| 1. |
- DAddio, Francesca, et al.
(författare)
-
The IGFBP3/TMEM219 pathway regulates beta cell homeostasis
- 2022
-
Ingår i: Nature Communications. - : Nature Portfolio. - 2041-1723. ; 13:1
-
Tidskriftsartikel (refereegranskat)abstract
- In this new study the Authors demonstrated that the IGFBP3/TMEM219 pathway is a physiological regulator of pancreatic beta cell homeostasis and it is dysregulated in diabetes. IGFBP3/TMEM219 targeting may therefore serve as a therapeutic option in diabetes. Loss of pancreatic beta cells is a central feature of type 1 (T1D) and type 2 (T2D) diabetes, but a therapeutic strategy to preserve beta cell mass remains to be established. Here we show that the death receptor TMEM219 is expressed on pancreatic beta cells and that signaling through its ligand insulin-like growth factor binding protein 3 (IGFBP3) leads to beta cell loss and dysfunction. Increased peripheral IGFBP3 was observed in established and at-risk T1D/T2D patients and was confirmed in T1D/T2D preclinical models, suggesting that dysfunctional IGFBP3/TMEM219 signaling is associated with abnormalities in beta cells homeostasis. In vitro and in vivo short-term IGFBP3/TMEM219 inhibition and TMEM219 genetic ablation preserved beta cells and prevented/delayed diabetes onset, while long-term IGFBP3/TMEM219 blockade allowed for beta cell expansion. Interestingly, in several patients cohorts restoration of appropriate IGFBP3 levels was associated with improved beta cell function. The IGFBP3/TMEM219 pathway is thus shown to be a physiological regulator of beta cell homeostasis and is also demonstrated to be disrupted in T1D/T2D. IGFBP3/TMEM219 targeting may therefore serve as a therapeutic option in diabetes.
|
|
| 2. |
- Edqvist, Erik, et al.
(författare)
-
A vibrating microcantilever sensor for microrobotic applications
-
Ingår i: Journal of Micromechanics and Microengineering. - 0960-1317 .- 1361-6439.
-
Tidskriftsartikel (refereegranskat)abstract
- In order to actively interact with the environment and to perform advanced tasks, microrobots need to be equipped with sensing tools to detect object and obstacles, and eventually manipulate and transport micro-parts. The concept, design, simulations and first characterization of a simple multifunctional microsystem, a vibrating microcantilever, capable of working as touch sensor and potentially as manipulation tool with feedback sensing is presented. The presented microcantilever was designed to be integrated onboard a microrobot of about 3 × 3 × 3 mm3. The microcantilever is applied as a sensing antenna on the microrobot in order to recognize objects or obstacles through direct contact, causing a voltage drop in a feedback layer. The microcantilever produced is 2.85×0.45×0.098 mm, and the experiments verified that it could be used as a contact sensor featuring high sensitivity with extremely low power consumption and good mass-manufacturability.
|
|
| 3. |
- Edqvist, Erik, et al.
(författare)
-
Evaluation of building technology for mass producible millimetre-sized robots using flexible printed circuit boards
- 2009
-
Ingår i: Journal of Micromechanics and Microengineering. - : Institute of Physics Publishing. - 0960-1317 .- 1361-6439. ; 19:7, s. 11pp-
-
Tidskriftsartikel (refereegranskat)abstract
- Initial tests of a building technology for a compact three-dimensional mass produciblemicrorobot are presented. The 3.9 × 3.9 × 3.3 mm3 sized prototype robot represents amicrosystem with actuators, sensors, energy management and integrated electronics. Theweight of a folded robot is 65 mg and the total volume is less than 23 mm3. The design of theinterfaces of the different modules in the robot, as well as the building technology, isdescribed. The modules are assembled using conductive adhesive with industrial surfacemounting technology on a thin double-sided flexible printed circuit board. The final shape ofthe microrobots is achieved by folding the flexible printed circuit board twice. Electrical andmechanical studies are performed to evaluate the assembly and it is concluded that thetechnology can be used for this type of microsystem. Several issues using the presentedassembly technique are identified and addressed.
|
|
