneous confinement H-98(y.2) = 1 and densities up to n/n(Gw) similar to 1 are now routinely obtained. This has been possible (i) by using plasmas at high (delta similar to 0.5) and medium (delta similar to 0.3-0.4) triangularity with sufficient heating power to maintain Type I ELMs, (ii) with impurity seeded plasmas at high (delta similar to 0.5) and low (delta less than or equal to 0.2) triangularity, (iii) with an optimized pellet injection sequence, maintaining the energy confinement and raising the density, and (iv) by carefully tuning the gas puff rate leading to plasmas with peaked density profiles and good confinement at long time scales. These high performance discharges exhibit Type I ELMs, with a new and more favourable behaviour observed at high densities, requiring further studies. Techniques for a possible mitigation of these ELMs are discussed, and first promising results are obtained with impurity seeding in discharges at high triangularity. Scaling studies using the new data of this year show a strong dependence of confinement on upper triangularity, density and proximity to the Greenwald limit. Observed MHD instabilities and methods to avoid these in high density and high confinement plasmas are discussed.
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| 9. |
- McDonald, C., et al.
(författare)
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ELMy H-modes in JET helium-4 plasmas
- 2004
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Ingår i: Plasma Physics and Controlled Fusion. - : IOP Publishing. - 0741-3335 .- 1361-6587. ; 46:3, s. 519-534
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Tidskriftsartikel (refereegranskat)abstract
- ELMy H-modes in helium-4 plasmas provide valuable information on ELMy H-mode physics as well as a possible early low activation operational phase for next-step tokamaks, such as ITER. With this in mind, a series of helium-4 H-mode experiments were performed on JET with pure helium-4 NBI auxiliary heating (up to 12 MW). A set of ELMy H-mode plasmas were produced, in both the Type I ELM regime and a second regime, which showed characteristics similar to the deuterium Type III regime, but with a reverse ELM frequency dependence on power. Sawteeth were also observed, and had similar behaviour to those seen in deuterium. Compared with deuterium plasmas, Type I ELMy H-mode confinement is seen to be 28 +/- 6% poorer in helium-4 plasmas and the L-H power threshold 42 +/- 10% larger. This is the opposite of the behaviour predicted by experimental isotope mass scalings from hydrogenic plasmas.Comparison with a wider hydrogenic database, enables the effects of isotopic charge and mass to be studied independently.
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| 10. |
- Hallqvist, Jenny, et al.
(författare)
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A Multiplexed Urinary Biomarker Panel Has Potential for Alzheimer's Disease Diagnosis Using Targeted Proteomics and Machine Learning
- 2023
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Ingår i: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. - 1661-6596 .- 1422-0067. ; 24:18
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Tidskriftsartikel (refereegranskat)abstract
- As disease-modifying therapies are now available for Alzheimer's disease (AD), accessible, accurate and affordable biomarkers to support diagnosis are urgently needed. We sought to develop a mass spectrometry-based urine test as a high-throughput screening tool for diagnosing AD. We collected urine from a discovery cohort (n = 11) of well-characterised individuals with AD (n = 6) and their asymptomatic, CSF biomarker-negative study partners (n = 5) and used untargeted proteomics for biomarker discovery. Protein biomarkers identified were taken forward to develop a high-throughput, multiplexed and targeted proteomic assay which was tested on an independent cohort (n = 21). The panel of proteins identified are known to be involved in AD pathogenesis. In comparing AD and controls, a panel of proteins including MIEN1, TNFB, VCAM1, REG1B and ABCA7 had a classification accuracy of 86%. These proteins have been previously implicated in AD pathogenesis. This suggests that urine-targeted mass spectrometry has potential utility as a diagnostic screening tool in AD.
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